Institution
Indiana University
Education•Bloomington, Indiana, United States•
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.
Topics: Population, Poison control, Context (language use), Health care, Cancer
Papers published on a yearly basis
Papers
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TL;DR: The relation among lower-extremity muscle strength, lower-Extremity lean tissue mass, and osteoarthritis of the knee in men and women 65 years of age and older is studied.
Abstract: Background: The quadriceps weakness commonly associated with osteoarthritis of the knee is widely believed to result from disuse atrophy secondary to pain in the involved joint. However, quadriceps...
924 citations
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TL;DR: It is shown that three additional F box proteins, called AFB1, 2, and 3, also regulate auxin response and collectively mediate auxin responses throughout plant development.
924 citations
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TL;DR: In this paper, the authors developed, present and evaluate a refined, statistical index of model performance, which is a reformulation of Willmott's index of agreement, which was developed in the 1980s.
Abstract: In this paper, we develop, present and evaluate a refined, statistical index of model performance. This ‘new’ measure (dr) is a reformulation of Willmott's index of agreement, which was developed in the 1980s. It (dr) is dimensionless, bounded by − 1.0 and 1.0 and, in general, more rationally related to model accuracy than are other existing indices. It also is quite flexible, making it applicable to a wide range of model-performance problems. The two main published versions of Willmott's index as well as four other comparable dimensionless indices—proposed by Nash and Sutcliffe in 1970, Watterson in 1996, Legates and McCabe in 1999 and Mielke and Berry in 2001—are compared with the new index. Of the six, Legates and McCabe's measure is most similar to dr. Repeated calculations of all six indices, from intensive random resamplings of predicted and observed spaces, are used to show the covariation and differences between the various indices, as well as their relative efficacies. Copyright © 2011 Royal Meteorological Society
924 citations
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Memorial Sloan Kettering Cancer Center1, Cleveland Clinic2, Harvard University3, University of Michigan4, Northwestern University5, Duke University6, Wayne State University7, Medical University of South Carolina8, Roswell Park Cancer Institute9, Indiana University10, Stanford University11, Fox Chase Cancer Center12, Bristol-Myers Squibb13, Johns Hopkins University14
TL;DR: Nivolumab demonstrated antitumor activity with a manageable safety profile across the three doses studied in mRCC, and no dose-response relationship was detected as measured by PFS.
Abstract: Purpose Nivolumab is a fully human immunoglobulin G4 programmed death–1 immune checkpoint inhibitor antibody that restores T-cell immune activity. This phase II trial assessed the antitumor activity, dose-response relationship, and safety of nivolumab in patients with metastatic renal cell carcinoma (mRCC). Patients and Methods Patients with clear-cell mRCC previously treated with agents targeting the vascular endothelial growth factor pathway were randomly assigned (blinded ratio of 1:1:1) to nivolumab 0.3, 2, or 10 mg/kg intravenously once every 3 weeks. The primary objective was to evaluate the dose-response relationship as measured by progression-free survival (PFS); secondary end points included objective response rate (ORR), overall survival (OS), and safety. Results A total of 168 patients were randomly assigned to the nivolumab 0.3- (n = 60), 2- (n = 54), and 10-mg/kg (n = 54) cohorts. One hundred eighteen patients (70%) had received more than one prior systemic regimen. Median PFS was 2.7, 4.0, a...
923 citations
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TL;DR: MGF was shown to be a ligand for c-kit by cross-linking 125I-labeled MGF to c-Kit-expressing cells with subsequent immunoprecipitation of the complex with antiserum specific for the C-terminus of c- Kit.
922 citations
Authors
Showing all 64884 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
Stuart H. Orkin | 186 | 715 | 112182 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
David R. Williams | 178 | 2034 | 138789 |
D. M. Strom | 176 | 3167 | 194314 |
Markus Antonietti | 176 | 1068 | 127235 |
Lei Jiang | 170 | 2244 | 135205 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Nahum Sonenberg | 167 | 647 | 104053 |
Carl W. Cotman | 165 | 809 | 105323 |
Yang Yang | 164 | 2704 | 144071 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Gavin Davies | 159 | 2036 | 149835 |
Tyler Jacks | 158 | 463 | 115172 |