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David Melzer

Researcher at University of Exeter

Publications -  341
Citations -  37800

David Melzer is an academic researcher from University of Exeter. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 80, co-authored 328 publications receiving 33458 citations. Previous affiliations of David Melzer include Dalhousie University & Royal Devon and Exeter Hospital.

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
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A reference panel of 64,976 haplotypes for genotype imputation

Shane A. McCarthy, +117 more
- 22 Aug 2016 - 
TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josée Dupuis, +339 more
- 01 Feb 2010 - 
TL;DR: It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
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A genome-wide association search for type 2 diabetes genes in African Americans.

Nichole D. Palmer, +384 more
- 04 Jan 2012 - 
TL;DR: It is suggested that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
Journal Article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)

Josée Dupuis, +303 more
- 01 May 2010 -