Journal ArticleDOI
Crohn's disease
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TLDR
The epidemiology, immunobiology, amd natural history of Crohn's disease is discussed; new treatment goals and risk stratification of patients are described; and an evidence based rational approach to diagnosis is provided.About:
This article is published in The Lancet.The article was published on 2012-11-03. It has received 1700 citations till now. The article focuses on the topics: Pattern recognition receptor & Immune system.read more
Citations
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Journal ArticleDOI
Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease
William J. Sandborn,Brian G. Feagan,Paul Rutgeerts,Stephen B. Hanauer,Jean-Frederic Colombel,Jean-Frederic Colombel,Bruce E. Sands,Milan Lukas,Richard N. Fedorak,Scott D. Lee,Brian Bressler,I. Fox,Maria Rosario,Serap Sankoh,Jing Xu,Kristin Stephens,Catherine Milch,Asit Parikh +17 more
TL;DR: Vedolizumab-treated patients with active Crohn's disease were more likely than patients receiving placebo to have a remission, but not a CDAI-100 response, at week 6; patients with a response to induction therapy who continued to receive vedolIZumab (rather than switching to placebo) were morelikely to be in remission at week 52.
Journal ArticleDOI
Cytokines in inflammatory bowel disease
TL;DR: The role of cytokines produced by innate and adaptive immune cells, as well as their relevance to the future therapy of IBD are discussed.
Journal ArticleDOI
Recent Advances in Understanding Enteric Pathogenic Escherichia coli
Matthew A. Croxen,Robyn J. Law,Roland Scholz,Kristie M. Keeney,Marta Wlodarska,B. Brett Finlay +5 more
TL;DR: A comprehensive review highlights recent advances in understanding of the intestinal pathotypes of E. coli, which carry an enormous potential to cause disease and continue to present challenges to human health.
Journal ArticleDOI
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Julián Panés,Damián García-Olmo,Gert Van Assche,Jean-Frederic Colombel,Walter Reinisch,Walter Reinisch,Daniel C. Baumgart,Axel Dignass,Maria Nachury,Marc Ferrante,Lili Kazemi-Shirazi,Jean Charles Grimaud,Fernando de la Portilla,Eran Goldin,Marie Paule Richard,Anne Leselbaum,Silvio Danese +16 more
TL;DR: Cx601 is an effective and safe treatment for complex perianal fistulas in patients with Crohn's disease who did not respond to conventional or biological treatments, or both.
Journal ArticleDOI
Chemically induced mouse models of acute and chronic intestinal inflammation
Stefan Wirtz,Vanessa Popp,Markus Kindermann,Katharina Gerlach,Benno Weigmann,Stefan Fichtner-Feigl,Markus F. Neurath +6 more
TL;DR: This protocol update describes an adaptation of the existing protocol that modifies the technique that has been used to generate improved mouse models that better reflect the nature of IBDs in humans.
References
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Journal ArticleDOI
Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo
Daniel R. Clayburgh,Terrence A. Barrett,Yueming Tang,Jon Meddings,Linda J. Van Eldik,D. Martin Watterson,Lane L. Clarke,Randall J. Mrsny,Jerrold R. Turner +8 more
TL;DR: The data show that epithelial MLCK is essential for intestinal barrier dysfunction and that this barrier dysfunction is critical to pathogenesis of diarrheal disease, and indicate that inhibition of epithelialMLCK may be an effective non-immunosuppressive therapy for treatment of immune-mediated intestinal disease.
Journal ArticleDOI
Two-Year Combination Antibiotic Therapy With Clarithromycin, Rifabutin, and Clofazimine for Crohn’s Disease
Warwick Selby,Paul Pavli,Brendan Crotty,Timothy H. Florin,Graham L. Radford-Smith,Peter R. Gibson,Brent Mitchell,William Connell,Robert Read,Michael Merrett,Hooi C. Ee,D. J. Hetzel +11 more
TL;DR: Using combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for up to 2 years did not find evidence of a sustained benefit, and this finding does not support a significant role for Mycobacterium avium subspecies paratuberculosis in the pathogenesis of Crohn's disease in the majority of patients.
Journal ArticleDOI
Inflammatory bowel disease and domestic hygiene in infancy
TL;DR: Crohn's disease was more common in subjects whose first houses had a hot-water tap and ulcerative colitis showed no clear relation to household amenities in infancy, which may explain why the incidence of Crohn’s disease has increased in developed countries over the past 50 years.
Journal ArticleDOI
Acute Gastroenteritis Is Followed by an Increased Risk of Inflammatory Bowel Disease
TL;DR: The results are compatible with the hypothesis that infectious agents causing an episode of infectious gastroenteritis could play a role in the initiation and/or exacerbation of IBD.
Journal ArticleDOI
Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis.
Paula M. Dionisio,Suryakanth R. Gurudu,Jonathan A. Leighton,Grigoris I Leontiadis,David E. Fleischer,Amy K. Hara,Russell I. Heigh,Arthur D. Shiff,Virender K. Sharma +8 more
TL;DR: A meta-analysis demonstrates that CE is superior to SBR, CTE, and C+IL in the evaluation of suspected CD patients and is also a more effective diagnostic tool in established CD patients compared with S BR, Cte, and PE.
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