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Showing papers by "Paul Sabatier University published in 2007"


Journal ArticleDOI
TL;DR: It is shown here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells, indicating that PRDM 16 can control the determination of brown fat fate.

1,038 citations


Journal ArticleDOI
TL;DR: In this article, the authors proposed the Wind of Fast Rotating Massive Stars (WRSM) scenario to explain the origin of the abundance anomalies observed in globular clusters and discussed the nucleosynthesis in the H-burning core of these objects and present the chemical composition of their ejecta.
Abstract: Aims. We propose the Wind of Fast Rotating Massive Stars scenario to explain the origin of the abundance anomalies observed in globular clusters. Methods. We compute and present models of fast rotating stars with initial masses between 20 and 120 M ⊙ for an initial metallicity Z = 0.0005 ([Fe/H] ≃ -1.5). We discuss the nucleosynthesis in the H-burning core of these objects and present the chemical composition of their ejecta. We consider the impact of uncertainties in the relevant nuclear reaction rates. Results. Fast rotating stars reach critical velocity at the beginning of their evolution and remain near the critical limit during the rest of the main sequence and part of the He-burning phase. As a consequence they lose large amounts of material through a mechanical wind which probably leads to the formation of a slow outflowing disk. The material in this slow wind is enriched in H-buming products and presents abundance patterns similar to the chemical anomalies observed in globular cluster stars. In particular, the C, N, O, Na and Li variations are well reproduced by our model. However the rate of the 24 Mg(p, y) has to be increased by a factor 1000 around 50 x 10 6 K in order to reproduce the amplitude of the observed Mg-Al anticorrelation. We discuss how the long-lived low-mass stars currently observed in globular clusters could have formed out of the slow wind material ejected by massive stars.

787 citations


Journal ArticleDOI
TL;DR: The role of cathelicidin in skin inflammatory responses is confirmed and an explanation for the pathogenesis of rosacea is suggested by demonstrating that an exacerbated innate immune response can reproduce elements of this disease.
Abstract: Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and telangiectasia. The etiology of this disorder is unknown, although symptoms are exacerbated by factors that trigger innate immune responses, such as the release of cathelicidin antimicrobial peptides. Here we show that individuals with rosacea express abnormally high levels of cathelicidin in their facial skin and that the proteolytically processed forms of cathelicidin peptides found in rosacea are different from those present in normal individuals. These cathelicidin peptides are a result of a post-translational processing abnormality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis. In mice, injection of the cathelicidin peptides found in rosacea, addition of SCTE, and increasing protease activity by targeted deletion of the serine protease inhibitor gene Spink5 each increases inflammation in mouse skin. The role of cathelicidin in enabling SCTE-mediated inflammation is verified in mice with a targeted deletion of Camp, the gene encoding cathelicidin. These findings confirm the role of cathelicidin in skin inflammatory responses and suggest an explanation for the pathogenesis of rosacea by demonstrating that an exacerbated innate immune response can reproduce elements of this disease.

707 citations


Journal ArticleDOI
TL;DR: In this paper, the authors present a detailed literature review of fluvial geomorphology, riparian plant ecology and hydraulic engineering knowledge, and propose a "fluvial biogeomorphic succession" concept.

617 citations


Journal ArticleDOI
TL;DR: In this article, a coin cell assembled with microporous activated carbon and N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI) ionic liquid as the electrolyte was cycled for 40,000 cycles without any change of cell resistance.

574 citations


Journal ArticleDOI
TL;DR: The underlying mechanisms of complex collective behaviors of social insects, from the concept of stigmergy to the theory of self-organization in biological systems, are described and four functions that emerge at the level of the colony and that organize its global behavior are proposed.
Abstract: The roots of swarm intelligence are deeply embedded in the biological study of self-organized behaviors in social insects. From the routing of traffic in telecommunication networks to the design of control algorithms for groups of autonomous robots, the collective behaviors of these animals have inspired many of the foundational works in this emerging research field. For the first issue of this journal dedicated to swarm intelligence, we review the main biological principles that underlie the organization of insects’ colonies. We begin with some reminders about the decentralized nature of such systems and we describe the underlying mechanisms of complex collective behaviors of social insects, from the concept of stigmergy to the theory of self-organization in biological systems. We emphasize in particular the role of interactions and the importance of bifurcations that appear in the collective output of the colony when some of the system’s parameters change. We then propose to categorize the collective behaviors displayed by insect colonies according to four functions that emerge at the level of the colony and that organize its global behavior. Finally, we address the role of modulations of individual behaviors by disturbances (either environmental or internal to the colony) in the overall flexibility of insect colonies. We conclude that future studies about self-organized biological behaviors should investigate such modulations to better understand how insect colonies adapt to uncertain worlds.

