Sao Paulo State University

About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.

Evidence for transverse-momentum- and pseudorapidity-dependent event-plane fluctuations in PbPb and pPb collisions

Abstract: A systematic study of the factorization of long-range azimuthal two-particle correlations into a product of single-particle anisotropies is presented as a function of pT and nu of both particles and as a function of the particle multiplicity in PbPb and pPb collisions. The data were taken with the CMS detector for PbPb collisions at root sNN = 2.76 TeV and pPb collisions at root sNN = 5.02 TeV, covering a very wide range of multiplicity. Factorization is observed to be broken as a function of both particle pT and nu. When measured with particles of different pT, the magnitude of the factorization breakdown for the second Fourier harmonic reaches 20% for very central PbPb collisions but decreases rapidly as the multiplicity decreases. The data are consistent with viscous hydrodynamic predictions, which suggest that the effect of factorization breaking is mainly sensitive to the initial-state conditions rather than to the transport properties (e.g., shear viscosity) of the medium. The factorization breakdown is also computed with particles of different nu. The effect is found to be weakest for mid-central PbPb events but becomes larger for more central or peripheral PbPb collisions, and also for very-high-multiplicity pPb collisions. The nu-dependent factorization data provide new insights to the longitudinal evolution of the medium formed in heavy ion collisions.

Everyman's Guide to Bacterial Insertion Sequences

Abstract: The number and diversity of known prokaryotic insertion sequences (IS) have increased enormously since their discovery in the late 1960s. At present the sequences of more than 4000 different IS have been deposited in the specialized ISfinder database. Over time it has become increasingly apparent that they are important actors in the evolution of their host genomes and are involved in sequestering, transmitting, mutating and activating genes, and in the rearrangement of both plasmids and chromosomes. This review presents an overview of our current understanding of these transposable elements (TE), their organization and their transposition mechanism as well as their distribution and genomic impact. In spite of their diversity, they share only a very limited number of transposition mechanisms which we outline here. Prokaryotic IS are but one example of a variety of diverse TE which are being revealed due to the advent of extensive genome sequencing projects. A major conclusion from sequence comparisons of various TE is that frontiers between the different types are becoming less clear. We detail these receding frontiers between different IS-related TE. Several, more specialized chapters in this volume include additional detailed information concerning a number of these. In a second section of the review, we provide a detailed description of the expanding variety of IS, which we have divided into families for convenience. Our perception of these families continues to evolve and families emerge regularly as more IS are identified. This section is designed as an aid and a source of information for consultation by interested specialist readers.

Non-Markovianity through Accessible Information

Abstract: The degree of non-Markovianity of quantum processes has been characterized in several different ways in the recent literature. However, the relationship between the non-Markovian behavior and the flow of information between the system and the environment through an entropic measure has not been yet established. We propose an entanglement-based measure of non-Markovianity by employing the concept of assisted knowledge, where the environment $\mathcal{E}$, acquires information about a system $\mathcal{S}$, by means of its measurement apparatus $\mathcal{A}$. The assisted knowledge, based on the accessible information in terms of von Neumann entropy, monotonically increases in time for all Markovian quantum processes. We demonstrate that the signatures of non-Markovianity can be captured by the nonmonotonic behavior of the assisted knowledge. We explore this scenario for a two-level system undergoing a relaxation process, through an experimental implementation using an optical approach that allows full access to the state of the environment.

Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment.

Abstract: Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are affected by this disease and the tendency is that this number will increase to 62% by 2030. Two microscopic features assist in the characterization of the disease, the amyloid plaques and neurofibrillary agglomerates. All these factors are responsible for the slow and gradual deterioration of memory that affect language, personality or cognitive control. For the AD diagnosis, neuropsychological tests are performed in different spheres of cognitive functions but since not all cognitive functions may be affected, cerebrospinal fluid biomarkers are used along with these tests. To date, cholinesterase inhibitors are used as treatment, they are the only drugs that have shown significant improvements in the cognitive functions of AD patients. Despite the proven effectiveness of cholinesterase inhibitors, an AD carrier, even while being treated, is continually subjected to progressive degeneration of the neuronal tissue. For this reason, other biochemical pathways associated with the pathophysiology of AD have been explored as alternatives to the treatment of this condition such as inhibition of β-secretase and glycogen synthase kinase-3β. The present study aims to conduct a review of the epidemiology, pathophysiology, symptoms, diagnosis and treatment of Alzheimer's disease, emphasizing the research and development of new therapeutic approaches.