Journal ArticleDOI
Gut microbiota in neurodegenerative disorders.
TLDR
This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies and reveals that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenersative disorders.About:
This article is published in Journal of Neuroimmunology.The article was published on 2019-03-15. It has received 198 citations till now. The article focuses on the topics: Gut flora.read more
Citations
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Journal ArticleDOI
Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice.
TL;DR: Targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4- and RIG-I-mediated NF-κB signaling pathway and inflammatory responses.
Journal ArticleDOI
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
Qiang Zhu,Jie Jiang,Jie Jiang,Tania F. Gendron,Melissa McAlonis-Downes,Lu-Lin Jiang,Amy Taylor,Sandra Diaz Garcia,Somasish Ghosh Dastidar,Somasish Ghosh Dastidar,María José Cubillas Rodríguez,Patrick King,Yong Jie Zhang,Albert R. La Spada,Albert R. La Spada,Huaxi Xu,Leonard Petrucelli,John Ravits,Sandrine Da Cruz,Sandrine Da Cruz,Clotilde Lagier-Tourenne,Don W. Cleveland +21 more
TL;DR: Low C9ORF72 protein levels support a disease mechanism in ALS/FTD resulting from reduced C9orf72, which can lead to autophagy deficits, synergizing with repeat-dependent gain of toxicity.
Journal ArticleDOI
Gut microbiota-brain axis in depression: The role of neuroinflammation
TL;DR: This review will focus on studies that show the relationship of inflammation with the gut microbiota–brain axis and its relation with MDD.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?
TL;DR: In this article, a review highlights a contribution of the disturbances in the microbiota-gut-brain (MGB) axis to the development of Alzheimer's disease (AD) and highlights the need for new treatment targets and therapies for AD.
Journal ArticleDOI
Gut dysbiosis in Huntington's disease: associations among gut microbiota, cognitive performance and clinical outcomes
Cory I. Wasser,Emily-Clare Mercieca,Geraldine Kong,Anthony J. Hannan,Anthony J. Hannan,Sonja J. McKeown,Yifat Glikmann-Johnston,Julie C. Stout +7 more
TL;DR: The findings suggest an altered gut microbiome in Huntington’s disease gene expansion carriers, which highlight the importance of gut biomarkers and raise interesting questions regarding the role of the gut in Huntington's disease, and whether it may be a potential target for future therapeutic intervention.
References
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Journal ArticleDOI
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Microbial ecology: Human gut microbes associated with obesity
TL;DR: It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet.
Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
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