502 citations


Journal ArticleDOI
TL;DR: In this paper, the authors study the homotopy theory of dg-categories up to quasi-equivalences. But their main purpose is to provide a natural description of the mapping spaces between two dgcategories $C$ and $D$ in terms of the nerve of a certain category of $(C,D)$-bimodules.
Abstract: The main purpose of this work is the study of the homotopy theory of dg-categories up to quasi-equivalences. Our main result provides a natural description of the mapping spaces between two dg-categories $C$ and $D$ in terms of the nerve of a certain category of $(C,D)$-bimodules. We also prove that the homotopy category $Ho(dg-Cat)$ is cartesian closed (i.e. possesses internal Hom's relative to the tensor product). We use these two results in order to prove a derived version of Morita theory, describing the morphisms between dg-categories of modules over two dg-categories $C$ and $D$ as the dg-category of $(C,D)$-bi-modules. Finally, we give three applications of our results. The first one expresses Hochschild cohomology as endomorphisms of the identity functor, as well as higher homotopy groups of the \emph{classifying space of dg-categories} (i.e. the nerve of the category of dg-categories and quasi-equivalences between them). The second application is the existence of a good theory of localization for dg-categories, defined in terms of a natural universal property. Our last application states that the dg-category of (continuous) morphisms between the dg-categories of quasi-coherent (resp. perfect) complexes on two schemes (resp. smooth and proper schemes) is quasi-equivalent to the dg-category of quasi-coherent complexes (resp. perfect) on their product.

500 citations



Journal ArticleDOI
TL;DR: In this paper, an activated carbon-MnO2 hybrid electrochemical supercapacitor was constructed and characterized in K2SO4 aqueous media, and a laboratory cell achieved 195,000 cycles with stable performance.

457 citations


Journal ArticleDOI
TL;DR: This article characterize the exact number of candidates for which manipulation becomes hard for the plurality, Borda, STV, Copeland, maximin, veto, plurality with runoff, regular cup, and randomized cup protocols and shows that for simpler manipulation problems, manipulation cannot be hard with few candidates.
Abstract: In multiagent settings where the agents have different preferences, preference aggregation is a central issue. Voting is a general method for preference aggregation, but seminal results have shown that all general voting protocols are manipulable. One could try to avoid manipulation by using protocols where determining a beneficial manipulation is hard. Especially among computational agents, it is reasonable to measure this hardness by computational complexity. Some earlier work has been done in this area, but it was assumed that the number of voters and candidates is unbounded. Such hardness results lose relevance when the number of candidates is small, because manipulation algorithms that are exponential only in the number of candidates (and only slightly so) might be available. We give such an algorithm for an individual agent to manipulate the Single Transferable Vote (STV) protocol, which has been shown hard to manipulate in the above sense. This motivates the core of this article, which derives hardness results for realistic elections where the number of candidates is a small constant (but the number of voters can be large).The main manipulation question we study is that of coalitional manipulation by weighted voters. (We show that for simpler manipulation problems, manipulation cannot be hard with few candidates.) We study both constructive manipulation (making a given candidate win) and destructive manipulation (making a given candidate not win). We characterize the exact number of candidates for which manipulation becomes hard for the plurality, Borda, STV, Copeland, maximin, veto, plurality with runoff, regular cup, and randomized cup protocols. We also show that hardness of manipulation in this setting implies hardness of manipulation by an individual in unweighted settings when there is uncertainty about the others' votes (but not vice-versa). To our knowledge, these are the first results on the hardness of manipulation when there is uncertainty about the others' votes.

