Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers
TL;DR: A review of the genetic landscape of HCC and iCCA discusses the most recent findings from genomic profiling and the current understanding of the pathways involved in the initiation and progression of liver cancer.
Journal ArticleDOI
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression
Roberto Rangel,Song Choon Lee,Kenneth Hon Kim Ban,Kenneth Hon Kim Ban,Liliana Guzman-Rojas,Michael B. Mann,Justin Y. Newberg,Takahiro Kodama,Leslie A. McNoe,Luxmanan Selvanesan,Jerrold M. Ward,Alistair G. Rust,Kuan Yew Chin,Michael A. Black,Nancy A. Jenkins,Nancy A. Jenkins,Neal G. Copeland,Neal G. Copeland +17 more
TL;DR: A transposon mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice provided a better understanding of the genetic forces driving TNBC and discovered genes with clinical importance in TNBC.
Journal ArticleDOI
Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment
Yue Cheng,Yee Peng Phoon,Xiwan Jin,Shing Yee Steffi Chong,Joseph Chok Yan Ip,Bonnie W.Y. Wong,Maria Li Lung +6 more
TL;DR: Novel findings confirm the ability of Wnt-C59 to suppress WNT-driven undifferentiated cell growth in NPC, and suggest both anti-Wnt signaling and anti-CSC approaches are feasible strategies in cancer therapy.
Journal ArticleDOI
MicroRNA-374b suppresses proliferation and promotes apoptosis in T-cell lymphoblastic lymphoma by repressing AKT1 and Wnt-16
Dong Qian,Dong Qian,Kailin Chen,Haixia Deng,Huilan Rao,Hui Qiang Huang,Yi-Ji Liao,Xiaofei Sun,Suying Lu,Zhiyong Yuan,Dan Xie,Qingqing Cai +11 more
TL;DR: Downregulation of miR-374b was frequently detected in primary T-LBL tissues, which was significantly associated with worse overall survival and increased risk of recurrence of the 58 patients enrolled in this study.
Journal ArticleDOI
Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9
Yonghao Li,Xiong Liu,Xian Lin,M Zhao,Yanyi Xiao,Chen Liu,Zixi Liang,Zelong Lin,Renhui Yi,Zibo Tang,Jiahao Liu,Xin Li,Qingping Jiang,Libo Li,Yinyin Xie,Zhen Liu,Zhen Liu,Weiyi Fang +17 more
TL;DR: Novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma (NPC) are presented.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.