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Institution

University of Wisconsin-Madison

EducationMadison, Wisconsin, United States
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Gene. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.


Papers
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Journal ArticleDOI
15 Feb 2017-Methods
TL;DR: TrackMate is an extensible platform where developers can easily write their own detection, particle linking, visualization or analysis algorithms within the TrackMate environment and is validated for quantitative lifetime analysis of clathrin-mediated endocytosis in plant cells.

2,356 citations

Journal ArticleDOI
TL;DR: In this paper, the authors developed a statistical theory for threshold estimation in the regression context, which is shown to yield asymptotically conservative confidence regions and Monte Carlo simulations are presented to assess the accuracy.
Abstract: .Threshold models have a wide variety of applications in economics. Direct applications include models of separating and multiple equilibria. Other applications include empirical sample splitting when the sample split is based on a continuously-distributed variable such as firm size. In addition, threshold models may be used as a parsimonious strategy for nonparametric function estimation. For example, the threshold autoregressive model .TAR is popular in the nonlinear time series literature. Threshold models also emerge as special cases of more complex statistical frameworks, such as mixture models, switching models, Markov switching models, and smooth transition threshold models. It may be important to understand the statistical properties of threshold models as a preliminary step in the development of statistical tools to handle these more complicated structures. Despite the large number of potential applications, the statistical theory of threshold estimation is undeveloped. It is known that threshold estimates are super-consistent, but a distribution theory useful for testing and inference has yet to be provided. This paper develops a statistical theory for threshold estimation in the regression context. We allow for either cross-section or time series observations. Least squares estimation of the regression parameters is considered. An asymptotic distribution theory . for the regression estimates the threshold and the regression slopes is developed. It is found that the distribution of the threshold estimate is nonstandard. A method to construct asymptotic confidence intervals is developed by inverting the likelihood ratio statistic. It is shown that this yields asymptotically conservative confidence regions. Monte Carlo simulations are presented to assess the accuracy of the asymptotic approximations. The empirical relevance of the theory is illustrated through an application to the multiple . equilibria growth model of Durlauf and Johnson 1995 .

2,353 citations

Journal ArticleDOI
TL;DR: In this article, a focus on the contextually specific ways in which people act out and recognize identities allows a more dynamic approach than the sometimes overly general and static trio of "race, class, and gender".
Abstract: n today's fast changing and interconnected global world, researchers in a variety of areas have come to see identity as an important analytic tool for understanding schools and society. A focus on the contextually specific ways in which people act out and recognize identities allows a more dynamic approach than the sometimes overly general and static trio of "race, class, and gender." However, the term identity has taken on a great many different meanings in the literature. Rather than survey this large literature, I will sketch out but one approach that draws on one consistent strand of that literature. This is not to deny that other, equally useful approaches are possible, based on different selections from the literature.

2,349 citations

Journal ArticleDOI
Eugenia E. Calle1, Clark W. Heath1, R. J. Coates2, Jonathan M. Liff2  +191 moreInstitutions (45)
TL;DR: Of the many factors examined that might affect the relation between breast cancer risk and use of HRT, only a woman's weight and body-mass index had a material effect: the increase in the relative risk of breast cancer diagnosed in women using HRT and associated with long durations of use in current and recent users was greater for women of lower than of higher weight or body- mass index.

2,343 citations

Journal ArticleDOI
05 Nov 1993-Cell
TL;DR: The purification and identification of the factors necessary for the E6-E6-AP-mediated ubiquitination of p53 are reported, and E 6-AP appears to have ubiquitin-protein ligase activity in the absence of E6.

2,342 citations


Authors

Showing all 109671 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Ronald C. Kessler2741332328983
Gordon H. Guyatt2311620228631
Yi Chen2174342293080
David Miller2032573204840
Robert M. Califf1961561167961
Ronald Klein1941305149140
Joan Massagué189408149951
Jens K. Nørskov184706146151
Terrie E. Moffitt182594150609
H. S. Chen1792401178529
Ramachandran S. Vasan1721100138108
Masayuki Yamamoto1711576123028
Avshalom Caspi170524113583
Jiawei Han1681233143427
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023333
20221,391
202110,151
20209,483
20199,278
20188,546