411 citations


Journal ArticleDOI
TL;DR: In this paper, it was shown that thermohaline mixing is a fundamental physical process that must be included in stellar evolution modeling, and that it significantly reduces the 3 He production with respect to canonical evolution models as required by measurements of 3 He in galactic HII regions.
Abstract: Aims. Numerous spectroscopic observations provide compelling evidence for a non-canonical mixing process that modifies the surface abundances of Li, C and N of low-mass red giants when they reach the bump in the luminosity function. Eggleton and collaborators have proposed that a molecular weight inversion created by the 3 He( 3 He, 2p) 4 He reaction may be at the origin of this mixing, and relate it to the Rayleigh-Taylor instability. We argue that one is actually dealing with a double diffusive instability referred to as thermohaline convection and we discuss its influence on the red giant branch. Methods. We compute stellar models of various initial metallicities that include thermohaline mixing, which is treated as a diffusive process based on the prescription given originally by Ulrich for the turbulent diffusivity produced by the thermohaline instability in stellar radiation zones. Results. Thermohaline mixing simultaneously accounts for the observed behaviour of the carbon isotopic ratio and of the abundances of Li, C and N in the upper part of the red giant branch. It significantly reduces the 3 He production with respect to canonical evolution models as required by measurements of 3 He/H in galactic HII regions. Conclusions. Thermohaline mixing is a fundamental physical process that must be included in stellar evolution modeling.

Journal ArticleDOI
TL;DR: Comparison of metabolite levels in the culture supernatant and the cell interior revealed that the common assumption of whole broth quenching protocols attributing the metabolites found exclusively to the intracellular pools may not be valid in many cases.
Abstract: In the present work we investigated the most commonly applied methods used for sampling of microorganisms in the field of metabolomics in order to unravel potential sources of error previously ignored but of utmost importance for accurate metabolome analysis. To broaden the significance of our study, we investigated different Gram-negative and Gram-positive bacteria, i.e., Bacillus subtilis, Corynebacterium glutamicum, Escherichia coli, Gluconobacter oxydans, Pseudomonas putida, and Zymononas mobilis, and analyzed metabolites from different catabolic and anabolic intracellular pathways. Quenching of cells with cold methanol prior to cell separation and extraction led to drastic loss (>60%) of all metabolites tested due to unspecific leakage. Using fast filtration, Gram-negative bacteria also revealed a significant loss (>80%) when inappropriate washing solutions with low ionic strength were applied. Adapting the ionic strength of the washing solution to that of the cultivation medium could almost completely avoid this problem. Gram-positive strains did not show significant leakage independent of the washing solution. Fast filtration with sampling times of several seconds prior to extraction appears to be a suitable approach for metabolites with relatively high intracellular level and low turnover such as amino acids or TCA cycle intermediates. Comparison of metabolite levels in the culture supernatant and the cell interior revealed that the common assumption of whole broth quenching protocols attributing the metabolites found exclusively to the intracellular pools may not be valid in many cases. In such cases a differential approach correcting for medium-contained metabolites is required.

Journal ArticleDOI
TL;DR: In this paper, LiM alloys undergo large volume expansion and contraction during the charge-discharge cycling, which induces mechanical disintegration that results in very poor cycle life, and they are considered to be very appealing negative electrodes that may be exploited for the replacement of conventional graphite.
Abstract: Lithium metal (LiM) alloys, owing to their intrinsic high specific capacity, are considered to be very appealing negative electrodes that may be exploited for the replacement of conventional graphite in advanced design, lithium-ion batteries. LiM alloys, however, undergo large volume expansion and contraction during the charge–discharge cycling, which induces mechanical disintegration that results in very poor cycle life.

Journal ArticleDOI
TL;DR: In this article, the authors used time series of SAR images to map the flood temporal dynamics and the spatial distribution of vegetation over a large Amazonian floodplain using decision rules over two decision variables: 1) the mean backscatter coefficient computed over the whole time series; 2) the total change computed using an “Absolute Change” estimator.

