Institution
University of Wisconsin-Madison
Education•Madison, Wisconsin, United States•
About: University of Wisconsin-Madison is a education organization based out in Madison, Wisconsin, United States. It is known for research contribution in the topics: Population & Gene. The organization has 108707 authors who have published 237594 publications receiving 11883575 citations.
Topics: Population, Gene, Context (language use), Health care, Poison control
Papers published on a yearly basis
Papers
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Stony Brook University1, University of California, Berkeley2, Macquarie University3, University of California, Davis4, University of North Carolina at Chapel Hill5, University of Wisconsin-Madison6, University of California, Santa Barbara7, McGill University8, University of Bergen9, University of California, Irvine10, University of Florida11, University of Colorado Boulder12, University of Georgia13
TL;DR: The mounting evidence for the importance of niche conservatism to major topics in ecology and conservation and other areas where it may be important but has generally been overlooked is described.
Abstract: The diversity of life is ultimately generated by evolution, and much attention has focused on the rapid evolution of ecological traits. Yet, the tendency for many ecological traits to instead remain similar over time [niche conservatism (NC)] has many consequences for the fundamental patterns and processes studied in ecology and conservation biology. Here, we describe the mounting evidence for the importance of NC to major topics in ecology (e.g. species richness, ecosystem function) and conservation (e.g. climate change, invasive species). We also review other areas where it may be important but has generally been overlooked, in both ecology (e.g. food webs, disease ecology, mutualistic interactions) and conservation (e.g. habitat modification). We summarize methods for testing for NC, and suggest that a commonly used and advocated method (involving a test for phylogenetic signal) is potentially problematic, and describe alternative approaches. We suggest that considering NC: (1) focuses attention on the within-species processes that cause traits to be conserved over time, (2) emphasizes connections between questions and research areas that are not obviously related (e.g. invasives, global warming, tropical richness), and (3) suggests new areas for research (e.g. why are some clades largely nocturnal? why do related species share diseases?).
1,390 citations
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University of Texas MD Anderson Cancer Center1, Cornell University2, Rutgers University3, Barts Health NHS Trust4, Jagiellonian University5, University of Wisconsin-Madison6, Stanford University7, University of Virginia8, Hofstra University9, University of Manchester10, University of Ulm11, Ludwig Maximilian University of Munich12, Medical University of Warsaw13, University of Southampton14, Oregon Health & Science University15, Ohio State University16
TL;DR: Ibrutinib shows durable single-agent efficacy in relapsed or refractory mantle-cell lymphoma and is enrolled into two groups: patients who had previously received at least 2 cycles of bortezomib therapy and those who had received less than 2 complete cycles.
Abstract: rolled into two groups: those who had previously received at least 2 cycles of bor - tezomib therapy and those who had received less than 2 complete cycles of bortezo - mib or had received no prior bortezomib therapy. The primary end point was the overall response rate. Secondary end points were duration of response, progression- free survival, overall survival, and safety. RESULTS The median age was 68 years, and 86% of patients had intermediate-risk or high-risk mantle-cell lymphoma according to clinical prognostic factors. Patients had received a median of three prior therapies. The most common treatment-related adverse events were mild or moderate diarrhea, fatigue, and nausea. Grade 3 or higher hematologic events were infrequent and included neutropenia (in 16% of patients), thrombocytope - nia (in 11%), and anemia (in 10%). A response rate of 68% (75 patients) was observed, with a complete response rate of 21% and a partial response rate of 47%; prior treat - ment with bortezomib had no effect on the response rate. With an estimated median follow-up of 15.3 months, the estimated median response duration was 17.5 months (95% confidence interval (CI), 15.8 to not reached), the estimated median progression- free survival was 13.9 months (95% CI, 7.0 to not reached), and the median overall survival was not reached. The estimated rate of overall survival was 58% at 18 months. CONCLUSIONS Ibrutinib shows durable single-agent efficacy in relapsed or refractory mantle-cell lymphoma. (Funded by Pharmacyclics and others; ClinicalTrials.gov number, NCT01236391.)
1,389 citations
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TL;DR: A computer program with the code name DYNAFIT was developed for fitting either the initial velocities or the time course of enzyme reactions to an arbitrary molecular mechanism represented symbolically by a set of chemical equations.
1,388 citations
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TL;DR: It is found that stimulation and tradition values relate strongly to the behaviors that express them; hedonism, power, universalism, and self-direction values relate moderately; and security, conformity, achievement, and benevolence values relate only marginally.
