Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Expression Patterns of the Wnt Pathway Inhibitors Dickkopf3 and Secreted Frizzled-Related Proteins 1 and 4 in Endometrial Endometrioid Adenocarcinoma: An NRG Oncology/Gynecologic Oncology Group Study
Ramez N. Eskander,Shamshad Ali,Thanh H. Dellinger,Heather A. Lankes,Leslie M. Randall,Nilsa C. Ramirez,Bradley J. Monk,Joan L. Walker,Eric L. Eisenhauer,Bang H. Hoang +9 more
TL;DR: Wnt pathway inhibitor expression was down-regulated in patients with high-grade disease and was associated with locoregional and distant disease recurrence and may suggest a therapeutic role for Wnt signaling in endometrial cancer.
Journal ArticleDOI
The Role of Wnt and R-spondin in the Stomach During Health and Disease.
TL;DR: The connection between Wnt signaling and infection with Helicobacter pylori, a pathogen that colonizes the stomach and is the main risk factor for gastric cancer, is highlighted and experimental data that link WNT signaling to carcinogenesis are discussed.
Journal ArticleDOI
Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice.
Quan-Wen Liu,Jing-Yuan Li,Xiang-Cheng Zhang,Yu Liu,Qian-Yu Liu,Ling Xiao,Wen-Jie Zhang,Han-You Wu,Ke-Yu Deng,Hongbo Xin +9 more
TL;DR: It is reported that hAMSCs administrated by intravenous injection significantly inhibited HCC through suppressing cell proliferation and inducing cell apoptosis in tumour‐bearing mice with Hepg2 cells.
Journal ArticleDOI
Functional Crosstalk Between WNT Signaling and Tyrosine Kinase Signaling in Cancer.
TL;DR: The overall goals of this review are to describe mechanisms of crosstalk between WNT and tyrosine kinase pathways in cancer and to discuss how understanding intersections between W NT and tyrose kinase signaling networks might be exploited to improve current therapies.
Journal ArticleDOI
JQ-1 Inhibits Colon Cancer Proliferation via Suppressing Wnt/β-Catenin Signaling and miR-21.
TL;DR: It is revealed that the mechanism of JQ-1 action is associated with its regulation of Wnt/β-catenin signaling and miR-21 levels, which is effective in inhibiting colon cancer.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.