Journal ArticleDOI
Crohn's disease
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TLDR
The epidemiology, immunobiology, amd natural history of Crohn's disease is discussed; new treatment goals and risk stratification of patients are described; and an evidence based rational approach to diagnosis is provided.About:
This article is published in The Lancet.The article was published on 2012-11-03. It has received 1700 citations till now. The article focuses on the topics: Pattern recognition receptor & Immune system.read more
Citations
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Journal ArticleDOI
The operative risk and natural history after the diagnosis of ileal penetrating Crohn's disease
Peter Bossuyt,Celine Debeuckelaere,Marc Ferrante,Dirk Vanbeckevoort,Thomas Billiet,Albert Wolthuis,Gert Van Assche,André D'Hoore,Severine Vermeire +8 more
TL;DR: The presence of an abscess showed a significant association with the need for surgery and an acceptable postoperative complication rate, and the long-term outcome after surgery was favourable.
Posted ContentDOI
The Effects of Host Taxon, Hybridization, and Environment on the Gut Microbiome of Callithrix Marmosets
Joanna Malukiewicz,Joanna Malukiewicz,Reed A. Cartwright,Jorge Abdala Dergam,Claudia S Igayara,Sharon E Kessler,Sharon E Kessler,Silvia B. Moreira,Leanne T. Nash,Patricia Avello Nicola,Luiz Cezar Machado Pereira,Alcides Pissinati,Carlos R. Ruiz-Miranda,Andrew T. Ozga,Andrew T. Ozga,Christian Roos,Daniel L. Silva,Anne C. Stone,Adriana D. Grativol +18 more
TL;DR: Findings show that carbohydrate metabolism is integral to the composition and function of the wild exudivore gut microbiome, and captivity perturbs the exUDivore Gut microbiome, raising implications for captive host health and endangered exudIVore conservation.
Journal ArticleDOI
Inflammatory bowel disease biomarkers
TL;DR: This review focuses on novel biomarkers that have emerged in recent years that could potentially be used for disease management in IBD, thereby decreasing patient discomfort and morbidity.
Journal ArticleDOI
Organ space infection following ileocolectomy for Crohn's disease: a National Surgical Quality Improvement Project study
TL;DR: Weight loss is a preoperative, potentially modifiable variable associated with OSI in Crohn's patients undergoing ileocolectomy and OSI-associated operative factors which may be noted to identify high-risk patients include extended operating time and open procedures.
Journal ArticleDOI
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