Journal ArticleDOI
TL;DR: In this paper, a parametric strong lensing mass reconstruction using 34 multiply imaged systems of which 24 have newly determined spectroscopic redshifts is presented, which is a major step forward in building a robust mass model.
Abstract: We present a reconstruction of the mass distribution of galaxy cluster Abell 1689 at z=0.18 using detected strong lensing features from deep ACS observations and extensive ground based spectroscopy. Earlier analyses have reported up to 32 multiply imaged systems in this cluster, of which only 3 were spectroscopically confirmed. In this work, we present a parametric strong lensing mass reconstruction using 34 multiply imaged systems of which 24 have newly determined spectroscopic redshifts, which is a major step forward in building a robust mass model. In turn, the new spectroscopic data allows a more secure identification of multiply imaged systems. The resultant mass model enables us to reliably predict the redshifts of additional multiply imaged systems for which no spectra are currently available, and to use the location of these systems to further constrain the mass model. Using our strong lensing mass model, we predict on larger scale a shear signal which is consistent with that inferred from our large scale weak lensing analysis derived using CFH12K wide field images. Thanks to a new method for reliably selecting a well defined background lensed galaxy population, we resolve the discrepancy found between the NFW concentration parameters derived from earlier strong and weak lensing analysis. The derived parameters for the best fit NFW profile is found to be c200=7.6+/-1.6 and r200=2.16+/-0.10 h-170 Mpc (corresponding to a 3D mass equal to M200=[1.32+/-0.2]×1015 h70 Msolar). The large number of new constraints incorporated in this work makes Abell 1689 the most reliably reconstructed cluster to date. This well calibrated mass model, which we here make publicly available, will enable us to exploit Abell 1689 efficiently as a gravitational telescope, as well as to potentially constrain cosmology. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Also based on observations from the NASA/ESA Hubble Space Telescope (programs 9289 and 10150) obtained at the Space Telescope Science Institute, which is operated by AURA under NASA contract NAS5-26555.

Journal ArticleDOI
TL;DR: It is suggested that at least some toxins should actually be considered as allelopathic compounds, with emphasis on the ecological effects of the compounds in the immediate environment of the emitter algae.
Abstract: Summary 1. The photoautotrophic micro-organisms collectively termed ‘micro-algae’ (including micro-eukaryotes and cyanobacteria) are known to produce a wide range of secondary metabolites with various biological actions. A small subset of these compounds has been identified. Some of them, termed allelopathic compounds, have been shown to play a role in allelopathy, defined here as inhibitory effects of secondary metabolites against either competitors or predators. Freshwater cyanobacteria also produce some secondary metabolites, termed toxins, which are highly toxic for animals. 2. While allelopathic compounds play a role in the interactions between the emitter organisms and their direct competitors or predators, toxins are categorised according to their toxic effect on several organisms, including some that may not be present in their immediate environment. However, these two definitions are not mutually exclusive. This review considers the evolutionary, ecological and physiological aspects of the production of allelopathic compounds by micro-algae in freshwaters, and compares the characteristics of allelopathic compounds with those of toxins. 3. Allelopathic compounds include alkaloids, cyclic peptides, terpens and volatile organic compounds. Toxins include alkaloids, cyclic peptides and lipopolysaccharides. No allelopathic compound type is associated with a particular phylogenetic group of algae. In contrast, freshwater toxins are only produced by cyanobacteria belonging to a restricted number of genera. Allelopathic compounds have various modes of action, from inhibition of photosynthesis to oxidative stress or cellular paralysis. Toxins are often enzyme inhibitors, or interfere with cell membrane receptors. 4. The ecological roles of allelopathic compounds have been well identified in several cases, but those of toxins are still debated. In the light of descriptions of negative effects of toxins on both micro-invertebrates and photoautotrophic organisms, we suggest that at least some toxins should actually be considered as allelopathic compounds. Further research on toxic secondary metabolites in freshwaters is now needed, with emphasis on the ecological effects of the compounds in the immediate environment of the emitter algae.

