Institution
Indiana University
Education•Bloomington, Indiana, United States•
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.
Topics: Population, Poison control, Context (language use), Health care, Cancer
Papers published on a yearly basis
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TL;DR: Combining data from numerous empirical and computational studies, network approaches strongly suggest that brain hubs play important roles in information integration underpinning numerous aspects of complex cognitive function.
1,760 citations
TL;DR: The findings suggest that acetylated LDL(+)ulex-lectin(+) cells, commonly referred to as EPCs, do not proliferate but release potent proangiogenic growth factors, which may allow for development of novel angiogenic therapies relying on secreted growth factors or on recruitment of endogenous monocytes/macrophages to sites of ischemia.
Abstract: Background— Endothelial progenitor cells (EPCs) have been isolated from peripheral blood and can enhance angiogenesis after infusion into host animals. It is not known whether the proangiogenic effects are a result of such events as endothelial differentiation and subsequent proliferation of EPCs or secondary to secretion of angiogenic growth factors. Methods and Results— Human EPCs were isolated as previously described, and their phenotypes were confirmed by uptake of acetylated LDL and binding of ulex-lectin. EPC proliferation and surface marker expression were analyzed by flow cytometry, and conditioned medium was assayed for growth factors. The majority of EPCs expressed monocyte/macrophage markers such as CD14 (95.7±0.3%), Mac-1 (57.6±13.5%), and CD11c (90.8±4.9%). A much lower percentage of cells expressed the specific endothelial marker VE-cadherin (5.2±0.7%) or stem/progenitor-cell markers AC133 (0.16±0.05%) and c-kit (1.3±0.7%). Compared with circulating monocytes, cultured EPCs showed upregulati...
1,756 citations
University of Freiburg1, United States Department of Energy2, Lawrence Berkeley National Laboratory3, Kanazawa University4, University of Washington5, University of Leeds6, Graduate University for Advanced Studies7, National Institute for Basic Biology, Japan8, Monash University, Clayton campus9, Hokkaido University10, National Institute of Genetics11, University of Tokyo12, National Institute of Informatics13, Southern Illinois University Carbondale14, Nagoya University15, University of Regina16, Donald Danforth Plant Science Center17, University of Georgia18, Indiana University19, Ghent University20, Michigan State University21, Kenyon College22, Max Planck Society23, University of Giessen24, University of Mainz25, Arizona State University26, University of Tennessee Health Science Center27, San Diego State University28, University of Virginia29, University of Minnesota30, Rothamsted Research31, University of California, Berkeley32
TL;DR: This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments; acquisition of genes for tolerating terrestrial stresses; and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response.
Abstract: We report the draft genome sequence of the model moss Physcomitrella patens and compare its features with those of flowering plants, from which it is separated by more than 400 million years, and unicellular aquatic algae. This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments (e.g., flagellar arms); acquisition of genes for tolerating terrestrial stresses (e.g., variation in temperature and water availability); and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response. The Physcomitrella genome provides a resource for phylogenetic inferences about gene function and for experimental analysis of plant processes through this plant's unique facility for reverse genetics.
1,749 citations
TL;DR: In this paper, the authors identify the general barriers typically faced by K-12 schools when integrating technology into the curriculum for instructional purposes, namely: resources, institution, subject culture, attitudes and beliefs, knowledge and skills, and assessment.
Abstract: Although research studies in education show that use of technol- ogy can help student learning, its use is generally affected by certain barriers In this paper, we first identify the general barriers typically faced by K-12 schools, both in the United States as well as other countries, when integrating technology into the curriculum for instructional purposes, namely: (a) resources, (b) institution, (c) subject culture, (d) attitudes and beliefs, (e) knowledge and skills, and (f) assessment We then describe the strategies to overcome such barriers: (a) having a shared vision and technology integration plan, (b) overcoming the scarcity of resources, (c) changing attitudes and beliefs, (d) conducting professional development, and (e) reconsidering assessments Finally, we identify several current knowledge gaps pertaining to the barriers and strategies of technology integration, and offer pertinent recommendations for future research
1,747 citations
TL;DR: In this paper, a reformulated definition of international entrepreneurship is proposed and a model is presented of how the speed of entrepreneurial internationalization is influenced by various forces, such as enabling forces of technology, motivating forces of competition, mediating perceptions of entrepreneurs, and moderating forces of knowledge and networks.
Abstract: This article provides a reformulated definition of international entrepreneurship. Consistent with the new definition, a model is presented of how the speed of entrepreneurial internationalization is influenced by various forces. The model begins with an entrepreneurial opportunity and depicts the enabling forces of technology, the motivating forces of competition, the mediating perceptions of entrepreneurs, and the moderating forces of knowledge and networks that collectively determine the speed of internationalization.
1,739 citations
Authors
Showing all 64884 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Frank B. Hu | 250 | 1675 | 253464 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Bruce M. Spiegelman | 179 | 434 | 158009 |
| David R. Williams | 178 | 2034 | 138789 |
| D. M. Strom | 176 | 3167 | 194314 |
| Markus Antonietti | 176 | 1068 | 127235 |
| Lei Jiang | 170 | 2244 | 135205 |
| Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Carl W. Cotman | 165 | 809 | 105323 |
| Yang Yang | 164 | 2704 | 144071 |
| Jaakko Kaprio | 163 | 1532 | 126320 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Gavin Davies | 159 | 2036 | 149835 |
| Tyler Jacks | 158 | 463 | 115172 |