Jerry W. Shay,Noriko Homma,Ruyun Zhou,Muhammad Imran Naseer,Adeel Gulzar Chaudhary,Mohammed Al-Qahtani,Nobutaka Hirokawa,Nobutaka Hirokawa,Maryam Goudarzi,Albert J. Fornace,Saleh S. Baeesa,Deema Hussain,Mohammed Bangash,Fahad Alghamdi,Hans-Juergen Schulten,Angel Carracedo,Ishaq N. Khan,Hanadi Qashqari,Nawal Madkhali,Mohamad Saka,Kulvinder Singh Saini,Awatif A. Jamal,Jaudah Al-Maghrabi,Adel M. Abuzenadah,Adeel G. Chaudhary,Mohammed Al Qahtani,Ghazi A. Damanhouri,Heba Alkhatabi,Anne Goodeve,Laura Crookes,Nikolas Niksic,Nicholas J. Beauchamp,Adel Mohammad Abuzenadah,Jim Vaught,Bruce Budowle,Bruce Budowle,Mourad Assidi,Abdelbaset Buhmeida,Leena Merdad,Sudhir Kumar,Sayaka Miura,Karen Gomez,Mahmood Rasool,Ahmed Rebai,Sajjad Karim,Hend F. Nour Eldin,Heba Abusamra,Elham M. Alhathli,Nada Salem,Mohammed H. Al-Qahtani,Hossam Faheem,Ashok Agarwa,Eberhard Nieschlag,Eberhard Nieschlag,Joachim Wistuba,Oliver S. Damm,Mohd A. Beg,Taha A. Abdel-Meguid,Hisham A. Mosli,Osama S. Bajouh,Serdar Coskun,Muhammad Abu-Elmagd,Ashraf Dallol,Sahar Hakamy,Wejdan Al-Qahtani,Asia Al-Harbi,Shireen Hussain,Burak Ozkosem,Rick DuBois,Safia S. Messaoudi,Maryam T. Dandana,Touhami Mahjoub,Wassim Y. Almawi,S. Abdalla,M. Nabil Al-Aama,Asmaa Elzawahry,Tsuyoshi Takahashi,Sachiyo Mimaki,Eisaku Furukawa,Rie Nakatsuka,Isao Kurosaka,Takahiko Nishigaki,Hiromi Nakamura,Satoshi Serada,Tetsuji Naka,Seiichi Hirota,Tatsuhiro Shibata,Katsuya Tsuchihara,Toshirou Nishida,Mamoru Kato,Sajid Mehmood,Naeem Mahmood Ashraf,Awais Asif,Muhammad Bilal,Malik Siddique Mehmood,Aadil Hussain,Qazi Mohammad Sajid Jamal,Mughees Uddin Siddiqui,Mohammad A. Alzohairy,Mohammad A. Al Karaawi,Taoufik Nedjadi,Heba Al-Khattabi,Adel Al-Ammari,Ahmed Al-Sayyad,Hédia Zitouni,Nozha Raguema,Marwa Ben Ali,Wided Malah,Raja Lfalah,Wassim Y. Almawi,Mohammed Elanbari,Andrey A. Ptitsyn,Sana Mahjoub,Rabeb El Ghali,Bechir Achour,Nidhal Ben Amor,Brahim N’siri,Hamid Morjani,E. Azhar,Vera Chayeb,Vera Chayeb,Maryam Dendena,Khedija Zouari-Limayem,Bassem Refaat,Ahmed M. Ashshi,Sarah Abdullah Batwa,Hazem Ramadan,Amal Awad,Ahmed Ateya,Adel Galal El-Shemi,Adel Galal El-Shemi,Ahmad M. Ashshi,Mohammed Basalamah,Youjin Na,Chae-Ok Yun,Adel Galal El-Shemi,Adel Galal El-Shemi,Osama Adnan Kensara,Amr Abdelfattah,Batol Imran Dheeb,Mohammed M.F. Al-Halbosiy,Rghad Kadhim Al lihabi,Basim Mohammed Khashman,Djouhri Laiche,Chaudhary Adeel,Nedjadi Taoufik,Hani M. Al-Afghani,Hani M. Al-Afghani,Maria Łastowska,Haya H. Al-Balool,Harsh Sheth,Emma Mercer,Jonathan Coxhead,Christopher P.F. Redfern,Heiko Peters,Alastair D. Burt,Mauro Santibanez-Koref,Chris M. Bacon,Louis Chesler,Alistair G. Rust,David J. Adams,Daniel Williamson,Steven C. Clifford,Michael S. Jackson,Mala Singh,Mohmmad Shoab Mansuri,Shahnawaz D. Jadeja,Hima Patel,Yogesh S Marfatia,Rasheedunnisa Begum,Amal M. Mohamed,Alaa K. Kamel,Nivin A. Helmy,Sayda A. Hammad,Hesham F. Kayed,Marwa I. Shehab,Assad El Gerzawy,Maha M. Ead,Ola M. Ead,Mona Mekkawy,Innas Mazen,Mona El-Ruby,S. M. A. Shahid,J. M. Arif,Mohtashim