Donghua University

About: Donghua University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Fiber & Nanofiber. The organization has 21155 authors who have published 21841 publications receiving 393091 citations. The organization is also known as: Dōnghuá Dàxué & China Textile University.

RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T₁-weighted MR imaging of gliomas.

Abstract: We report a convenient approach to prepare ultrasmall Fe3O4 nanoparticles (NPs) functionalized with an arginylglycylaspartic acid (RGD) peptide for in vitro and in vivo magnetic resonance (MR) imaging of gliomas. In our work, stable sodium citrate-stabilized Fe3O4 NPs were prepared by a solvothermal route. Then, the carboxylated Fe3O4 NPs stabilized with sodium citrate were conjugated with polyethylene glycol (PEG)-linked RGD. The formed ultrasmall RGD-functionalized nanoprobe (Fe3O4-PEG-RGD) was fully characterized using different techniques. We show that these Fe3O4-PEG-RGD particles with a size of 2.7 nm are water-dispersible, stable, cytocompatible and hemocompatible in a given concentration range, and display targeting specificity to glioma cells overexpressing αvβ3 integrin in vitro. With the relatively high r1 relaxivity (r1 = 1.4 mM(-1) s(-1)), the Fe3O4-PEG-RGD particles can be used as an efficient nanoprobe for targeted T1-weighted positive MR imaging of glioma cells in vitro and the xenografted tumor model in vivo via an active RGD-mediated targeting pathway. The developed RGD-functionalized Fe3O4 NPs may hold great promise to be used as a nanoprobe for targeted T1-weighted MR imaging of different αvβ3 integrin-overexpressing cancer cells or biological systems.

Graphene/cotton composite fabrics as flexible electrode materials for electrochemical capacitors

Abstract: Graphene/cotton composite fabrics were successfully synthesized via a facile “dipping and drying” process followed by a NaBH4 reduction method. The flexible 3D conductive network constructed by graphene sheets greatly enhances the conductivity of cotton fabrics. The morphology, structure and conductivity of the graphene/cotton composite fabrics were detailed characterized using scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR) and a standard four-point probe method. Electrochemical measurements demonstrated that the graphene/cotton composite fabrics were used as flexible electrodes for electrochemical capacitors showing good capacitance, excellent mechanical flexibility, and good stability, which may lead to their future potential application in flexible and wearable electronic devices.