University of Western Australia

About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.

The Human Phenotype Ontology in 2021

Abstract: The Human Phenotype Ontology (HPO, https://hpo.jax.org) was launched in 2008 to provide a comprehensive logical standard to describe and computationally analyze phenotypic abnormalities found in human disease. The HPO is now a worldwide standard for phenotype exchange. The HPO has grown steadily since its inception due to considerable contributions from clinical experts and researchers from a diverse range of disciplines. Here, we present recent major extensions of the HPO for neurology, nephrology, immunology, pulmonology, newborn screening, and other areas. For example, the seizure subontology now reflects the International League Against Epilepsy (ILAE) guidelines and these enhancements have already shown clinical validity. We present new efforts to harmonize computational definitions of phenotypic abnormalities across the HPO and multiple phenotype ontologies used for animal models of disease. These efforts will benefit software such as Exomiser by improving the accuracy and scope of cross-species phenotype matching. The computational modeling strategy used by the HPO to define disease entities and phenotypic features and distinguish between them is explained in detail.We also report on recent efforts to translate the HPO into indigenous languages. Finally, we summarize recent advances in the use of HPO in electronic health record systems.

A Comprehensive Performance Evaluation of 3D Local Feature Descriptors

Abstract: A number of 3D local feature descriptors have been proposed in the literature. It is however, unclear which descriptors are more appropriate for a particular application. A good descriptor should be descriptive, compact, and robust to a set of nuisances. This paper compares ten popular local feature descriptors in the contexts of 3D object recognition, 3D shape retrieval, and 3D modeling. We first evaluate the descriptiveness of these descriptors on eight popular datasets which were acquired using different techniques. We then analyze their compactness using the recall of feature matching per each float value in the descriptor. We also test the robustness of the selected descriptors with respect to support radius variations, Gaussian noise, shot noise, varying mesh resolution, distance to the mesh boundary, keypoint localization error, occlusion, clutter, and dataset size. Moreover, we present the performance results of these descriptors when combined with different 3D keypoint detection methods. We finally analyze the computational efficiency for generating each descriptor.

Review of automotive brake friction materials

Abstract: The gradual phasing-out of asbestos in automotive brake friction materials in many parts of the world has sparked the onset of extensive research and development into safer alternatives. As a result, the brake friction industry has seen the birth of different brake pads and shoes in the past decade, each with their own unique composition, yet performing the very same task and claiming to be better than others. This suggests that the selection of brake friction materials is based more on tradition and experimental trial and error rather than fundamental understanding. This review strives to eliminate the cloud of uncertainty by providing an insight into the pros and cons of the common ingredients and make-up used in contemporary dry and wet friction pads and shoes. In this paper typical brake materials are reviewed and their advantages and disadvantages in contemporary brake applications are discussed.

The continental record and the generation of continental crust

Abstract: Continental crust is the archive of Earth history. The spatial and temporal distribution of Earth’s record of rock units and events is heterogeneous; for example, ages of igneous crystallization, metamorphism, continental margins, mineralization, and sea water and atmospheric proxies are distributed about a series of peaks and troughs. This distribution refl ects the different preservation potential of rocks generated in different tectonic settings, rather than fundamental pulses of activity, and the peaks of ages are linked to the timing of supercontinent assembly. The physiochemical resilience of zircons and their derivation largely from felsic igneous rocks means that they are important indicators of the crustal record. Furthermore, detrital zircons, which sample a range of source rocks, provide a more representative record than direct analysis of grains in igneous rocks. Analysis of detrital zircons suggests that at least ~60%–70% of the present volume of the continental crust had been generated by 3 Ga. Such estimates seek to take account of the extent to which the old crustal material is underrepresented in the sedimentary record , and they imply that there were greater volumes of continental crust in the Archean than might be inferred from the compositions of detrital zircons and sediments. The growth of continental crust was a continuous rather than an episodic process, but there was a marked decrease in the rate of crustal growth at ca. 3 Ga, which may have been linked to the onset of signifi cant crustal recycling, probably through subduction at convergent plate margins. The Hadean and Early Archean continental record is poorly preserved and characterized by a bimodal TTG (tonalites, trondhjemites, and granodiorites) and greenstone association that differs from the younger record that can be more directly related to a plate-tectonic regime. The paucity of this early record has led to competing and equivocal models invoking plate-tectonic– and mantle-plume–dominated processes. The 60%–70% of the present volume of the continental crust estimated to have been present at 3 Ga contrasts markedly with the <10% of crust of that age apparently still preserved and requires on going destruction (recycling) of crust and subconti nental mantle lithosphere back into the mantle through processes such as subduction and delamination.