Institution
University of Wisconsin-Madison
Education•Madison, Wisconsin, United States•
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Gene. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.
Topics: Population, Gene, Context (language use), Health care, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The results show that the hypothalamic IKKbeta/NF-kappaB program is a general neural mechanism for energy imbalance underlying obesity and suggest that suppression of IKK beta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance.
1,198 citations
TL;DR: A certain problem structure that arises frequently in machine learning applications is shown, showing that efficient implementations of accelerated coordinate descent algorithms are possible for problems of this type.
Abstract: Coordinate descent algorithms solve optimization problems by successively performing approximate minimization along coordinate directions or coordinate hyperplanes. They have been used in applications for many years, and their popularity continues to grow because of their usefulness in data analysis, machine learning, and other areas of current interest. This paper describes the fundamentals of the coordinate descent approach, together with variants and extensions and their convergence properties, mostly with reference to convex objectives. We pay particular attention to a certain problem structure that arises frequently in machine learning applications, showing that efficient implementations of accelerated coordinate descent algorithms are possible for problems of this type. We also present some parallel variants and discuss their convergence properties under several models of parallel execution.
1,198 citations
University of Virginia1, Liverpool John Moores University2, Texas Christian University3, University of La Laguna4, Spanish National Research Council5, Johns Hopkins University6, New Mexico State University7, Sternberg Astronomical Institute8, University of Arizona9, Ohio State University10, Pennsylvania State University11, University of Wisconsin-Madison12, Eötvös Loránd University13, University of Toronto14, University of Michigan15, University of Texas at Austin16, Leibniz Institute for Astrophysics Potsdam17, Yale University18, University of Colorado Boulder19, New York University20, Princeton University21, University of Utah22, Goddard Space Flight Center23, Aarhus University24, University of Birmingham25, Harvard University26, Computer Sciences Corporation27, Space Telescope Science Institute28, Paris Diderot University29, INAF30, Max Planck Society31, Space Science Institute32, Pierre-and-Marie-Curie University33, University of Franche-Comté34, Federal University of Rio de Janeiro35, University of Nice Sophia Antipolis36
TL;DR: In this article, the Hungarian National Research, Development and Innovation Office (K-119517) and Hungarian National Science Foundation (KNFI) have proposed a method to detect the presence of asteroids in Earth's magnetic field.
Abstract: National Science Foundation [AST-1109178, AST-1616636]; Gemini Observatory; Spanish Ministry of Economy and Competitiveness [AYA-2011-27754]; NASA [NNX12AE17G]; Hungarian Academy of Sciences; Hungarian NKFI of the Hungarian National Research, Development and Innovation Office [K-119517]; Alfred P. Sloan Foundation; National Science Foundation; U.S. Department of Energy Office of Science
1,193 citations
TL;DR: The effects of CLA appear to be due in part to reduced fat deposition and increased lipolysis in adipocytes, possibly coupled with enhanced fatty acid oxidation in both muscle cells and adipocytes.
Abstract: The effects of conjugated linoleic acid (CLA) on body composition were investigated. ICR mice were fed a control diet containing 5.5% corn oil or a CLA-supplemented diet (5.0% corn oil plus 0.5% CLA). Mice fed CLA-supplemented diet exhibited 57% and 60% lower body fat and 5% and 14% increased lean body mass relative to controls (P < 0.05). Total carnitine palmitoyltransferase activity was increased by dietary CLA supplementation in both fat pad and skeletal muscle; the differences were significant for fat pad of fed mice and skeletal muscle of fasted mice. In cultured 3T3-L1 adipocytes CLA treatment (1 x 10(-4)M) significantly reduced heparin-releasable lipoprotein lipase activity (-66%) and the intracellular concentrations of triacylglyceride (-8%) and glycerol (-15%), but significantly increased free glycerol in the culture medium (+22%) compared to control (P < 0.05). The effects of CLA on body composition appear to be due in part to reduced fat deposition and increased lipolysis in adipocytes, possibly coupled with enhanced fatty acid oxidation in both muscle cells and adipocytes.
1,193 citations
TL;DR: The isolated p95 gene encoding p95, a member of the hMre11/hRad50 double-strand break repair complex, reveals a direct molecular link between DSB repair and cell cycle checkpoint functions in NBS.
1,191 citations
Authors
Showing all 109671 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric S. Lander | 301 | 826 | 525976 |
| Ronald C. Kessler | 274 | 1332 | 328983 |
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| Yi Chen | 217 | 4342 | 293080 |
| David Miller | 203 | 2573 | 204840 |
| Robert M. Califf | 196 | 1561 | 167961 |
| Ronald Klein | 194 | 1305 | 149140 |
| Joan Massagué | 189 | 408 | 149951 |
| Jens K. Nørskov | 184 | 706 | 146151 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| H. S. Chen | 179 | 2401 | 178529 |
| Ramachandran S. Vasan | 172 | 1100 | 138108 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Avshalom Caspi | 170 | 524 | 113583 |
| Jiawei Han | 168 | 1233 | 143427 |