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Institution

University of Western Australia

EducationPerth, Western Australia, Australia
About: University of Western Australia is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 29613 authors who have published 87405 publications receiving 3064466 citations. The organization is also known as: UWA & University of WA.


Papers
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Journal ArticleDOI
TL;DR: If current trends continue, the 2025 global physical activity target (a 10% relative reduction in insufficient physical activity) will not be met and policies to increase population levels of physical activity need to be prioritised and scaled up urgently.

2,358 citations

Journal ArticleDOI
02 May 2008-Cell
TL;DR: Deep sequencing of smRNAs revealed a direct relationship between the location of sm RNAs and DNA methylation, perturbation of smRNA biogenesis upon loss of CpG DNA methylisation, and a tendency for smRN as to direct strand-specific DNA methylations in regions of RNA-DNA homology.

2,349 citations

Journal ArticleDOI
28 Nov 2014-Science
TL;DR: Diversity of most fungal groups peaked in tropical ecosystems, but ectomycorrhizal fungi and several fungal classes were most diverse in temperate or boreal ecosystems, and manyfungal groups exhibited distinct preferences for specific edaphic conditions (such as pH, calcium, or phosphorus).
Abstract: Fungi play major roles in ecosystem processes, but the determinants of fungal diversity and biogeographic patterns remain poorly understood. Using DNA metabarcoding data from hundreds of globally distributed soil samples, we demonstrate that fungal richness is decoupled from plant diversity. The plant-to-fungus richness ratio declines exponentially toward the poles. Climatic factors, followed by edaphic and spatial variables, constitute the best predictors of fungal richness and community composition at the global scale. Fungi show similar latitudinal diversity gradients to other organisms, with several notable exceptions. These findings advance our understanding of global fungal diversity patterns and permit integration of fungi into a general macroecological framework.

2,346 citations

Journal ArticleDOI
TL;DR: In this paper, the authors identify key areas of uncertainty and specific actions needed to address them and identify the value of mangrove forests, seagrass beds, and salt marshes in sequestering carbon dioxide.
Abstract: Recent research has highlighted the valuable role that coastal and marine ecosystems play in sequestering carbon dioxide (CO(2)). The carbon (C) sequestered in vegetated coastal ecosystems, specifically mangrove forests, seagrass beds, and salt marshes, has been termed blue carbon. Although their global area is one to two orders of magnitude smaller than that of terrestrial forests, the contribution of vegetated coastal habitats per unit area to long-term C sequestration is much greater, in part because of their efficiency in trapping suspended matter and associated organic C during tidal inundation. Despite the value of mangrove forests, seagrass beds, and salt marshes in sequestering C, and the other goods and services they provide, these systems are being lost at critical rates and action is urgently needed to prevent further degradation and loss. Recognition of the C sequestration value of vegetated coastal ecosystems provides a strong argument for their protection and restoration; however, it is necessary to improve scientific understanding of the underlying mechanisms that control C sequestration in these ecosystems. Here, we identify key areas of uncertainty and specific actions needed to address them.

2,313 citations

Journal ArticleDOI
TL;DR: The chemistry of advanced glycated end-product formation and their patho-biochemistry particularly in relation to the diabetic microvascular complications of retinopathy, neuropathy and nephropathy as well as their role in the accelerated vasculopathy observed in diabetes are discussed.
Abstract: Advanced glycation end-products are a complex and heterogeneous group of compounds that have been implicated in diabetes related complications At present it is not known if they are the cause or the consequence of the complications observed We discuss the chemistry of advanced glycated end-product formation and their patho-biochemistry particularly in relation to the diabetic microvascular complications of retinopathy, neuropathy and nephropathy as well as their role in the accelerated vasculopathy observed in diabetes The concept of carbonyl stress as a cause for advanced glycated end-product toxicity is mentioned We discuss alterations in the concentrations of advanced glycated end-products in the body, particularly in relation to changes occurring with age, diabetes and its complications such as nephropathy Problems relating to current methods of advanced glycated end-product detection and measurement are highlighted including the lack of a universally established method of detection or unit of measurement Agents used for the treatment of advanced glycated end-product accumulation are reviewed, with an emphasis on the results of the recent phase III trials using aminoguanidine and diabetes related complications

2,308 citations


Authors

Showing all 29972 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
Cornelia M. van Duijn1831030146009
Kay-Tee Khaw1741389138782
Steven N. Blair165879132929
David W. Bates1591239116698
Mark E. Cooper1581463124887
David Cameron1541586126067
Stephen T. Holgate14287082345
Jeremy K. Nicholson14177380275
Xin Chen1391008113088
Graeme J. Hankey137844143373
David Stuart1361665103759
Joachim Heinrich136130976887
Carlos M. Duarte132117386672
David Smith1292184100917
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023138
2022656
20215,967
20205,589
20195,452
20184,923