Institution
University of Texas Medical Branch
Education•Galveston, Texas, United States•
About: University of Texas Medical Branch is a education organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Population & Virus. The organization has 22033 authors who have published 38268 publications receiving 1517502 citations. The organization is also known as: The University of Texas Medical Branch at Galveston & UTMB.
Topics: Population, Virus, Immune system, Receptor, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The studies demonstrated that microbiota metabolites SCFA promoted IEC RegIIIγ and β-defensins in a GPR43-dependent manner, providing a novel pathway by which microbiota regulates IEC expression of AMP and intestinal homeostasis.
273 citations
Journal Article•
TL;DR: The results suggest that resistance to epipodophyllotoxins in MCF7/VP cells is multifactorial, involving a reduction in intracellular drug concentration, possibly as a consequence of MRP overexpression, and an altered DNA topoisomerase II drug sensitivity.
Abstract: A human breast cancer cell line (MCF7/WT) was selected for resistance to etoposide (VP-16) by stepwise exposure to 2-fold increasing concentrations of this agent. The resulting cell line (MCF7/VP) was 28-, 21-, and 9-fold resistant to VP-16, VM-26, and doxorubicin, respectively. MCF7/VP cells also exhibited low-level cross-resistance to 4'-(9-acridinylamino)-methanesulfon-m-anisidide, mitoxantrone, and vincristine and no cross-resistance to genistein and camptothecin. Furthermore, these cells were collaterally sensitive to the alkylating agents melphalan and chlorambucil. DNA topoisomerase II levels were similar in both wild-type MCF7/WT and drug-resistant MCF7/VP cells. In contrast, topoisomerase II from MCF7/VP cells appeared to be 7-fold less sensitive to drug-induced cleavable complex formation in whole cells and 3-fold less sensitive in nuclear extracts than topoisomerase II from MCF7/WT cells. Although this suggested that the resistant cells may contain a qualitatively altered topoisomerase II, no mutations were detected in either the ATP-binding nor the putative breakage/resealing regions of either DNA topoisomerase II alpha or II beta. In addition, the steady-state intracellular VP-16 concentration was reduced by 2-fold in the resistant cells, in the absence of detectable mdr1/P-gp expression and without any change in drug efflux. In contrast, expression of the gene encoding the MRP was increased at least 10-fold in resistant MCF7/VP cells as compared to sensitive MCF7/WT cells. These results suggest that resistance to epipodophyllotoxins in MCF7/VP cells is multifactorial, involving a reduction in intracellular drug concentration, possibly as a consequence of MRP overexpression, and an altered DNA topoisomerase II drug sensitivity.
272 citations
TL;DR: Its dynamic aerosol efficiency surpassed those of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome and its findings suggest retained infectivity and virion integrity for up to 16 hours in respirable-sized aerosols.
Abstract: We aerosolized severe acute respiratory syndrome coronavirus 2 and determined that its dynamic aerosol efficiency surpassed those of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome Although we performed experiment only once across several laboratories, our findings suggest retained infectivity and virion integrity for up to 16 hours in respirable-sized aerosols
272 citations
University of Missouri1, Auburn University2, Prefectural University of Kumamoto3, University of Cincinnati4, Charité5, Maryville College6, University of Siena7, University of Florida8, Washington State University9, National Institutes of Natural Sciences, Japan10, Brunel University London11, University of Connecticut12, Emory University13, Goethe University Frankfurt14, University of Granada15, University of Parma16, Tufts University17, University of Würzburg18, North Carolina State University19, Chemical Heritage Foundation20, University of Texas Medical Branch21, University of Massachusetts Amherst22
TL;DR: Differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories are reviewed to identify hazards and molecular mechanisms mediating adverse effects.
Abstract: BackgroundIn their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special pr...
272 citations
TL;DR: A structural mechanism whereby ligand-induced conformational changes may coordinate catalytic activity is suggested, as well as insights into the dynamics involved in substrate access, tight inhibitor binding, and coordination of substrate and redox partner binding.
272 citations
Authors
Showing all 22143 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stuart H. Orkin | 186 | 715 | 112182 |
| Eric R. Kandel | 184 | 603 | 113560 |
| John C. Morris | 183 | 1441 | 168413 |
| Joseph Biederman | 179 | 1012 | 117440 |
| Richard A. Gibbs | 172 | 889 | 249708 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Gabriel N. Hortobagyi | 166 | 1374 | 104845 |
| Roberto Romero | 151 | 1516 | 108321 |
| Charles B. Nemeroff | 149 | 979 | 90426 |
| Peter J. Schwartz | 147 | 647 | 107695 |
| Clifford J. Woolf | 141 | 509 | 86164 |
| Thomas J. Smith | 140 | 1775 | 113919 |
| Edward C. Holmes | 138 | 824 | 85748 |
| Jun Lu | 135 | 1526 | 99767 |
| Henry T. Lynch | 133 | 925 | 86270 |