Journal ArticleDOI
WNT signalling pathways as therapeutic targets in cancer
Jamie N. Anastas,Randall T. Moon +1 more
TLDR
This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.Abstract:
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.read more
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Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition
Aude Salomon,Michelle Keramidas,Michelle Keramidas,Michelle Keramidas,Cécile Maisin,Cécile Maisin,Cécile Maisin,Michaël Thomas,Michaël Thomas,Michaël Thomas +9 more
TL;DR: Findings indicate that β-catenin loss in H295R cells inhibits tumor growth by inducing transcriptional and functional changes.
Journal ArticleDOI
Alzheimer's disease: A protective factor for the ageing brain
Li-Huei Tsai,Ram Madabhushi +1 more
TL;DR: During ageing, a protein known as REST (repressor element 1-silencing transcription factor, also called NRSF) is increasingly expressed in human cortical and hippocampal neurons, and levels are strongly correlated with cognitive preservation and longevity.
Journal ArticleDOI
Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways
TL;DR: The findings suggest that targeting β-catenin gene may encourage the alterations of cell cycle and cell cycle regulators, and possibly takes part in the genesis and progression of colorectal cancer cells through regulating cell Cycle and the expression of cell Cycle regulators.
Journal ArticleDOI
Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy.
Paola M. Dantonio,Marianne O. Klein,Maria Renata V.B. Freire,Camila N. Araujo,Ana Carolina Chiacetti,Ricardo G. Correa +5 more
TL;DR: The importance of major signaling pathways (mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)-Akt, Wnt, nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB), Janus kinase-signal transducer and activator of transcription (STAT) in skin homeostasis and melanoma progression is summarized.
Journal ArticleDOI
Resveratrol restores sensitivity of glioma cells to temozolamide through inhibiting the activation of Wnt signaling pathway.
Hua-Chao Yang,Jun-Yi Wang,Xingyao Bu,Bin Yang,Bang-Qing Wang,Sen Hu,Zhaoyue Yan,Yushuai Gao,Shuang-Yin Han,Mingqi Qu +9 more
TL;DR: Resveratrol sensitized TMZ‐induced glioma cell apoptosis by repressing the activation of the Wnt signaling pathway and downregulating MGMT expression, which may confer new thoughts to the chemotherapy of gliomas.
References
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.