Indiana University

About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.

Contributions and challenges for network models in cognitive neuroscience

Abstract: The confluence of new approaches in recording patterns of brain connectivity and quantitative analytic tools from network science has opened new avenues toward understanding the organization and function of brain networks. Descriptive network models of brain structural and functional connectivity have made several important contributions; for example, in the mapping of putative network hubs and network communities. Building on the importance of anatomical and functional interactions, network models have provided insight into the basic structures and mechanisms that enable integrative neural processes. Network models have also been instrumental in understanding the role of structural brain networks in generating spatially and temporally organized brain activity. Despite these contributions, network models are subject to limitations in methodology and interpretation, and they face many challenges as brain connectivity data sets continue to increase in detail and complexity.

Inhabited Institutions: Social Interactions and Organizational Forms in Gouldner’s Patterns of Industrial Bureaucracy

Abstract: Organizational sociologists often treat institutions as macro cultural logics, representations, and schemata, with less consideration for how institutions are ”inhabited“ (Scully and Creed, 1997) by people doing things together. As such, this article uses a symbolic interactionist rereading of Gouldner’s classic study Patterns of Industrial Bureaucracy as a lever to expand the boundaries of institutionalism to encompass a richer understanding of action, interaction, and meaning. Fifty years after its publication, Gouldner’s study still speaks to us, though in ways we (and he) may not have anticipated five decades ago. The rich field observations in Patterns remind us that institutions such as bureaucracy are inhabited by people and their interactions, and the book provides an opportunity for intellectual renewal. Instead of treating contemporary institutionalism and symbolic interaction as antagonistic, we treat them as complementary components of an “inhabited institutions approach” that focuses on local and extra–local embeddedness, local and extra-local meaning, and a skeptical, inquiring attitude. This approach yields a doubly constructed view: On the one hand, institutions provide the raw materials and guidelines for social interactions (“construct interactions”), and on the other hand, the meanings of institutions are constructed and propelled forward by social interactions. Institutions are not inert categories of meaning; rather they are populated with people whose social interactions suffuse institutions with local force and significance.

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.

Abstract: Autosomal recessive polycystic kidney disease (ARPKD) is characterized by dilation of collecting ducts and by biliary dysgenesis and is an important cause of renal- and liver-related morbidity and mortality. Genetic analysis of a rat with recessive polycystic kidney disease revealed an orthologous relationship between the rat locus and the ARPKD region in humans; a candidate gene was identified. A mutation was characterized in the rat and screening the 66 coding exons of the human ortholog (PKHD1) in 14 probands with ARPKD revealed 6 truncating and 12 missense mutations; 8 of the affected individuals were compound heterozygotes. The PKHD1 transcript, approximately 16 kb long, is expressed in adult and fetal kidney, liver and pancreas and is predicted to encode a large novel protein, fibrocystin, with multiple copies of a domain shared with plexins and transcription factors. Fibrocystin may be a receptor protein that acts in collecting-duct and biliary differentiation.

Specialization and evolution of endogenous small RNA pathways.

Abstract: The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.