Institution
International Centre for Diarrhoeal Disease Research, Bangladesh
Facility•Dhaka, Bangladesh•
About: International Centre for Diarrhoeal Disease Research, Bangladesh is a facility organization based out in Dhaka, Bangladesh. It is known for research contribution in the topics: Population & Vibrio cholerae. The organization has 3103 authors who have published 5238 publications receiving 226880 citations. The organization is also known as: SEATO Cholera Research Laboratory & Bangladesh International Centre for Diarrhoeal Disease Research.
Topics: Population, Vibrio cholerae, Cholera, Public health, Health care
Papers published on a yearly basis
Papers
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TL;DR: Peer counselling can effectively increase the initiation and duration of exclusive breastfeeding and recommend incorporation of peer counsellors in mother and child health programmes in developing countries.
411 citations
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TL;DR: There are many promising measures that might be pursued: establishment of goals for improved coverage in the poor, rather than in entire populations, and use of those goals to direct planning toward the needs of the disadvantaged.
407 citations
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TL;DR: The importance of separating biological or behavioural interventions from the delivery systems required to put them in place is highlighted, and the need to tailor delivery strategies to the stage of health-system development is discussed.
404 citations
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Johns Hopkins University1, University of North Carolina at Chapel Hill2, International Centre for Diarrhoeal Disease Research, Bangladesh3, University of Tampere4, Universidade Católica de Pelotas5, Southampton General Hospital6, Harvard University7, Emory University8, Pennington Biomedical Research Center9, Institute of Tropical Medicine Antwerp10, Ghent University11, King Edward Memorial Hospital12, Kenya Medical Research Institute13, Memorial Hospital of South Bend14, University College London15, Uppsala University16, University of the Witwatersrand17, Centers for Disease Control and Prevention18, Liverpool School of Tropical Medicine19, Universidade Federal de Pelotas20, Xi'an Jiaotong University21
TL;DR: It is estimated that childhood undernutrition may have its origins in the foetal period, suggesting a need to intervene early, ideally during pregnancy, with interventions known to reduce FGR and preterm birth.
Abstract: Background Low- and middle-income countries continue to experience a large burden of stunting; 148 million children were estimated to be stunted, around 30–40% of all children in 2011. In many of these countries, foetal growth restriction (FGR) is common, as is subsequent growth faltering in the first 2 years. Although there is agreement that stunting involves both prenatal and postnatal growth failure, the extent to which FGR contributes to stunting and other indicators of nutritional status is uncertain.
Methods Using extant longitudinal birth cohorts (n = 19) with data on birthweight, gestational age and child anthropometry (12–60 months), we estimated study-specific and pooled risk estimates of stunting, wasting and underweight by small-for-gestational age (SGA) and preterm birth.
Results We grouped children according to four combinations of SGA and gestational age: adequate size-for-gestational age (AGA) and preterm; SGA and term; SGA and preterm; and AGA and term (the reference group). Relative to AGA and term, the OR (95% confidence interval) for stunting associated with AGA and preterm, SGA and term, and SGA and preterm was 1.93 (1.71, 2.18), 2.43 (2.22, 2.66) and 4.51 (3.42, 5.93), respectively. A similar magnitude of risk was also observed for wasting and underweight. Low birthweight was associated with 2.5–3.5-fold higher odds of wasting, stunting and underweight. The population attributable risk for overall SGA for outcomes of childhood stunting and wasting was 20% and 30%, respectively.
Conclusions This analysis estimates that childhood undernutrition may have its origins in the foetal period, suggesting a need to intervene early, ideally during pregnancy, with interventions known to reduce FGR and preterm birth.
402 citations
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Pasteur Institute1, Leiden University Medical Center2, University of Tübingen3, International Centre for Diarrhoeal Disease Research, Bangladesh4, University of Ibadan5, Nangarhar University6, Mahidol University7, Papua New Guinea Institute of Medical Research8, University of Melbourne9, Walter and Eliza Hall Institute of Medical Research10, Mbarara University of Science and Technology11, Médecins Sans Frontières12, World Health Organization13, Jiangsu University14, National Institute of Parasitic Diseases15, Pennsylvania State University16, Cheikh Anta Diop University17, University of Lomé18, University of Douala19, Research Institute for Tropical Medicine20, Oswaldo Cruz Foundation21, University of Gondar22, Chinese Academy of Sciences23, Henry M. Jackson Foundation for the Advancement of Military Medicine24, Institut de recherche pour le développement25, University of Kinshasa26, University of Antwerp27, Thammasat University28, University of Bamako29, Medical University of Vienna30, Medicines for Malaria Venture31, Université Félix Houphouët-Boigny32, University of London33, Eijkman Institute for Molecular Biology34, Southwest University of Visual Arts35, Columbia University36, Paris Descartes University37
TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.
Abstract: BACKGROUND:
Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.
METHODS:
We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. We evaluated the emergence and dissemination of mutations by haplotyping neighboring loci.
RESULTS:
We identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution. In Asia, 36.5% of the K13 mutations were distributed within two areas--one in Cambodia, Vietnam, and Laos and the other in western Thailand, Myanmar, and China--with no overlap. In Africa, we observed a broad array of rare nonsynonymous mutations that were not associated with delayed parasite clearance. The gene-edited Dd2 transgenic line with the A578S mutation, which expresses the most frequently observed African allele, was found to be susceptible to artemisinin in vitro on a ring-stage survival assay.
CONCLUSIONS:
No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined. The common African A578S allele was not associated with clinical or in vitro resistance to artemisinin, and many African mutations appear to be neutral. (Funded by Institut Pasteur Paris and others.).
398 citations
Authors
Showing all 3121 results
Name | H-index | Papers | Citations |
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Stanley Falkow | 134 | 349 | 62461 |
Myron M. Levine | 123 | 789 | 60865 |
Roger I. Glass | 116 | 474 | 49151 |
Robert F. Breiman | 105 | 473 | 43927 |
Harry B. Greenberg | 100 | 433 | 34941 |
Barbara J. Stoll | 100 | 390 | 42107 |
Andrew M. Prentice | 99 | 550 | 46628 |
Robert H. Gilman | 96 | 903 | 43750 |
Robert E. Black | 92 | 201 | 56887 |
Johan Ärnlöv | 91 | 386 | 90490 |
Juan Jesus Carrero | 89 | 522 | 66970 |
John D. Clemens | 89 | 506 | 28981 |
William A. Petri | 85 | 507 | 26906 |
Toshifumi Hibi | 82 | 808 | 28674 |
David A. Sack | 80 | 437 | 23320 |