Journal ArticleDOI
E. Tatulli1, E. Tatulli2, Florentin Millour2, Florentin Millour3, Alain Chelli2, Gilles Duvert2, Bram Acke2, Bram Acke4, O. Hernandez Utrera2, Karl-Heinz Hofmann5, Stefan Kraus5, Fabien Malbet2, P. Mège2, Romain Petrov, Martin Vannier, G. Zins2, P. Antonelli, Udo Beckmann5, Y. Bresson, M. Dugué, Sandro Gennari1, L. Glück2, P. Kern2, S. Lagarde, E. Le Coarer2, Franco Lisi1, Karine Perraut2, Pascal Puget2, Fredrik T. Rantakyrö6, S. Robbe-Dubois, A. Roussel, Gerd Weigelt5, M. Accardo1, K. Agabi3, E. Altariba2, B. Arezki2, Eric Aristidi, Carlo Baffa1, J. Behrend5, T. Blöcker5, S. Bonhomme, S. Busoni1, Frédéric Cassaing, J. M. Clausse, J. Colin, C. Connot5, A. Delboulbé2, A. Domiciano de Souza, Thomas Driebe5, P. Feautrier2, D. Ferruzzi1, T. Forveille2, E. Fossat, R. Foy7, Didier Fraix-Burnet2, A. Gallardo2, Elisabetta Giani1, C. Gil2, C. Gil8, A. Glentzlin7, M. Heiden5, M. Heininger5, D. Kamm, Mario Kiekebusch6, D. Le Contel7, J. M. Le Contel7, T. Lesourd7, Bruno Lopez, Morgan Lopez7, Y. Magnard2, Alessandro Marconi1, G. Mars, G. Martinot-Lagarde, Philippe Mathias, J. L. Monin2, D. Mouillet9, D. Mouillet2, Denis Mourard, E. Nussbaum5, Keiichi Ohnaka5, J. A. de Freitas Pacheco, C. Perrier2, Yves Rabbia, S. Rebattu, François Reynaud10, Andrea Richichi6, A. Robini, M. Sacchettini2, Dieter Schertl5, Markus Schöller6, W. Solscheid5, A. Spang, Ph. Stee, P. Stefanini1, Michel Tallon7, Isabelle Tallon-Bosc7, D. Tasso7, Leonardo Testi1, F. Vakili, O. von der Lühe11, J.-C. Valtier, N. Ventura2 
TL;DR: In this article, a data reduction method for single-mode interferometry is presented based on a direct modelling of the fringes in the detector plane, which can be derived for any single-source interferometer.
Abstract: Aims. In this paper, we present an innovative data reduction method for single-mode interferometry. It has been specifically developed for the AMBER instrument, the three-beam combiner of the Very Large Telescope Interferometer, but it can be derived for any single-mode interferometer. Methods. The algorithm is based on a direct modelling of the fringes in the detector plane. As such, it requires a preliminary calibration of the instrument in order to obtain the calibration matrix that builds the linear relationship between the interferogram and the interferometric observable, which is the complex visibility. Once the calibration procedure has been performed, the signal processing appears to be a classical least-square determination of a linear inverse problem. From the estimated complex visibility, we derive the squared visibility, the closure phase, and the spectral differential phase. Results. The data reduction procedures have been gathered into the so-called amdlib software, now available for the community, and are presented in this paper. Furthermore, each step in this original algorithm is illustrated and discussed from various on-sky observations conducted with the VLTI, with a focus on the control of the data quality and the effective execution of the data reduction procedures. We point out the present limited performances of the instrument due to VLTI instrumental vibrations which are difficult to calibrate.

Journal ArticleDOI
TL;DR: In this paper, the structural and optical properties of lattice-matching AlInN layers to GaN have been investigated and their specific use to realize nearly strain-free structures for photonic and electronic applications has been discussed.
Abstract: We report on the current properties of Al1-x InxN (x approximate to 0.18) layers lattice- matched ( LM) to GaN and their specific use to realize nearly strain- free structures for photonic and electronic applications. Following a literature survey of the general properties of AlInN layers, structural and optical properties of thin state- of- the- art AlInN layers LM to GaN are described showing that despite improved structural properties these layers are still characterized by a typical background donor concentration of ( 1 - 5) x 10(18) cm(-3) and a large Stokes shift (similar to 800 meV) between luminescence and absorption edge. The use of these AlInN layers LM to GaN is then exemplified through the properties of GaN/ AlInN multiple quantum wells ( QWs) suitable for near- infrared intersubband applications. A built- in electric field of 3.64MVcm(-1) solely due to spontaneous polarization is deduced from photoluminescence measurements carried out on strain- free single QW heterostructures, a value in good agreement with that deduced from theoretical calculation. Other potentialities regarding optoelectronics are demonstrated through the successful realization of crack- free highly reflective AlInN/ GaN distributed Bragg reflectors ( R > 99%) and high quality factor microcavities ( Q > 2800) likely to be of high interest for short wavelength vertical light emitting devices and fundamental studies on the strong coupling regime between excitons and cavity photons. In this respect, room temperature ( RT) lasing of a LM AlInN/ GaN vertical cavity surface emitting laser under optical pumping is reported. A description of the selective lateral oxidation of AlInN layers for current confinement in nitride- based light emitting devices and the selective chemical etching of oxidized AlInN layers is also given. Finally, the characterization of LM AlInN/ GaN heterojunctions will reveal the potential of such a system for the fabrication of high electron mobility transistors through the report of a high two- dimensional electron gas sheet carrier density ( n(s) similar to 2.6 x 10(13) cm(-2)) combined with a RT mobility mu(e) similar to 1170 cm(2) V-1 s(-1) and a low sheet resistance, R similar to 210 Omega square.

