Indiana University

About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Abstract: There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance

Abstract: Plants can recognize pathogens through the action of disease resistance (R) genes, which confer resistance to pathogens expressing unique corresponding avirulence (avr) genes. The molecular basis of this gene-for-gene specificity is unknown. The Arabidopsis thaliana RPM1 gene enables dual specificity to pathogens expressing either of two unrelated Pseudomonas syringae avr genes. Despite this function, RPM1 encodes a protein sharing molecular features with recently described single-specificity R genes. Surprisingly, RPM1 is lacking from naturally occurring, disease-susceptible Arabidopsis accessions.

Antecedents and Behavior-Problem Outcomes of Parental Monitoring and Psychological Control in Early Adolescence

Abstract: The early childhood antecedents and behavior-problem correlates of monitoring and psychological control were examined in this prospective, longitudinal, multi-informant study. Parenting data were collected during home visit interviews with 440 mothers and their 13-year-old children. Behavior problems (anxiety/depression and delinquent behavior) were assessed via mother, teacher, and/or adolescent reports at ages 8 through 10 years and again at ages 13 through 14. Home-interview data collected at age 5 years were used to measure antecedent parenting (harsh/reactive, positive/proactive), family background (e.g., socioeconomic status), and mother-rated child behavior problems. Consistent with expectation, monitoring was anteceded by a proactive parenting style and by advantageous family-ecological characteristics, and psychological control was anteceded by harsh parenting and by mothers' earlier reports of child externalizing problems. Consistent with prior research, monitoring was associated with fewer delinquent behavior problems. Links between psychological control and adjustment were more complex: High levels of psychological control were associated with more delinquent problems for girls and for teens who were low in preadolescent delinquent problems, and with more anxiety/depression for girls and for teens who were high in preadolescent anxiety/depression.

Application Overview for the Book: Grid Computing – Making the Global Infrastructure a Reality

Abstract: From the Publisher: Grid computing is applying the resources of many computers in a network to a single problem at the same time Grid computing appears to be a promising trend for three reasons: (1) Its ability to make more cost-effective use of a given amount of computer resources, (2) As a way to solve problems that can't be approached without an enormous amount of computing power (3) Because it suggests that the resources of many computers can be cooperatively and perhaps synergistically harnessed and managed as a collaboration toward a common objective. A number of corporations, professional groups, university consortiums, and other groups have developed or are developing frameworks and software for managing grid computing projects. The European Community (EU) is sponsoring a project for a grid for high-energy physics, earth observation, and biology applications. In the United States, the National Technology Grid is prototyping a computational grid for infrastructure and an access grid for people. Sun Microsystems offers Grid Engine software. Described as a distributed resource management tool, Grid Engine allows engineers at companies like Sony and Synopsys to pool the computer cycles on up to 80 workstations at a time. "the Grid" is a very hot topic generating broad interest from research and industry (e.g. IBM, Platform, Avaki, Entropia, Sun, HP) Grid architecture enables very popular e-Science projects like the Genome project which demand global interaction and networking In recent surveys over 500f Chief Information Officers are expected to use Grid technology this year Grid Computing: Features contributions from the major players in the field Covers all aspects of grid technology from motivation to applications Provides an extensive state-of-the-art guide in grid computing This is essential reading for researchers in Computing and Engineering, physicists, statisticians, engineers and mathematicians and IT policy makers.

Functional Ecdysone Receptor Is the Product of EcR and Ultraspiracle Genes

Abstract: Although the biological activity of the insect moulting hormone ecdysone, is manifested through a hormonally regulated transcriptional cascade associated with chromosomal puffing, a direct association of the receptor with the puff has yet to be established. The cloned ecdysone receptor (EcR) is by itself incapable of high-affinity DNA binding or transcriptional activation. Rather, these activities are dependent on heterodimer formation with Ultraspiracle (USP) the insect homologue of vertebrate retinoid X receptor. Here we report that native EcR and USP are co-localized on ecdysone-responsive loci of polytene chromosomes. Moreover, we show that natural ecdysones selectively promote physical association between EcR and USP, and conversely, that high-affinity hormone binding requires both EcR and USP. Replacement of USP with retinoid X receptor produces heterodimers with distinct pharmacological and functional properties. These results redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand.