Cancer Epidemiology Unit

About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.

Postmenopausal endometrial cancer risk and body size in early life and middle age: prospective cohort study

Abstract: Postmenopausal endometrial cancer risk and body size in early life and middle age: prospective cohort study

The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries.

Abstract: Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz. Data providers used a single variable list that covered all three outcomes. After validity and plausibility checks data was provided to the outcome-specific working groups. In total, we collected data on 115,596 patients diagnosed with cancer from 1940 to 2011, of whom 83,333 had survived 5 years or more. Due to the eligibility criteria and other requirements different numbers of survivors were eligible for the analysis of each of the outcomes. Thus, 1014 patients with at least one cardiac event were identified from a cohort of 39,152 5-year survivors; for second cancers 3995 survivors developed at least one second cancer from a cohort of 71,494 individuals, and from the late mortality cohort of 79,441 who had survived at least 5 years, 9247 died subsequently. Through the close cooperation of many European countries and the establishment of one central data collection and harmonising centre, the project succeeded in generating the largest cohort of children with cancer to date.

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Abstract: Background Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs We explored these associations in a large prospective study of UK women Methods and Results The Million Women Study recruited 13 million women through the National Health Service Breast Screening Programme in England and Scotland Three years after recruitment, women were sent a second questionnaire that enquired about depression and regular use of medications in the previous 4 weeks The present analysis included those who responded and did not have prior VTE, cancer, or recent surgery Follow‐up for VTE was through linkage to routinely collected National Health Service statistics Cox regression analyses yielded adjusted hazard ratios and 95% CIs A total of 734 092 women (mean age 599 years) were included in the analysis; 69% reported use of antidepressants, 27% reported use of other psychotropic drugs, and 18% reported being treated for depression or anxiety but not use of psychotropic drugs During follow‐up for an average of 73 years , 3922 women were hospitalized for and/or died from VTE Women who reported antidepressant use had a significantly higher risk of VTE than women who reported neither depression nor use of psychotropic drugs (hazard ratio, 139; 95% CI, 123–156) VTE risk was not significantly increased in women who reported being treated for depression or anxiety but no use of antidepressants or other psychotropic drugs (hazard ratio, 119; 95% CI, 095–149) Conclusions Use of antidepressants is common in UK women and is associated with an increased risk of VTE