Journal ArticleDOI
15 Mar 2007-Nature
TL;DR: The key role of the PSC in controlling blood cell homeostasis is reminiscent of interactions between haematopoietic progenitors and their micro-environment in vertebrates, thus further highlighting the interest of Drosophila as a model system for studying the evolution of haem atopoiesis and cellular innate immunity.
Abstract: Drosophila haemocytes (blood cells) originate from a specialized haematopoietic organ-the lymph gland. Larval haematopoietic progenitors (prohaemocytes) give rise to three types of circulating haemocytes: plasmatocytes, crystal cells and lamellocytes. Lamellocytes, which are devoted to encapsulation of large foreign bodies, only differentiate in response to specific immune threats, such as parasitization by wasps. Here we show that a small cluster of signalling cells, termed the PSC (posterior signalling centre), controls the balance between multipotent prohaemocytes and differentiating haemocytes, and is necessary for the massive differentiation of lamellocytes that follows parasitization. Communication between the PSC and haematopoietic progenitors strictly depends on the PSC-restricted expression of Collier, the Drosophila orthologue of mammalian early B-cell factor. PSC cells act, in a non-cell-autonomous manner, to maintain JAK/STAT signalling activity in prohaemocytes, preventing their premature differentiation. Serrate-mediated Notch signalling from the PSC is required to maintain normal levels of col transcription. The key role of the PSC in controlling blood cell homeostasis is reminiscent of interactions between haematopoietic progenitors and their micro-environment in vertebrates, thus further highlighting the interest of Drosophila as a model system for studying the evolution of haematopoiesis and cellular innate immunity.

Journal ArticleDOI
21 Feb 2007-PLOS ONE
TL;DR: It is proposed that TBDR overrepresentation and the presence of CUT loci designate the ability to scavenge carbohydrates, which might play a very important role in the biogeochemical cycling of plant-derived nutrients in marine environments.
Abstract: TonB-dependent receptors (TBDRs) are outer membrane proteins mainly known for the active transport of iron siderophore complexes in Gram-negative bacteria. Analysis of the genome of the phytopathogenic bacterium Xanthomonas campestris pv. campestris (Xcc), predicts 72 TBDRs. Such an overrepresentation is common in Xanthomonas species but is limited to only a small number of bacteria. Here, we show that one Xcc TBDR transports sucrose with a very high affinity, suggesting that it might be a sucrose scavenger. This TBDR acts with an inner membrane transporter, an amylosucrase and a regulator to utilize sucrose, thus defining a new type of carbohydrate utilization locus, named CUT locus, involving a TBDR for the transport of substrate across the outer membrane. This sucrose CUT locus is required for full pathogenicity on Arabidopsis, showing its importance for the adaptation to host plants. A systematic analysis of Xcc TBDR genes and a genome context survey suggested that several Xcc TBDRs belong to other CUT loci involved in the utilization of various plant carbohydrates. Interestingly, several Xcc TBDRs and CUT loci are conserved in aquatic bacteria such as Caulobacter crescentus, Colwellia psychrerythraea, Saccharophagus degradans, Shewanella spp., Sphingomonas spp. or Pseudoalteromonas spp., which share the ability to degrade a wide variety of complex carbohydrates and display TBDR overrepresentation. We therefore propose that TBDR overrepresentation and the presence of CUT loci designate the ability to scavenge carbohydrates. Thus CUT loci, which seem to participate to the adaptation of phytopathogenic bacteria to their host plants, might also play a very important role in the biogeochemical cycling of plant-derived nutrients in marine environments. Moreover, the TBDRs and CUT loci identified in this study are clearly different from those characterized in the human gut symbiont Bacteroides thetaiotaomicron, which allow glycan foraging, suggesting a convergent evolution of TBDRs in Proteobacteria and Bacteroidetes.

