University of Wisconsin-Madison

About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Gene. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.

Smoothing Methods in Statistics

Abstract: 1. Introduction.- 1.1 Smoothing Methods: a Nonparametric/Parametric Compromise.- 1.2 Uses of Smoothing Methods.- 1.3 Outline of the Chapters.- Background material.- Computational issues.- Exercises.- 2. Simple Univariate Density Estimation.- 2.1 The Histogram.- 2.2 The Frequency Polygon.- 2.3 Varying the Bin Width.- 2.4 The Effectiveness of Simple Density Estimators.- Background material.- Computational issues.- Exercises.- 3. Smoother Univariate Density Estimation.- 3.1 Kernel Density Estimation.- 3.2 Problems with Kernel Density Estimation.- 3.3 Adjustments and Improvements to Kernel Density Estimation.- 3.4 Local Likelihood Estimation.- 3.5 Roughness Penalty and Spline-Based Methods.- 3.6 Comparison of Univariate Density Estimators.- Background material.- Computational issues.- Exercises.- 4. Multivariate Density Estimation.- 4.1 Simple Density Estimation Methods.- 4.2 Kernel Density Estimation.- 4.3 Other Estimators.- 4.4 Dimension Reduction and Projection Pursuit.- 4.5 The State of Multivariate Density Estimation.- Background material.- Computational issues.- Exercises.- 5. Nonparametrie Regression.- 5.1 Scatter Plot Smoothing and Kernel Regression.- 5.2 Local Polynomial Regression.- 5.3 Bandwidth Selection.- 5.4 Locally Varying the Bandwidth.- 5.5 Outliers and Autocorrelation.- 5.6 Spline Smoothing.- 5.7 Multiple Predictors and Additive Models.- 5.8 Comparing Nonparametric Regression Methods.- Background material.- Computational issues.- Exercises.- 6. Smoothing Ordered Categorical Data.- 6.1 Smoothing and Ordered Categorical Data.- 6.2 Smoothing Sparse Multinomials.- 6.3 Smoothing Sparse Contingency Tables.- 6.4 Categorical Data, Regression, and Density Estimation.- Background material.- Computational issues.- Exercises.- 7. Further Applications of Smoothing.- 7.1 Discriminant Analysis.- 7.2 Goodness-of-Fit Tests.- 7.3 Smoothing-Based Parametric Estimation.- 7.4 The Smoothed Bootstrap.- Background material.- Computational issues.- Exercises.- Appendices.- A. Descriptions of the Data Sets.- B. More on Computational Issues.- References.- Author Index.

Alliance in individual psychotherapy.

Abstract: This article reports on a research synthesis of the relation between alliance and the outcomes of individual psychotherapy. Included were over 200 research reports based on 190 independent data sources, covering more than 14,000 treatments. Research involving 5 or more adult participants receiving genuine (as opposed to analogue) treatments, where the author(s) referred to one of the independent variables as “alliance,” “therapeutic alliance,” “helping alliance,” or “working alliance” were the inclusion criteria. All analyses were done using the assumptions of a random model. The overall aggregate relation between the alliance and treatment outcome (adjusted for sample size and non independence of outcome measures) was r .275 (k 190); the 95% confidence interval for this value was .25–.30. The statistical probability associated with the aggregated relation between alliance and outcome is p .0001. The data collected for this meta-analysis were quite variable (heterogeneous). Potential variables such as assessment perspectives (client, therapist, observer), publication source, types of assessment methods and time of assessment were explored.

Structural variation of chromosomes in autism spectrum disorder.

Abstract: Structural variation (copy number variation [CNV] including deletion and duplication, translocation, inversion) of chromosomes has been identified in some individuals with autism spectrum disorder (ASD), but the full etiologic role is unknown. We performed genome-wide assessment for structural abnormalities in 427 unrelated ASD cases via single-nucleotide polymorphism microarrays and karyotyping. With microarrays, we discovered 277 unbalanced CNVs in 44% of ASD families not present in 500 controls (and re-examined in another 1152 controls). Karyotyping detected additional balanced changes. Although most variants were inherited, we found a total of 27 cases with de novo alterations, and in three (11%) of these individuals, two or more new variants were observed. De novo CNVs were found in ∼7% and ∼2% of idiopathic families having one child, or two or more ASD siblings, respectively. We also detected 13 loci with recurrent/overlapping CNV in unrelated cases, and at these sites, deletions and duplications affecting the same gene(s) in different individuals and sometimes in asymptomatic carriers were also found. Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), ANKRD11, DPYD, PTCHD1, 15q24, among others, for a role in ASD susceptibility. Our most compelling result discovered CNV at 16p11.2 (p = 0.002) (with characteristics of a genomic disorder) at ∼1% frequency. Some of the ASD regions were also common to mental retardation loci. Structural variants were found in sufficiently high frequency influencing ASD to suggest that cytogenetic and microarray analyses be considered in routine clinical workup.

Wetland resources : Status, trends, ecosystem services, and restorability

Abstract: ▪ Abstract Estimates of global wetland area range from 5.3 to 12.8 million km2. About half the global wetland area has been lost, but an international treaty (the 1971 Ramsar Convention) has helped 144 nations protect the most significant remaining wetlands. Because most nations lack wetland inventories, changes in the quantity and quality of the world's wetlands cannot be tracked adequately. Despite the likelihood that remaining wetlands occupy less than 9% of the earth's land area, they contribute more to annually renewable ecosystem services than their small area implies. Biodiversity support, water quality improvement, flood abatement, and carbon sequestration are key functions that are impaired when wetlands are lost or degraded. Restoration techniques are improving, although the recovery of lost biodiversity is challenged by invasive species, which thrive under disturbance and displace natives. Not all damages to wetlands are reversible, but it is not always clear how much can be retained through re...

The integration of negative affect, pain and cognitive control in the cingulate cortex

Abstract: It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate — the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor centres responsible for expressing affect and executing goal-directed behaviour. Computational modelling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of the dorsal cingulate's contribution to negative affect and pain.