Journal ArticleDOI
Crohn's disease
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TLDR
The epidemiology, immunobiology, amd natural history of Crohn's disease is discussed; new treatment goals and risk stratification of patients are described; and an evidence based rational approach to diagnosis is provided.About:
This article is published in The Lancet.The article was published on 2012-11-03. It has received 1700 citations till now. The article focuses on the topics: Pattern recognition receptor & Immune system.read more
Citations
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Magnetic resonance enterography changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn’s disease: correlation with SES-CD and clinical-biological markers
Luca Pio Stoppino,Nicola Della Valle,Stefania Rizzi,Elsa Cleopazzo,A. Centola,Donatello Iamele,Christos Bristogiannis,G. Stoppino,Roberta Vinci,Luca Macarini +9 more
TL;DR: The MaRIA has a good correlation with SES-CD, a high accuracy for prediction of endoscopic mucosal healing and is a reliable indicator to monitor the use of TNF antagonists in patients with CD.
Journal ArticleDOI
Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial
Bruce E. Sands,Peter M. Irving,T. C. Hoops,James L. Izanec,Long Long Gao,Christopher Gasink,Andrew Greenspan,Matthieu Allez,Silvio Danese,Stephen B. Hanauer,Vipul Jairath,Tanja Kuehbacher,James D. Lewis,Edward V. Loftus,Remo Panaccione,Ellen Scherl,William J. Sandborn,Anita Afzali,L R Aitova,Xavier Aldeguer Manté,István Altorjay,F Argüelles Arias,Alessandro Armuzzi,Monika Augustyn,M. Bafutto,Jesus Barrio,Jakob Begun,Clint E Behrend,G. Bezemer,Guillaume Bonnaud,Marija Branković,Ik Jang Byung,Xavier Calvet Calvo,Karen A. Chachu,Julio Maria Fonseca Chebli,Jae Hee Cheon,Halina Cichoż-Lach,Larry E. Clark,Fraser Cummings,Kunal K Dalal,Nanne K. H. de Boer,Maria de Lourdes Abreu Ferrari,Etienne Desilets,Predrag Dugalic,G. Aaron DuVall,O. V. Fedorishina,Rafał Filip,Cristina Flores,Ronald Fogel,James Fon,Michael S. Frankel,Keith Friedenberg,Walter Fries,V Denisova Galina,Piotr Gietka,Rishi M Goel,Peter Hasselblatt,Hans H Herfarth,László Herszényi,Pieter Hindryckx,Frank Hoentjen,Carmen S Horjus Talabur Horje,Satish Iduru,Robert J. Isfort,Michael P. Jones,D. Kh. Kalimullina,Jeff Katz,Manreet Kaur,Sunil Khurana,Joo Sung Kim,Youngho Yungho Kim,Dariusz Kleczkowski,Slavko Knezevic,Aaron Knoll,Louis Y. Korman,Iskren Kotzev,A.V. Kulyapin,Kang Moon Lee,D. Leemreis,Jaroslaw Leszczyszyn,Jimmy K. Limdi,Jack J. Lissauer,Ewa Małecka-Panas,John Marshall,Emese Mihály,Lukas Milan,Giovanni Monteleone,Aleksandar Nagorni,Danuta Owczarek,Nichole Palekar,Young Soo Park,Sang Hyoung Park,Rogério Serafim Parra,Árpád V. Patai,Kamal V. Patel,Bhaktasharan Patel,A.A. Pershko,Elina Petrova,Guillaume Pineton de Chambrun,C. Randall,Sabino Riestra Menéndez,Timothy L. Ritter,Montserrat Rivero,Xavier Roblin,Rodolfo Rocca,Jacek Romatowski,Grażyna Rydzewska,Simone Saibeni,Bruce Salzberg,H.L. Sarles,John Saunders,Edoardo Savarino,Zuzana Serclova,O. B. Shchukina,Jonathan H. Siegel,Najm M. Soofi,Miles P. Sparrow,D Stokesberry,Daniel R. Suiter,Petar Svorcan,Alexander Tkachev,Nikolay Tsonev,Kristóf Tünde,Jan Ulbrych,Tomas Vanasek,Márta Varga,Severine Vermeire,Raquel Vicente Lidón,Michael L Weiss,Emma Wesley,Nathaniel S. Winstead,Katarzyna Wójcik,Joanna Wypych,Cyrla Zaltman,Zadorova Zdena +134 more
Journal ArticleDOI
Computed Tomography and Magnetic Resonance Enterography in Crohn's Disease: Assessment of Radiologic Criteria and Endpoints for Clinical Practice and Trials
TL;DR: The role of computed tomography enterography and MRE in disease management algorithms in clinical practice is discussed, the currently developed MRE-based scoring systems, their strengths and pitfalls, as well as the role for Mre in clinical trials for Crohn's disease are compared.
Journal ArticleDOI
Fungal infections in patients with inflammatory bowel disease: A systematic review
TL;DR: Despite reports of fungal infections in patients with inflammatory bowel disease, their clinical and microbiological characteristics remain unknown.
Journal ArticleDOI
Isotretinoin and risk of inflammatory bowel disease: a French nationwide study.
Antoine Racine,Anne Cuerq,Anne Bijon,Philippe Ricordeau,Alain Weill,Hubert Allemand,Olivier Chosidow,Marie-Christine Boutron-Ruault,Franck Carbonnel +8 more
TL;DR: In this population-based case–control study in France, isotretinoin use was not associated with increased UC risk but was associated with a decreased CD risk, which provides reassuring data for people using isot retinoin.
References
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Journal ArticleDOI
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Seth Rakoff-Nahoum,Justin C. Paglino,Fatima Eslami-Varzaneh,Stephen C. Edberg,Ruslan Medzhitov +4 more
TL;DR: It is shown that commensal bacteria are recognized by TLRs under normal steady-state conditions, and this interaction plays a crucial role in the maintenance of intestinal epithelial homeostasis and protection from injury.
Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.
Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
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