Journal ArticleDOI
TL;DR: In this paper, the authors prove the algebraicity of the group of auto-equivalences of saturated dg-categories and prove the existence of reasonable moduli for perfect complexes on a smooth and proper scheme.
Abstract: The purpose of this work is to prove the existence of an algebraic moduli classifying objects in a given triangulated category. To any dg-category T (over some base ring k), we define a D -stack MT in the sense of [HAGII], classifying certain T op -dg-modules. When T is saturated, MT classifies compact objects in the triangulated category [T] associated to T. The main result of this work states that under certain finiteness conditions on T (e.g. if it is saturated) the D -stack MT is locally geometric (i.e. union of open and geometric sub-stacks). As a consequence we prove the algebraicity of the group of auto-equivalences of saturated dg-categories. We also obtain the existence of reasonable moduli for perfect complexes on a smooth and proper scheme, as well as complexes of representations of a finite quiver.

Journal ArticleDOI
TL;DR: In this paper, a sample of 28 well-known spectroscopically-identified magnetic Ap/Bp stars, with weak, poorly-determined or previously undetected magnetic fields, was used to explore the weak part of the magnetic field distribution of Ap/bp stars.
Abstract: Aims. We investigated a sample of 28 well-known spectroscopically-identified magnetic Ap/Bp stars, with weak, poorly-determined or previously undetected magnetic fields. The aim of this study is to explore the weak part of the magnetic field distribution of Ap/Bp stars. Methods. Using the MuSiCoS and NARVAL spectropolarimeters at Telescope Bernard Lyot (Observatoire du Pic du Midi, France) and the cross-correlation technique Least Squares Deconvolution (LSD), we obtained 282 LSD Stokes V signatures of our 28 sample stars, in order to detect the magnetic field and to infer its longitudinal component with high precision (median σ = 40 G). Results. For the 28 studied stars, we obtained 27 detections of StokesV Zeeman signatures from the MuSiCoS observations. Detection of the Stokes V signature of the 28th star (HD 32650) was obtained during science demonstration time of the new NARVAL spectropolarimeter at Pic du Midi. This result clearly shows that when observed with sufficient precision, all firmly classified Ap/Bp stars show detectable surface magnetic fields. Furthermore, all detected magnetic fields correspond to longitudinal fields which are significantly greater than some tens of G. To better characterise the surface magnetic field intensities and geometries of the sample, we phased the longitudinal field measurements of each star using new and previously-published rotational periods, and modeled them to infer the dipolar field intensity (Bd, measured at the magnetic pole) and the magnetic obliquity (β). The distribution of derived dipole strengths for these stars exhibits a plateau at about 1 kG, falling off to larger and smaller field strengths. Remarkably, in this sample of stars selected for their presumably weak magnetic fields, we find only 2 stars for which the derived dipole strength is weaker than 300 G. We interpret this “magnetic threshold” as a critical value necessary for the stability of large-scale magnetic fields, and develop a simple quantitative model that is able to approximately reproduce the observed threshold characteristics. This scenario leads to a natural explanation of the small fraction of intermediate-mass magnetic stars. It may also explain the near-absence of magnetic fields in more massive B and O-type stars.

Journal ArticleDOI
TL;DR: In this paper, a kinetic mean-field version of the Couzin-Vicsek algorithm is proposed and its formal macroscopic limit is derived based on a collisional invariant of a collision operator.
Abstract: We consider the discrete Couzin-Vicsek algorithm (CVA), which describes the interactions of individuals among animal societies such as fish schools. In this article, we propose a kinetic (mean-field) version of the CVA model and provide its formal macroscopic limit. The final macroscopic model involves a conservation equation for the density of the individuals and a non conservative equation for the director of the mean velocity and is proved to be hyperbolic. The derivation is based on the introduction of a non-conventional concept of a collisional invariant of a collision operator.

Journal ArticleDOI
TL;DR: In this paper, the largest eigenvalue of a complex Deformed Wigner Ensemble has been studied and the universality of the fluctuations has been established based on the moments of traces of high powers of the random matrices under consideration.
Abstract: The purpose of this paper is to establish universality of the fluctuations of the largest eigenvalue for some non-necessarily Gaussian complex Deformed Wigner Ensembles. The real model is also considered. Our approach is close to the one used by A. Soshnikov (cf. [11]) in the investigations of classical real or complex Wigner Ensembles. It is based on the computation of moments of traces of high powers of the random matrices under consideration.

