San Francisco State University

About: San Francisco State University is a education organization based out in San Francisco, California, United States. It is known for research contribution in the topics: Population & Planet. The organization has 5669 authors who have published 11433 publications receiving 408075 citations. The organization is also known as: San Francisco State & San Francisco State Normal School.

Pluses and minuses of ammonium and nitrate uptake and assimilation by phytoplankton and implications for productivity and community composition, with emphasis on nitrogen-enriched conditions

Abstract: Anthropogenic activities are altering total nutrient loads to many estuaries and freshwaters, resulting in high loads not only of total nitrogen (N), but in some cases, of chemically reduced forms, notably NH4+. Long thought to be the preferred form of N for phytoplankton uptake, NH4+ may actually suppress overall growth when concentrations are sufficiently high. NH4+ has been well known to be inhibitory or repressive for NO3‐ uptake and assimilation, but the concentrations of NH4+ that promote vs. repress NO3‐ uptake, assimilation, and growth in different phytoplankton groups and under different growth conditions are not well understood. Here, we review N metabolism first in a “generic” eukaryotic cell, and the contrasting metabolic pathways and regulation of NH4+ and NO3− when these substrates are provided individually under equivalent growth conditions. Then the metabolic interactions of these substrates are described when both are provided together, emphasizing the cellular challenge of balancing nutrient acquisition with photosynthetic energy balance in dynamic environments. Conditions under which dissipatory pathways such as dissimilatory NO3−/ NO2− reduction to NH4+ and photorespiration that may lead to growth suppression are highlighted. While more is known about diatoms, taxon-specific differences in NH4+ and NO3− metabolism that may contribute to changes in phytoplankton community composition when the composition of the N pool changes are presented. These relationships have important implications for harmful algal blooms, development of nutrient criteria for management, and modeling of nutrient uptake by phytoplankton, particularly in conditions where eutrophication is increasing and the redox state of N loads is changing.

Thermoelectric transport in disordered metals without quasiparticles: The Sachdev-Ye-Kitaev models and holography

Abstract: We compute the thermodynamic properties of the Sachdev-Ye-Kitaev (SYK) models of fermions with a conserved fermion number Q. We extend a previously proposed Schwarzian effective action to include a phase field, and this describes the low-temperature energy and Q fluctuations. We obtain higher-dimensional generalizations of the SYK models which display disordered metallic states without quasiparticle excitations, and we deduce their thermoelectric transport coefficients. We also examine the corresponding properties of Einstein-Maxwell-axion theories on black brane geometries which interpolate from either AdS4 or AdS5 to an AdS2×R2 or AdS2×R3 near-horizon geometry. These provide holographic descriptions of nonquasiparticle metallic states without momentum conservation. We find a precise match between low-temperature transport and thermodynamics of the SYK and holographic models. In both models, the Seebeck transport coefficient is exactly equal to the Q derivative of the entropy. For the SYK models, quantum chaos, as characterized by the butterfly velocity and the Lyapunov rate, universally determines the thermal diffusivity, but not the charge diffusivity.

Influence of sulfide inhibition of nitrification on nitrogen regeneration in sediments

Abstract: Nitrification, a central process in the nitrogen cycle, converts ammonium to nitrite or nitrate. In experiments with estuarine sediment, addition of 60 and 100 μM hydrogen sulfide (HS − ) reduced nitrification by 50 and 100 percent, respectively. Aerobic incubation of ammonium-enriched sediment slurries showed that previous HS − exposure reduced nitrification for at least 24 hours; nitrification rates recovered slowly after one-time HS − exposure. Sulfide inhibition of nitrification could limit nitrogen loss through coupled nitrification-denitrification and may contribute to the previously observed difference in net nitrogen cycling between freshwater and marine sediments. This interaction could also exacerbate eutrophication in coastal environments.

Aquaporins: important but elusive drug targets

Abstract: The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators.

Phylogenetic compositions of bacterioplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments.

Abstract: The phylogenetic compositions of bacterioplankton assemblages from San Francisco Bay and Tomales Bay, Calif., differed substantially when analyzed by PCR-denaturing gradient gel electrophoresis; these differences are consistent with the results of previous studies demonstrating differences in their metabolic capabilities. PCR-denaturing gradient gel electrophoresis analysis of complex microbial assemblages was sensitive and reliable, and the results were reproducible as shown by experiments with constructed and naturally occurring assemblages.