Abstract: Three studies address unresolved issues in value-behavior relations. Does the full range of different values relate to common, recurrent behaviors? Which values relate more strongly to behavior than others? Do relations among different values and behaviors exhibit a meaningful overall structure? If so, how to explain this? We find that stimulation and tradition values relate strongly to the behaviors that express them; hedonism, power, universalism, and self-direction values relate moderately; and security, conformity, achievement, and benevolence values relate only marginally. Additional findings suggest that these differences in value-behavior relations may stem from normative pressures to perform certain behaviors. Such findings imply that values motivate behavior, but the relation between values and behaviors is partly obscured by norms. Relations among behaviors, among values, and jointly among values and behavior exhibit a similar structure. The motivational conflicts and congruities postulated by t...
1,388 citations
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TL;DR: Varenicline is an efficacious, safe, and well-tolerated smoking cessation pharmacotherapy and its short-term and long-term efficacy exceeded that of both placebo and bupropion SR.
Abstract: ContextVarenicline, a partial agonist at the α4β2 nicotinic acetylcholine receptor, has the potential to aid smoking cessation by relieving nicotine withdrawal symptoms and reducing the rewarding properties of nicotine.ObjectiveTo determine the efficacy and safety of varenicline for smoking cessation compared with placebo or sustained-release bupropion (bupropion SR).Design, Setting, and ParticipantsA randomized, double-blind, placebo-controlled trial conducted between June 2003 and March 2005 at 14 research centers with a 12-week treatment period and follow-up of smoking status to week 52. Of 1413 adult smokers who volunteered for the study, 1027 were enrolled; 65% of randomized participants completed the study.InterventionVarenicline titrated to 1 mg twice daily (n = 344) or bupropion SR titrated to 150 mg twice daily (n = 342) or placebo (n = 341) for 12 weeks, plus weekly brief smoking cessation counseling.Main Outcome MeasuresContinuous abstinence from smoking during the last 4 weeks of treatment (weeks 9-12; primary end point) and through the follow-up period (weeks 9-24 and 9-52).ResultsDuring the last 4 weeks of treatment (weeks 9-12), 43.9% of participants in the varenicline group were continuously abstinent from smoking compared with 17.6% in the placebo group (odds ratio [OR], 3.85; 95% confidence interval [CI], 2.69-5.50; P<.001) and 29.8% in the bupropion SR group (OR, 1.90; 95% CI, 1.38-2.62; P<.001). For weeks 9 through 24, 29.7% of participants in the varenicline group were continuously abstinent compared with 13.2% in the placebo group (OR, 2.83; 95% CI, 1.91-4.19; P<.001) and 20.2% in the bupropion group (OR, 1.69; 95% CI, 1.19-2.42; P = .003). For weeks 9 through 52, 23% of participants in the varenicline group were continuously abstinent compared with 10.3% in the placebo group (OR, 2.66; 95% CI, 1.72-4.11; P<.001) and 14.6% in the bupropion SR group (OR, 1.77; 95% CI, 1.19-2.63; P = .004). Treatment was discontinued due to adverse events by 10.5% of participants in the varenicline group, 12.6% in the bupropion SR group, and 7.3% in the placebo group. The most common adverse event with varenicline was nausea, which occurred in 101 participants (29.4%).ConclusionsVarenicline is an efficacious, safe, and well-tolerated smoking cessation pharmacotherapy. Varenicline's short-term and long-term efficacy exceeded that of both placebo and bupropion SR.Trial Registrationclinicaltrials.gov Identifier: NCT00143364
1,387 citations
Authors
Showing all 109671 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric S. Lander | 301 | 826 | 525976 |
Ronald C. Kessler | 274 | 1332 | 328983 |
Gordon H. Guyatt | 231 | 1620 | 228631 |
Yi Chen | 217 | 4342 | 293080 |
David Miller | 203 | 2573 | 204840 |
Robert M. Califf | 196 | 1561 | 167961 |
Ronald Klein | 194 | 1305 | 149140 |
Joan Massagué | 189 | 408 | 149951 |
Jens K. Nørskov | 184 | 706 | 146151 |
Terrie E. Moffitt | 182 | 594 | 150609 |
H. S. Chen | 179 | 2401 | 178529 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Avshalom Caspi | 170 | 524 | 113583 |
Jiawei Han | 168 | 1233 | 143427 |