K
Kee Seng Chia
Researcher at Hannover Medical School
Publications - 4
Citations - 1189
Kee Seng Chia is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Breast cancer & Genome-wide association study. The author has an hindex of 4, co-authored 4 publications receiving 1017 citations. Previous affiliations of Kee Seng Chia include University Health System & Hospital Authority.
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Journal ArticleDOI
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Kyriaki Michailidou,Jonathan Beesley,Sara Lindström,Sander Canisius,Joe Dennis,Michael Lush,Mel Maranian,Manjeet K. Bolla,Qin Wang,Mitul Shah,Barbara Perkins,Kamila Czene,Mikael Eriksson,Hatef Darabi,Judith S. Brand,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Henrik Flyger,Sune F. Nielsen,Nazneen Rahman,Clare Turnbull,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos-Santos-Silva,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Ursula Eilber,Sabine Behrens,Heli Nevanlinna,Taru A. Muranen,Taru A. Muranen,Kristiina Aittomäki,Kristiina Aittomäki,Carl Blomqvist,Carl Blomqvist,Sofia Khan,Sofia Khan,Kirsimari Aaltonen,Kirsimari Aaltonen,Habibul Ahsan,Muhammad G. Kibriya,Alice S. Whittemore,Esther M. John,Kathleen E. Malone,Marilie D. Gammon,Marilie D. Gammon,Regina M. Santella,Giske Ursin,Giske Ursin,Enes Makalic,Daniel F. Schmidt,Graham Casey,David J. Hunter,Susan M. Gapstur,Mia M. Gaudet,W. Ryan Diver,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Christine D. Berg,Stephen J. Chanock,Jonine D. Figueroa,Robert N. Hoover,Diether Lambrechts,Patrick Neven,Patrick Neven,Hans Wildiers,Erik Van Limbergen,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Emily Hallberg,Emily Hallberg,Celine M. Vachon,Quinten Waisfisz,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Jingmei Li,Jianjun Liu,Jianjun Liu,Keith Humphreys,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Keun-Young Yoo,Keun-Young Yoo,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Pascal Guénel,Thérèse Truong,Claire Mulot,Marie Sanchez,Barbara Burwinkel,Frederik Marme,Harald Surowy,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Anna González-Neira,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Xiao-Ou Shu,Xiao-Ou Shu,Wei Lu,Wei Lu,Wei Lu,Yu Tang Gao,Yu Tang Gao,Yu Tang Gao,Hui Cai,Hui Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Gord Glendon,Anna Marie Mulligan,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Nur Aishah Taib,Gie Hooi Tan,Maartje J. Hooning,Antoinette Hollestelle,John W. M. Martens,J. Margriet Collée,William Blot,Lisa B. Signorello,Qiuyin Cai,John L. Hopper,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Carmel Apicella,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Pei Ei Wu,Ming-Feng Hou,Vessela N. Kristensen,Silje Nord,Grethe I. Grenaker Alnæs,Graham G. Giles,Roger L. Milne,Catriona McLean,Catriona McLean,Federico Canzian,Federico Canzian,Dimitrios Trichopoulos,Petra P.H. Peeters,Eiliv Lund,Malin Sund,Kay-Tee Khaw,Marc J. Gunter,Domenico Palli,Lotte Maxild Mortensen,Laure Dossus,José María Huerta,José María Huerta,A. Meindl,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Sarah Stewart-Brown,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Pornthep Siriwanarangsan,Mikael Hartman,Hui Miao,Kee Seng Chia,Ching Wan Chan,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Lothar Haeberle,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Anthony J. Swerdlow,Louise A. Brinton,Montserrat Garcia-Closas,Wei Zheng,Sandra L. Halverson,Martha J. Shrubsole,Martha J. Shrubsole,Jirong Long,Jirong Long,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Katri Pylkäs,Arja Jukkola-Vuorinen,Arja Jukkola-Vuorinen,Mervi Grip,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Natalia Bogdanova,Natalia Bogdanova,Thilo Dörk,Thilo Dörk,Arto Mannermaa,Arto Mannermaa,Vesa Kataja,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Tomasz Huzarski,Suleeporn Sangrajrang,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Maria Kabisch,Diana Torres,Susan L. Neuhausen,Hoda Anton-Culver,Craig Luccarini,Caroline Baynes,S. Ahmed,Catherine S. Healey,Daniel C. Tessier,Daniel Vincent,Francois Bacot,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Jacques Simard,Paul D.P. Pharoah,Peter Kraft,Alison M. Dunning,Georgia Chenevix-Trench,Per Hall,Douglas F. Easton +283 more
TL;DR: 15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.
