Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Wnt3a neutralization enhances T-cell responses through indirect mechanisms and restrains tumor growth
Ilenia Pacella,Ilenia Cammarata,Chiara Focaccetti,Stefano Miacci,Alessandro Gulino,Claudio Tripodo,Micol Ravà,Vincenzo Barnaba,Vincenzo Barnaba,Silvia Piconese +9 more
TL;DR: It is suggested that Wnt3a neutralization might be a promising immunotherapy for rescuing dendritic cell activities in vivo and clarified the function of the Wnt 3a/β-catenin pathway in antitumor effector T cells.
Journal ArticleDOI
Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway.
TL;DR: It is found that polyphyllin I (PPI) inhibited the proliferation of myeloma cells and the mechanism of apoptosis induced by PPI was examined, suggesting that PPI is a novel inhibitor of β‐catenin activity with potential anti‐myeloma efficacy.
Journal ArticleDOI
Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators.
A. Serafino,P. Pierimarchi +1 more
TL;DR: This review summarizes the current knowledge on this topic, focusing on the recent data demonstrating that the antitumor activity of this natriuretic hormone is also mediated by a concomitant effect on the Wnt/β-catenin pathway and on the pH regulation ability of cancer cells, through a Frizzled-related mechanism.
Journal ArticleDOI
NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway.
TL;DR: NLRP3 could enhance resistance to gem citabine via IL-1β/EMT/Wnt/β-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC.
Journal ArticleDOI
Novel β-carbolines against colorectal cancer cell growth via inhibition of Wnt/β-catenin signaling.
Xing-Yao Li,B Bai,L Liu,Pengcheng Ma,Ling-Mei Kong,Jiangwei Yan,Jian Zhang,Zhen-Nan Ye,Hu Zhou,Bingyu Mao,Huifang Zhu,Yan Li +11 more
TL;DR: A novel promising chemotype for CRC therapeutics development targeting the canonical Wnt signaling is identified, isopropyl 9-ethyl- 1- (naphthalen-1-yl)-9H-pyrido[3,4-b]indole-3- carboxylate (Z86).
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.