Journal ArticleDOI
Crohn's disease
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TLDR
The epidemiology, immunobiology, amd natural history of Crohn's disease is discussed; new treatment goals and risk stratification of patients are described; and an evidence based rational approach to diagnosis is provided.About:
This article is published in The Lancet.The article was published on 2012-11-03. It has received 1700 citations till now. The article focuses on the topics: Pattern recognition receptor & Immune system.read more
Citations
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GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis
TL;DR: It is demonstrated for the first time that GART expression is up-regulated in patients with active CD and in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced acute colitis model, providing a new potential approach in designing a novel therapy for CD.
Journal ArticleDOI
Monogenic Inflammatory Bowel Disease: It's Never Too Late to Make a Diagnosis.
Iddo Vardi,Irit Chermesh,Lael Werner,Lael Werner,Ortal Barel,Ortal Barel,Tal Freund,Tal Freund,Collin C. McCourt,Yael Fisher,Marina Pinsker,Marina Pinsker,Elisheva Javasky,Elisheva Javasky,Batia Weiss,Batia Weiss,Gideon Rechavi,Gideon Rechavi,David Hagin,David Hagin,Scott B. Snapper,Scott B. Snapper,Raz Somech,Liza Konnikova,Liza Konnikova,Dror S. Shouval,Dror S. Shouval +26 more
TL;DR: This case highlights the importance of advanced genetic studies in patients with a unique phenotype, regardless of their age at presentation, and identifies a novel deleterious c.1455C>A (p.Y485X) mutation in LRBA.
Journal ArticleDOI
Inflammasomes and Colorectal Cancer.
Sanaz Keshavarz Shahbaz,Khadijeh Koushki,Seyed Hassan Ayati,Abigail R. Bland,Evgeny E. Bezsonov,Amirhossein Sahebkar +5 more
TL;DR: In this article, the authors reviewed the role of inflammasomes in colorectal cancer development and showed that inflammmasomes play contradictory roles in the development of inflammation-induced cancers.
Journal ArticleDOI
Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets
TL;DR: Curcumin suppressed INMEC invasion and angiogenesis induced by activated platelets via inhibiting the activation of the PI3K/AKT/mTOR pathway.
Journal ArticleDOI
Tracing the dynamic expression of the Nfκb2 gene during inflammatory processes by in vivo bioluminescence imaging in transgenic mice.
TL;DR: The results suggest that the B6-Tg(Nfκb2-luc)Mlit mice represent a valuable reporter mouse model not only to monitor the expression of p52/p100 in physiological or pathological processes but also to evaluate the effects of various anti-inflammatory drug treatments in vivo.
References
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Journal ArticleDOI
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Seth Rakoff-Nahoum,Justin C. Paglino,Fatima Eslami-Varzaneh,Stephen C. Edberg,Ruslan Medzhitov +4 more
TL;DR: It is shown that commensal bacteria are recognized by TLRs under normal steady-state conditions, and this interaction plays a crucial role in the maintenance of intestinal epithelial homeostasis and protection from injury.
Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.
Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
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