Journal ArticleDOI
Cancer survival in Africa, Asia, and Central America: a population-based study
Rengaswamy Sankaranarayanan,Rajaraman Swaminathan,Hermann Brenner,Kexin Chen,Kee Seng Chia,Jian Guo Chen,Stephen Ck Law,Yoon Ok Ahn,Yong-Bing Xiang,B B Yeole,Hai Rim Shin,Viswanathan Shanta,Ze Hong Woo,N. Martin,Yupa Sumitsawan,Hutcha Sriplung,Adolfo Ortiz Barboza,Sultan Eser,Bhagwan M. Nene,Krittika Suwanrungruang,Padmavathiamma Jayalekshmi,Rajesh Dikshit,Henry Wabinga,Divina B. Esteban,Adriano V. Laudico,Yasmin Bhurgri,Ebrima Bah,Nasser Al-Hamdan +27 more
TL;DR: Variations in survival correlated with early detection initiatives and level of development of health services, and emphasises the need for urgent investments in improving awareness, population-based cancer registration, early detection programmes, health-services infrastructure, and human resources.
Journal ArticleDOI
Female Breast Cancer Incidence Among Asian and Western Populations: More Similar Than Expected
Hyuna Sung,Philip S. Rosenberg,Wan Qing Chen,Mikael Hartman,Wei-Yen Lim,Kee Seng Chia,Oscar Mang,Chun-Ju Chiang,Daehee Kang,Roger K.C. Ngan,Lap Ah Tse,William F. Anderson,Xiaohong R. Yang +12 more
TL;DR: Similar longitudinal age-specific incidence rates along with converging IRRs indicate that the age effects for invasive breast cancer are more similar among Asian and Western populations than might be expected from a solely cross-sectional analysis.
Journal ArticleDOI
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Wei-Yu Lin,Nicola J. Camp,Maya Ghoussaini,Jonathan Beesley,Kyriaki Michailidou,John L. Hopper,Carmel Apicella,Melissa C. Southey,Jennifer Stone,Marjanka K. Schmidt,Annegien Broeks,Laura J. van't Veer,Emiel J. Th. Rutgers,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Julian Peto,Isabel dos-Santos-Silva,Olivia Fletcher,Nichola Johnson,Manjeet K. Bolla,Qin Wang,Joe Dennis,Elinor J. Sawyer,Timothy H.T. Cheng,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Frederik Marmé,Harald Surowy,Barbara Burwinkel,Pascal Guénel,Thérèse Truong,Florence Menegaux,Claire Mulot,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna González-Neira,Guillermo Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Hoda Anton-Culver,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alfons Meindl,Peter Lichtner,Rita K. Schmutzler,Bertram Müller-Myhsok,Hiltrud Brauch,Thomas Brüning,Yon-Dschun Ko,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Heli Nevanlinna,Kristiina Aittomäki,Carl Blomqvist,Sofia Khan,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Akiyo Horio,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Annika Lindblom,Sara Margolin,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,kConFab Investigators,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Patrick Neven,Els Wauters,Hans Wildiers,Diether Lambrechts,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Bernardo Bonanni,Fergus J. Couch,Xianshu Wang,Celine M. Vachon,Kristen S. Purrington,Graham G. Giles,Roger L. Milne,Catriona McLean,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Jacques Simard,Mark S. Goldberg,Martine Dumont,Soo Hwang Teo,Cheng Har Yip,Norhashimah Hassan,Eranga N. Vithana,Vessela N. Kristensen,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Saila Kauppila,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Sandrine Tchatchou,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Montserrat Garcia-Closas,Jonine D. Figueroa,Jolanta Lissowska,Louise A. Brinton,Kamila Czene,Hatef Darabi,Mikael Eriksson,Judith S. Brand,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Jingmei Li,Jianjun Liu,Keith Humphreys,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Simon S. Cross,Malcolm W.R. Reed,William Blot,Lisa B. Signorello,Qiuyin Cai,Paul D.P. Pharoah,Barbara Perkins,Mitul Shah,Fiona M. Blows,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Mikael Hartman,Hui Miao,Kee Seng Chia,Thomas C. Putti,Ute Hamann,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Drakoulis Yannoukakos,Chen-Yang Shen,Chia-Ni Hsiung,Pei-Ei Wu,Shian-ling Ding,Alan Ashworth,Michael Jones,Nick Orr,Anthony J. Swerdlow,Helen Tsimiklis,Enes Makalic,Daniel F. Schmidt,Quang M. Bui,Stephen J. Chanock,David J. Hunter,Rebecca Hein,Norbert Dahmen,Lars Beckmann,Kirsimari Aaltonen,Taru A. Muranen,Tuomas Heikkinen,Astrid Irwanto,Nazneen Rahman,Clare Turnbull,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Per Hall,Georgia Chenevix-Trench,Alison M. Dunning,Douglas F. Easton,Angela Cox +220 more
TL;DR: Analyses of gene expression associations in peripheral blood and normal breast tissue indicate that CASP8 might be the target gene, suggest a mechanism involving apoptosis, and investigate the SNPs retained in the final model investigated.