Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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NCOA5 promotes proliferation, migration and invasion of colorectal cancer cells via activation of PI3K/AKT pathway.
TL;DR: It is demonstrated that expression of NCOA5 in human CRC tissues was notably higher than that in adjacent tissues, which significantly correlated with clinicopathological features such as length of tumor, regional lymph node staging and cancer staging.
Journal ArticleDOI
Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation *
Hye-Rim Shin,Rabia Islam,Won-Joon Yoon,Taegyung Lee,Young-Dan Cho,Han-Sol Bae,Bongsu Kim,Kyung Mi Woo,Jeong-Hwa Baek,Hyun-Mo Ryoo +9 more
TL;DR: It is found that Pin1 deficiency caused osteopenia and reduction of β-catenin in bone lining cells and could be a critical target to modulate β-Catenin-mediated osteogenesis.
Journal ArticleDOI
The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process.
TL;DR: The role of PEDF is summarized, focusing on endothelial dysfunction, inflammation, oxidative stress, angiogenesis and cell proliferation, and its promising therapeutic implications for atherosclerosis.
Journal ArticleDOI
Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless.
TL;DR: A presynaptic effector molecule of the Wingless/Wnt signal, Cortactin, is identified and it is shown that this molecule is a potent regulator of modifications in synaptic structure and is necessary for the electrophysiological changes taking place during synaptic plasticity.
Journal ArticleDOI
Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.
Robin T. Varghese,Sarah Young,Lily Pham,Yanping Liang,Kevin J. Pridham,Sujuan Guo,Susan Murphy,Deborah F. Kelly,Zhi Sheng +8 more
TL;DR: It is demonstrated that CK1ε regulates the survival of glioblastoma cells and gliOBlastoma stem cells through β-catenin signaling, underscoring the importance of targeting CK1 ε as an effective treatment for gli Oblastoma.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.