Lohani,Moumni Imen,Chaouch Leila,Ouragini Houyem,Douzi Kais,Chaouachi Dorra Mellouli Fethi,Bejaoui Mohamed,Abbes Salem,Areeg Faggad,Amanuel Tsegai Gebreslasie,Hani Yousif Zaki,Badreldin E. Abdalla,Badreldin E. Abdalla,Maha S Al-Shammari,Rhaya Al-Ali,Nader Al-Balawi,Mansour S Al-Enazi,Ali A Al-Muraikhi,Fadi N Busaleh,Ali S Al-Sahwan,Francis J. Borgio,Abdulazeez Sayyed,Amein K. Al-Ali,Sadananda Acharya,Maha S. Zaki,Hala T. El-Bassyouni,Mohammed F. Elshal,Mohammed Kaleemuddin,Alia M. Aldahlawi,Omar I. Saadah,J. Philip McCoy,Adel E. El-Tarras,Nabil S. Awad,Nabil S. Awad,Abdulla A. Alharthi,Mohamed M. M. Ibrahim,Haneen Alsehli,Abdullah Gari,Mohammed M. Abbas,Roaa Kadam,Mazen M. Gari,Mohmmed H. Alkaff,Mamdooh Gari,Fatima A. Moradi,Omran M. Rashidi,Zuhier Awan,Ibrahim H. Kaya,Olfat Al-Harazi,Dilek Colak,Nabila A. Alkousi,Takis Athanasopoulos,Afnan Omar Bahmaid,Etimad A. Alhwait,Mohammed H. 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King,Monika Stoljarova,Monika Stoljarova,Harrell Gill-King,Muhammad Al-Qatani,Farid Ahmed,Taha Abo Almagd,Muhammad Al-Qahtani,Abdelbaset Buhmaida,Rukhsana Satar,Waseem Ahmad,Nazia Nazam,Mohamad I. Lone,Muhammad Imran Naseer,Mohammad Sarwar Jamal,Syed Kashif Zaidi,Peter Natesan Pushparaj,Mohammad Alam Jafri,Shakeel Ahmed Ansari,Hanan Bashier,Abrar Al Qahtani,Amal M. Nour,Adel M. Abu Zenadah,Muhammed Al Qahtani,Muhammad Faheem,Shiny Mathew,Peter Natesan Pushparaj,Mohammad H. Al-Qahtani,Hani A. Alhadrami,Ibtessam R. Hussein,Rima S Bader,Randa Bassiouni,Maha Alquaiti,Fai Ashgan,Hans Schulten,Mohamed Nabil Alama,Mohammad H. Al Qahtani,Mohammad Iqbal Lone,Nazia Nizam,Muhammed H. Al-Qahtani,Eradah Alshihri,Lina Al-Harbi,Peter Pushparaj Natesan,Fazal Khan,Khalid Sait,Nisreen Anfinan,Lobna S. Mira,Sameera Sogaty,Randa Bassiouni,Abdulrahman M. S. Sibiani,Mohiuddin K. Warsi,Rubi,Kundan Kumar,Ahmad Abu Turab Naqvi,Faizan Ahmad,I. Hassan,Ashraf Ali,Jummanah Jarullah,Abdelbasit Buhmeida,Shahida A. Khan,Ghufrana Abdussami,Maryam Mahfooz,Mohammad Amjad Kamal,Ghazi Al Damanhouri,Bushra Jarullah,Mohammad S. S. Jarullah,Osama S. Bajouh,Abdulah E. A. Mathkoor,Hashim M. A. Alsalmi,Anas M. M. Oun,Ghazi A. Damanhauri,Adeel G. Chudhary,Yousif A. Abutalib,Daniele Merico,Susan Walker,Christian R. Marshall,Mehdi Zarrei,Stephen W. Scherer,Stephen W. Scherer,Stephen W. Scherer,Fai Talal Ashgan,Syed Kashif Zaidi,Mohammed M. Jan,Maryam H. Al-Zahrani,Sahira Lary,Emmanuel Dermitzakis,Abeer A. ALrefai,Abeer A. ALrefai,Mona Mohamed Saleh,Rehab I. Yassien,Mahmmoud Kamel,Rabab M. Habeb,Najlaa Filimban,Nadia Ghannam,Adel Mohammed Abuzenadah,Fehmida Bibi,Sana Akhtar,Esam I. Azhar,Muhammad Yasir,Muhammad I. Nasser,Asif A. Jiman-Fatani,Ali Sawan,Ruaa A. Lahzah,Asho Ali,Syed Asif Hassan,Seyed E. Hasnain,Iftikhar Aslam Tayubi,Hamza A. S. Abujabal,Alaa O. Magrabi,Adel Abuzenada,Taha Abduallah Kumosani,Elie K. Barbour,Elie K. Barbour,Manal M. 