Institution
Cancer Epidemiology Unit
About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.
Topics: Population, Cancer, Breast cancer, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study
Papers published on a yearly basis
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TL;DR: Support for patients facing challenging decisions, such as the choice between mastectomy and breast conservation surgery for breast cancer, and the attitudes of clinicians are studied.
Abstract: Background:There is interest in interventions that provide support for patients facing challenging decisions, such as the choice between mastectomy and breast conservation surgery for breast cancer. However, it is difficult to implement these interventions. One potential source of resistance is the attitudes of clinicians.
Objective: To examine specialist breast clinicians’ opinions about the provision of decision support interventions (DesIs) for patients.
Methods: As part of the development of a web-based DesI (BresDex), semi-structured interviews were conducted with specialist clinicians [breast surgeons, breast care nurses (BCNs) and oncologists] from four breast units in a UK region, and speciality national opinion leaders. Interviews were recorded, transcribed and analysed using the Framework approach.
Results: A majority of the 24 clinicians interviewed did not have a working knowledge of DesIs and were ambivalent or sceptical. Many expressed conflicting opinions: they noted the potential benefits, but at the same time expressed reservations about information overlap, overload and about content that they considered inappropriate. Many wanted access to DesIs to be always under clinical supervision. In particular, they were uncertain as regards how DeSIs could be tailored to individual patients’ needs and also accommodate clinical practice variation. BCNs were particularly concerned that DesIs might induce patient anxiety and replace their role.
Conclusions: The concept of providing interventions to support patients in decision-making tasks generated concern, defensiveness and scepticism. These attitudes will be a significant barrier. Implementation efforts will need to recognize and address these issues if these interventions are to become embedded in clinical practice.
45 citations
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International Agency for Research on Cancer1, Cancer Epidemiology Unit2, Emory University3, Aarhus University4, Université Paris-Saclay5, Institut Gustave Roussy6, German Cancer Research Center7, University of Milan8, University of Naples Federico II9, Prevention Institute10, Imperial College London11, Utrecht University12, University of Tromsø13, University of Murcia14, University of Granada15, Umeå University16, University of Ioannina17
TL;DR: A positive association of TC risk with IL‐10 and a negative association with adiponectin that is probably restricted to women are indicated, indicating that Inflammation may play a role in TC in combination with or independently of excess weight.
Abstract: Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwi ...
45 citations
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Utrecht University1, University Medical Center Utrecht2, Aalborg University3, Aarhus University4, University of Paris-Sud5, French Institute of Health and Medical Research6, Institut Gustave Roussy7, German Cancer Research Center8, National and Kapodistrian University of Athens9, Academy of Athens10, Harvard University11, Prevention Institute12, University of Turin13, University of Tromsø14, University of Granada15, University of Murcia16, Lund University17, Umeå University18, University of Cambridge19, Cancer Epidemiology Unit20, International Agency for Research on Cancer21, Imperial College London22
TL;DR: This study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow‐up of more than 10 years, but a lower risk of colon cancer is suggested with high consumption of fruit and vegetables.
Abstract: Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and a variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of 13 years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than 10 years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but appears unlikely.
45 citations
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Utrecht University1, Zanjan University of Medical Sciences2, China Medical University (Taiwan)3, University of Freiburg4, German Cancer Research Center5, National and Kapodistrian University of Athens6, Academy of Athens7, Harvard University8, Prevention Institute9, Andalusian School of Public Health10, Umeå University11, Lund University12, Imperial College London13, University Medical Center Utrecht14, University of Cambridge15, Cancer Epidemiology Unit16, International Agency for Research on Cancer17
TL;DR: The evidence that mtDNA copy number is related to risk of CLL and supports the importance of mitochondrial dysfunction as a possible mechanistic pathway in CLL ontogenesis is substantially strengthened.
45 citations
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TL;DR: Women who reported having working at night were substantially different from those who reporting never having worked at night and many of the differences would put "ever night workers" at increased risks of cancer, vascular disease, and many other common conditions.
Abstract: Objectives The aim of this study was to compare the characteristics of women who had and had not worked at night in terms of their risk factors for common disease, indicators of general health, social activities, employment, and sleep behavior.
Methods The Million Women Study is a large prospective cohort study of women’s health in the United Kingdom with 1.3 million women recruited during 1996–2001 (aged 50–64 years) through 66 National Health Service breast screening centers. We analyzed the data from a random sample of 41 652 participants who, in 2009–2010, reported their history of night work.
Results Of the participants, 1 in 8 women (13%) reported that they had ever worked at night and 1 in 50 (2%) reported working at night for ≥20 years. For 33 sociodemographic, behavioral, reproductive, and hormonal factors examined, 20 showed highly significant differences between “ever” and “never” night workers (P<0.0001); 12 showed significant trends by duration of night work (P<0.01). In particular, compared to women who had never worked at night, women who had worked at night were more likely to (i) be of lower socioeconomic status [the odds ratio (OR) for ever versus never night workers of being in the lowest third of socioeconomic status was 1.15, 99% confidence interval (95% CI) 1.06–1.25]; (ii) have ever used hormone replacement therapy (HRT) for the menopause (OR 1.43, 99% CI 1.33–1.55); (iii) be current smokers (OR 1.37, 99% CI 1.19–1.58); and (iv) be obese (OR 1.26, 99% CI 1.15–1.37). Compared to women who had never worked at night, women who had worked at night for ≥20 years were more likely to be (i) of lower socioeconomic status (OR 1.28, 99% CI 1.04–1.57); (ii) nulliparous (OR 1.47, 99% CI 1.12–1.91); (iii) current smokers (OR 1.63, 99% CI 1.18–2.25); and (iv) obese (OR 1.55, 99% CI 1.25–1.93). Former night workers were more likely than never night workers to report a range of sleep disturbances, including poor quality of sleep (OR 1.15, 99% CI 1.01–1.31) and having to take medication to sleep (OR 1.35, 99% CI 1.15–1.60).
Conclusions Women who reported having worked at night were substantially different from those who reporting never having worked at night and many of the differences would put “ever night workers” at increased risks of cancer, vascular disease, and many other common conditions.
45 citations
Authors
Showing all 669 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Peto | 183 | 683 | 231434 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Silvia Franceschi | 155 | 1340 | 112504 |
Timothy J. Key | 146 | 808 | 90810 |
Hans-Olov Adami | 145 | 908 | 83473 |
Alicja Wolk | 135 | 778 | 66239 |
Paolo Vineis | 134 | 1088 | 86608 |
Lars Klareskog | 131 | 697 | 63281 |
Eva Negri | 129 | 1010 | 66735 |
John A. Baron | 128 | 609 | 61182 |
Jack Cuzick | 128 | 754 | 79979 |
Anders Ekbom | 116 | 613 | 51430 |
C. La Vecchia | 115 | 817 | 53460 |
Valerie Beral | 114 | 471 | 53729 |
Carlo La Vecchia | 112 | 1265 | 56282 |