Institution
Cancer Epidemiology Unit
About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.
Topics: Population, Cancer, Breast cancer, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study
Papers published on a yearly basis
Papers
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TL;DR: Using the data base of chemicals tested by the NCI Bioassay Program, it is observed that there is a very high correlation of the maximum doses tested (max-d) for rats and mice on a milligram per kilogram body weight per day basis.
113 citations
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University of Kiel1, Max Delbrück Center for Molecular Medicine2, International Agency for Research on Cancer3, Emory University4, Aarhus University5, French Institute of Health and Medical Research6, German Cancer Research Center7, National and Kapodistrian University of Athens8, University of Naples Federico II9, Prevention Institute10, Utrecht University11, Imperial College London12, University Medical Center Utrecht13, Andalusian School of Public Health14, Basque Government15, Lund University16, University of Gothenburg17, Umeå University18, University of Cambridge19, Medical Research Council20, Cancer Epidemiology Unit21, University of Bonn22
TL;DR: This study supports the hypothesis that diabetes is a risk factor for BTC (particularly GBC) and HCC, and further research is required to establish whether diabetes treatment or duration is associated with these cancers.
112 citations
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TL;DR: A case-control study conducted in South Africa provides new estimates of the risk of specific cancers of the female reproductive system associated with use of injectable and oral contraceptives.
Abstract: The NHLS/MRC Cancer Epidemiology Research Group at the National Health Laboratory Service is currently funded by the South African Medical Research Council and the (South African) National Health Laboratory Service; previous funding was received from the University of the Witwatersrand, CANSA (Cancer Association of South Africa), and Cancer Research UK. The Cancer Epidemiology Research Unit at The Cancer Council NSW is funded in the main by The Cancer Council New South Wales. The Cancer Research UK Epidemiology Unit is supported by Cancer Research UK. EB and KC are supported by the Australian National Health and Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
111 citations
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Westlake University1, University of Cambridge2, Utrecht University3, Oslo University Hospital4, Imperial College London5, International Agency for Research on Cancer6, Institut Gustave Roussy7, Lund University8, German Cancer Research Center9, Prevention Institute10, Aarhus University11, Aalborg University12, Cancer Epidemiology Unit13, Umeå University14, Andalusian School of Public Health15, University of Turin16, University of Potsdam17
TL;DR: Findings indicate an inverse association between plasma vitamin C, carotenoids, and their composite biomarker score, and incident type 2 diabetes in different European countries, and suggest that diets rich in even modestly higher fruit and vegetable consumption could help to prevent development of type 1 diabetes.
Abstract: Objective To investigate the association of plasma vitamin C and carotenoids, as indicators of fruit and vegetable intake, with the risk of type 2 diabetes. Design Prospective case-cohort study. Setting Populations from eight European countries. Participants 9754 participants with incident type 2 diabetes, and a subcohort of 13 662 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort of 340 234 participants: EPIC-InterAct case-cohort study. Main outcome measure Incident type 2 diabetes. Results In a multivariable adjusted model, higher plasma vitamin C was associated with a lower risk of developing type 2 diabetes (hazard ratio per standard deviation 0.82, 95% confidence interval 0.76 to 0.89). A similar inverse association was shown for total carotenoids (hazard ratio per standard deviation 0.75, 0.68 to 0.82). A composite biomarker score (split into five equal groups), comprising vitamin C and individual carotenoids, was inversely associated with type 2 diabetes with hazard ratios 0.77, 0.66, 0.59, and 0.50 for groups 2-5 compared with group 1 (the lowest group). Self-reported median fruit and vegetable intake was 274 g/day, 396 g/day, and 508 g/day for participants in categories defined by groups 1, 3, and 5 of the composite biomarker score, respectively. One standard deviation difference in the composite biomarker score, equivalent to a 66 (95% confidence interval 61 to 71) g/day difference in total fruit and vegetable intake, was associated with a hazard ratio of 0.75 (0.67 to 0.83). This would be equivalent to an absolute risk reduction of 0.95 per 1000 person years of follow up if achieved across an entire population with the characteristics of the eight European countries included in this analysis. Conclusions These findings indicate an inverse association between plasma vitamin C, carotenoids, and their composite biomarker score, and incident type 2 diabetes in different European countries. These biomarkers are objective indicators of fruit and vegetable consumption, and suggest that diets rich in even modestly higher fruit and vegetable consumption could help to prevent development of type 2 diabetes.
111 citations
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TL;DR: The risk for developing SNC in the exposed workers was 21 to 100+ times greater than the risk for SNC for those who were not exposed in most of the studies as mentioned in this paper, and most occupational groups with an increased SNC risk include furniture, boot and show workers, and workers in U.S. countries heavily involved in both petroleum and chemical manufacturing.
Abstract: Cancer of the nose and paranasal sinuses (SNC) has been attributed to occupational exposure to nickel, chromium, radium, dichlordiethyl sulphide, isopropyl oil, and hydrocarbons. Occupational groups with an increased SNC risk include furniture, boot and show workers, and workers in U.S. countries heavily involved in both petroleum and chemical manufacturing; specific agents have not been identified with certainty. In most of the studies, the risk for developing SNC in the exposed workers was 21 to 100+ times greater than the risk for SNC in those who were not exposed. Undifferentiated and squamous histologies are associated with nickel refining; adenocarcinomas are found in woodworkers, boot and show manufacturers, and textile workers. Most occupations at risk for SNC were also at risk for cancer of other sites, particularly lung and skin cancer. Study of the epidemiology of SNC may identify unrecognized carcinogens and occupational groups at increased cancer risk.
110 citations
Authors
Showing all 669 results
Name | H-index | Papers | Citations |
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Richard Peto | 183 | 683 | 231434 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Silvia Franceschi | 155 | 1340 | 112504 |
Timothy J. Key | 146 | 808 | 90810 |
Hans-Olov Adami | 145 | 908 | 83473 |
Alicja Wolk | 135 | 778 | 66239 |
Paolo Vineis | 134 | 1088 | 86608 |
Lars Klareskog | 131 | 697 | 63281 |
Eva Negri | 129 | 1010 | 66735 |
John A. Baron | 128 | 609 | 61182 |
Jack Cuzick | 128 | 754 | 79979 |
Anders Ekbom | 116 | 613 | 51430 |
C. La Vecchia | 115 | 817 | 53460 |
Valerie Beral | 114 | 471 | 53729 |
Carlo La Vecchia | 112 | 1265 | 56282 |