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El Sayed,Eman Abdelrazek Hafez,Aisha Elaimi,Randa Ibrahim Bassiouni,Richard F. Wintle,Vikram Gopalakrishna Pillai,Vikram Gopalakrishna Pillai,Sujata Sharma,Punit Kaur,Alagiri Srinivasan,Tej P. Singh,Fatima Al-Adwani,Deema Hussein,Mona Al-Sharif,Saleh S. Baeesa,Taha Abdullah Kumosani,Faisal A. Al-Allaf,Zainularifeen Abduljaleel,Abdullah Alashwal,Mohiuddin M. Taher,Abdellatif Bouazzaoui,Halah Abalkhail,Faisal A. Ba-Hammam,Mohammad Athar,Khalid HussainWali Sait,Naira Ben Mami,Yosr Z. Haffani,Mouna Medhioub,Lamine Hamzaoui,Ameur Cherif,Msadok Azouz,Mohammed Imran Nasser,Shereen A. Turkistany,Lina M. Al-harbi,Jamal S. M. Sabir,Basmah Al-Madoudi,Bayan Al-Aslani,Khulud Al-Harbi,Rwan Al-Jahdali,Hanadi Qudaih,Emad Al Hamzy,Asad Muhammad Ilyas,Youssri M. Ahmed,Alaa Alamandi,Ohoud Subhi,Nadia Bagatian,Adel Al-Johari,Osman Abdel Al-Hamour,Hosam Al-Aradati,Abdulmonem Al-Mutawa,Faisal Al-Mashat,Mohammad Husein Alqahtani,Muhammad Waseem Shah,Saad Al-Masoodi,Emna Khamla,Chaima Jlassi,Ahmed Masmoudi,Lassaad Belbahri,Shadi S. Alkhayyat,Roba Attas,Atlal Abusanad,Mohammed F. Abuzinadah,Habib Bouazzi,Carlos Trujillo,Maha Alotaibi,Rami Nassir,Essam H. Jiffri,Ghulam Md Ashraf,Mohammad Azhar Aziz,Rizwan Ali,Nusaibah Samman,Sathish Periyasamy,Mohammed Aldress,Majed Al Otaibi,Zeyad Al Yousef,Mohamed Boudjelal,Ibrahim AlAbdulkarim,Mohd Suhail,Abid Qureshi,Adil Jamal,Mahmoud Zaki El-Readi,Mahmoud Zaki El-Readi,Safaa Yehia Eid,Safaa Yehia Eid,Michael Wink,Ahmed M. Isa,Lulu Alnuaim,Johara Al-Mutawa,Basim Abu-Rafae,Saleh A. Alasiri,Saleh Binsaleh,Mohamed H. Alqahtani +560 more
TL;DR: The Klinefelter syndrome, a new look to reproductive medicine in the era of genomics, and clinical implementation of pharmacogenomics for colorectal cancer treatment are highlighted.
References
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Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
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Enterotypes of the human gut microbiome
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Journal ArticleDOI
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Seth Rakoff-Nahoum,Justin C. Paglino,Fatima Eslami-Varzaneh,Stephen C. Edberg,Ruslan Medzhitov +4 more
TL;DR: It is shown that commensal bacteria are recognized by TLRs under normal steady-state conditions, and this interaction plays a crucial role in the maintenance of intestinal epithelial homeostasis and protection from injury.
Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.
Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
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