Indiana University

About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.

Polycentric systems for coping with collective action and global environmental change

Abstract: The 20th anniversary issue of Global Environmental Change provides an important opportunity to address the core questions involved in addressing ‘‘global environmental’’ problems—especially those related to climate change. Climate change is a global collective-action problem since all of us face the likelihood of extremely adverse outcomes that could be reduced if many participants take expensive actions. Conventional collective-action theory predicts that these problems will not be solved unless an external authority determines appropriate actions to be taken, monitors behavior, and imposes sanctions. Debating about global efforts to solve climate-change problems, however, has yet not led to an effective global treaty. Fortunately, many activities can be undertaken by multiple units at diverse scales that cumulatively make a difference. I argue that instead of focusing only on global efforts (which are indeed a necessary part of the long-term solution), it is better to encourage polycentric efforts to reduce the risks associated with the emission of greenhouse gases. Polycentric approaches facilitate achieving benefits at multiple scales as well as experimentation and learning from experience with diverse policies.

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

Abstract: We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55–4.30; P = 2 × 10−16). We also show six risk loci associated with proximal gene expression or DNA methylation.

The limited capacity model of mediated message processing

Abstract: This paper presents an information-processing model that is directly applicable to the investigation of how mediated messages are processed. It applies the model to the case of television viewing to demonstrate its applicability. It provides a measure for each part of the model. It presents evidence that supports the model in the television-viewing situation. Finally, it demonstrates how the model may be used to further research and understanding in well-known theoretical traditions. This model is not meant to stand in opposition to any of these theories but, rather, should work well with them by providing hypothesized mechanisms that may underlie well-known effects. This model should prove useful both to researchers and, eventually, to message producers. To the extent that we can better understand how the content and structure of messages interact with a viewer's information-processing system to determine which parts and how much of a communication message is remembered, we will make great strides in understanding how people communicate.