Journal ArticleDOI
TL;DR: Genetic and biochemical analyses have greatly expanded knowledge of chaperone tasking in Escherichia coli K‐12, and recent advances in structure determination have led to significant insights of the underlying complexities and functional elegance of the Hsp70 chaperones machine.
Abstract: Molecular chaperones are highly conserved in all free-living organisms. There are many types of chaperones, and most are conveniently grouped into families. Genome sequencing has revealed that many organisms contain multiple members of both the DnaK (Hsp70) family and their partner J-domain protein (JDP) cochaperone, belonging to the DnaJ (Hsp40) family. Escherichia coli K-12 encodes three Hsp70 genes and six JDP genes. The coexistence of these chaperones in the same cytosol suggests that certain chaperone-cochaperone interactions are permitted, and that chaperone tasks and their regulation have become specialized over the course of evolution. Extensive genetic and biochemical analyses have greatly expanded knowledge of chaperone tasking in this organism. In particular, recent advances in structure determination have led to significant insights of the underlying complexities and functional elegance of the Hsp70 chaperone machine.

Journal ArticleDOI
TL;DR: Whether these processes are fundamentally different from the more traditional 'chemical warfare' among bacteria are discussed and discussed.
Abstract: Cannibalism and fratricide refer to the killing of genetically identical cells (siblings) that was recently documented in two Gram-positive species, Bacillus subtilis and Streptococcus pneumoniae, respectively. Cannibalism occurs during the early stages of sporulation in B. subtilis, whereas fratricide occurs in S. pneumoniae during natural genetic transformation. Here, we compare and contrast these two phenomena and discuss whether these processes are fundamentally different from the more traditional 'chemical warfare' among bacteria.

Journal ArticleDOI
13 Sep 2007-Nature
TL;DR: The detection of a planet orbiting a post-red-giant star demonstrates that planets with orbital distances of less than 2 au can survive the red-Giant expansion of their parent stars.
Abstract: After the initial discoveries fifteen years ago, over 200 extrasolar planets have now been detected. Most of them orbit main-sequence stars similar to our Sun, although a few planets orbiting red giant stars have been recently found. When the hydrogen in their cores runs out, main-sequence stars undergo an expansion into red-giant stars. This expansion can modify the orbits of planets and can easily reach and engulf the inner planets. The same will happen to the planets of our Solar System in about five billion years and the fate of the Earth is matter of debate. Here we report the discovery of a planetary-mass body (Msini = 3.2M_(Jupiter)) orbiting the star V 391 Pegasi at a distance of about 1.7 astronomical units (au), with a period of 3.2 years. This star is on the extreme horizontal branch of the Hertzsprung–Russell diagram, burning helium in its core and pulsating. The maximum radius of the red-giant precursor of V 391 Pegasi may have reached 0.7 au, while the orbital distance of the planet during the stellar main-sequence phase is estimated to be about 1 au. This detection of a planet orbiting a post-red-giant star demonstrates that planets with orbital distances of less than 2 au can survive the red-giant expansion of their parent stars.

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TL;DR: In this paper, the Cepheid Period-Luminosity relations have been studied in various photometric bands (from B to K) and compared to the well-established PL relations in the LMC.
Abstract: Context. The universality of the Cepheid Period-Luminosity relations has been under discussion since metallicity effects have been assumed to play a role in the value of the intercept and, more recently, of the slope of these relations. Aims. The goal of the present study is to calibrate the Galactic PL relations in various photometric bands (from B to K) and to compare the results to the well-established PL relations in the LMC. Methods. We use a set of 59 calibrating stars, the distances of which are measured using five different distance indicators: Hubble Space Telescope and revised Hipparcos parallaxes, infrared surface brightness and interferometric Baade-Wesselink parallaxes, and classical Zero-Age-Main-Sequence-fitting parallaxes for Cepheids belonging to open clusters or OB stars associations. A detailed discussion of absorption corrections and projection facto r to be used is given. Results. We find no significant di fference in the slopes of the PL relations between LMC and our Galaxy. Conclusions. We conclude that the Cepheid PL relations have universal slopes in all photometric bands, n ot depending on the galaxy under study (at least for LMC and Milky Way). The possible zero-point variation with metal content is not discussed in the present work, but an upper limit of 18.50 for the LMC distance modulus can be deduced from our data.

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TL;DR: In this article, the degenerate complex Monge-Ampere equations on a compact Kahler manifold (X, ω ) were studied and it was shown that the complex operator ( ω + d d c ⋅ ) n is well defined on the class of ω -plurisubharmonic functions with finite weighted monge-ampere energy.

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TL;DR: Recommendations for dosing adjustments for cancer drugs in this population according to renal function are outlined, with a focus on drugs which are renally eliminated or are known to be nephrotoxic.