Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
Citations
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Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord
Carlos González-Fernández,Angel Arevalo-Martin,Beatriz Paniagua-Torija,Isidro Ferrer,Francisco Rodríguez,Daniel Garcia-Ovejero +5 more
TL;DR: A role for Wnts in the regulation of the adult spinal cord neurogenic niche is suggested and new data is provided on the specific differences in this region between humans and rodents.
Journal ArticleDOI
Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo
TL;DR: Notch2 silencing inhibited U87glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo and may be a key therapeutic target for the treatment of glioma.
Journal ArticleDOI
Hsa-miR-942 fingerprint in colorectal cancer through Wnt signaling pathway.
Ali Fasihi,Bahram M. Soltani,Zahra Sadat Ranjbaran,Sajedeh Bahonar,Romina Norouzi,Shirzad Nasiri +5 more
TL;DR: The findings established an oncogenic role for miR-942 in CRC and indicated that this miRNA might be a crucial target for CRC therapy.
Journal ArticleDOI
Wnt1 and SFRP1 as potential prognostic factors and therapeutic targets in cutaneous squamous cell carcinoma.
Halifu Y,Liang Jq,Zeng Xw,Ding Y,Xiyang Zhang,Tianbo Jin,Yakeya B,Abudu D,Zhou Ym,Xiaoming Liu,Hu Fx,Chai L,X.-J. Kang +12 more
TL;DR: It is concluded that Wnt1 and SFRP1 play important roles in the development of CSCC and could be potent markers for diagnosis, prevention, and therapy of CS CC.
Journal ArticleDOI
The physiological role of Wnt pathway in normal development and cancer.
TL;DR: The role of the Wnt pathway in normal development and tumorigenesis is highlighted, along with an overview of new therapies currently undergoing clinical trials and new strategies currently in clinical trials targeting Wnt signaling pathway components for cancer therapy are introduced.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.