Institution
Indiana University
Education•Bloomington, Indiana, United States•
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.
Topics: Population, Poison control, Context (language use), Health care, Cancer
Papers published on a yearly basis
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TL;DR: In this paper, the authors reported a direct examination of chemical enhancement by using an integrated flow injection and ultrasensitive optical imaging/spectroscopy system, where colloidal silver nanoparticles are immobilized on a glass surface inside a microflow device and single-particle SERS signals are observed in real time while the immobilized particles are treated by chemical reagents in the flow cell.
Abstract: Recent research in several groups has identified a new class of metal colloidal nanoparticles that is able to enhance the efficiencies of surface-enhanced Raman scattering (SERS) by as much as 1014−1015 fold. This enormous enhancement allows single-molecule detection and spectroscopy at room temperature. Previous single-molecule and single-particle studies have yielded important insights into the mechanism of electromagnetic field enhancement, but little is known about the contributions of surface active sites and chemical enhancement. Here we report a direct examination of chemical enhancement by using an integrated flow injection and ultrasensitive optical imaging/spectroscopy system. A key feature is that colloidal silver nanoparticles are immobilized on a glass surface inside a microflow device and that single-particle SERS signals are observed in real time while the immobilized particles are treated by chemical reagents in the flow cell. In situ surface plasmon scattering studies of spatially isolate...
679 citations
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Columbia University1, Centre Hospitalier Universitaire de Toulouse2, University of Melbourne3, University of Western Ontario4, Karolinska Institutet5, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico6, University of Milan7, Eli Lilly and Company8, Indiana University9, Avid Radiopharmaceuticals10
TL;DR: Solanezumab at a dose of 400 mg administered every 4 weeks in patients with mild Alzheimer's disease did not significantly affect cognitive decline and the secondary outcomes were considered to be descriptive and are reported without significance testing.
Abstract: Background Alzheimer’s disease is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to increase the clearance from the brain of soluble Aβ, peptides that may lead to toxic effects in the synapses and precede the deposition of fibrillary amyloid. Methods We conducted a double-blind, placebo-controlled, phase 3 trial involving patients with mild dementia due to Alzheimer’s disease, defined as a Mini–Mental State Examination (MMSE) score of 20 to 26 (on a scale from 0 to 30, with higher scores indicating better cognition) and with amyloid deposition shown by means of florbetapir positron-emission tomography or Aβ1-42 measurements in cerebrospinal fluid. Patients were randomly assigned to receive solanezumab at a dose of 400 mg or placebo intravenously every 4 weeks for 76 weeks. The primary outcome was the change from baseline to week 80 in the score on the 14-item cognitive subscale of the Alzheimer’s Disease Assessmen...
679 citations
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TL;DR: Early passive motion appeared to be an effective technique to improve the results of flexor tendon repairs in this area, and there was one rupture in the digits managed by early mobilization.
Abstract: The performance of 50 consecutive digits in 37 patients was analyzed following flexor tendon repair in Zone II. Twenty-five digits were managed by 3 1/2 weeks of immobilization followed by a program of gradually increased motion; 25 other digits by intermittent passive motion initiated within the first 5 days with active flexion commenced at 4 1/2 weeks. Results were graded according to the percentage of return of motion at the proximal and distal interphalangeal joints. There were four ruptures in the immobilization group with no excellent results, 12% being rated good, 28% fair, and 11% poor. In the digits managed by early mobilization there were 36% excellent, 20% good, 16% fair, 24% poor; there was one rupture in this group. Early passive motion appeared to be an effective technique to improve the results of flexor tendon repairs in this area.
678 citations
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Yukawa Institute for Theoretical Physics1, KEK2, Nagoya University3, Brookhaven National Laboratory4, Université Paris-Saclay5, Washington University in St. Louis6, University of Connecticut7, University of Bern8, University of Southern Denmark9, Spanish National Research Council10, University of Rome Tor Vergata11, University of Wuppertal12, Forschungszentrum Jülich13, Osaka University14, San Francisco State University15, Indiana University16, Graduate University for Advanced Studies17, American Physical Society18, University of Edinburgh19, University of Southampton20, Aix-Marseille University21, National Chiao Tung University22, Roma Tre University23, Columbia University24, Autonomous University of Madrid25, University of Washington26, University of Mainz27
TL;DR: The determination of the light-quark masses, the form factor, and the decay constant ratio arising in the semileptonic $$K \rightarrow \pi $$K→π transition at zero momentum transfer are reported on.
Abstract: We review lattice results related to pion, kaon, D- and B-meson physics with the aim of making them easily accessible to the particle-physics community. More specifically, we report on the determination of the light-quark masses, the form factor [Formula: see text], arising in the semileptonic [Formula: see text] transition at zero momentum transfer, as well as the decay constant ratio [Formula: see text] and its consequences for the CKM matrix elements [Formula: see text] and [Formula: see text]. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of [Formula: see text] and [Formula: see text] Chiral Perturbation Theory. We review the determination of the [Formula: see text] parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. The latter quantities are an addition compared to the previous review. For the heavy-quark sector, we provide results for [Formula: see text] and [Formula: see text] (also new compared to the previous review), as well as those for D- and B-meson-decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. Finally, we review the status of lattice determinations of the strong coupling constant [Formula: see text].
678 citations
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TL;DR: In this article, the process e(+)e(-) -> pi(+)pi(-) J/psi at a center-of-mass energy of 4.260 GeV using a 525 pb(-1) data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider was studied.
Abstract: We study the process e(+)e(-) -> pi(+)pi(-) J/psi at a center-of-mass energy of 4.260 GeV using a 525 pb(-1) data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross section is measured to be (62.9 +/- 1.9 +/- 3.7) pb, consistent with the production of the Y(4260). We observe a structure at around 3.9 GeV/c(2) in the pi(+/-) J/psi mass spectrum, which we refer to as the Z(c)(3900). If interpreted as a new particle, it is unusual in that it carries an electric charge and couples to charmonium. A fit to the pi(+/-) J/psi invariant mass spectrum, neglecting interference, results in a mass of (3899.0 +/- 3.6 +/- 4.9) MeV/c(2) and a width of (46 +/- 10 +/- 20) MeV. Its production ratio is measured to be R = (sigma(e(+)e(-) -> pi(+/-) Z(c)(3900)(-/+) -> pi(+)pi(-) J/psi)/sigma(e(+)e(-) -> pi(+)pi(-) J/psi)) = (21.5 +/- 3.3 +/- 7.5)%. In all measurements the first errors are statistical and the second are systematic.
677 citations
Authors
Showing all 64884 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
Stuart H. Orkin | 186 | 715 | 112182 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
David R. Williams | 178 | 2034 | 138789 |
D. M. Strom | 176 | 3167 | 194314 |
Markus Antonietti | 176 | 1068 | 127235 |
Lei Jiang | 170 | 2244 | 135205 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Nahum Sonenberg | 167 | 647 | 104053 |
Carl W. Cotman | 165 | 809 | 105323 |
Yang Yang | 164 | 2704 | 144071 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Gavin Davies | 159 | 2036 | 149835 |
Tyler Jacks | 158 | 463 | 115172 |