Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors.
TL;DR: The results suggest that the elevation of S100B and IL‐1 in Alzheimer brain and consequent neurodegenerative events are mediated through cell‐type specific gene‐regulatory events, providing mechanistic insight into connections between glial activation and neuronal dysfunction.
Journal ArticleDOI
Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42).
Fu-Qian He,Bo-Yun Qiu,Xiao-Hui Zhang,Tian-Ke Li,Qin Xie,De-Jun Cui,Xiao-Li Huang,Hua-Tian Gan +7 more
TL;DR: Tetr andrine could significantly ameliorate Aβ(1-42)-induced spatial learning and memory impairment, and the beneficial effect of tetrandrine treatment could be linked, at least in part, to the inhibition of NF-κB activity and the downregulation of expression of IL-1β and TNF-α, suggesting that administration of t Petrandrine may provide a therapeutic approach for AD.
Journal ArticleDOI
Ginger Extract Inhibits β-Amyloid Peptide–Induced Cytokine and Chemokine Expression in Cultured THP-1 Monocytes
Reinhard Grzanna,Phong V. Phan,Anna Polotsky,Lars Lindmark,Carmelita G. Frondoza,Carmelita G. Frondoza +5 more
TL;DR: Experimental evidence that ginger can inhibit the activation of human monocytic THP-1 cells by different proinflammatory stimuli and reduce the expression of a wide range of inflammation-related genes in these microglial-like cells is provided.
Journal ArticleDOI
Neuroprotective Activity of Hypericum perforatum and Its Major Components
Ana Isabel Oliveira,Ana Isabel Oliveira,Cláudia Pinho,Cláudia Pinho,Bruno Sarmento,Bruno Sarmento,Alberto Carlos Pires Dias +6 more
TL;DR: It has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties.
Journal ArticleDOI
Aging enhances classical activation but mitigates alternative activation in the central nervous system.
Daniel C. Lee,Claudia R. Ruiz,Lori Lebson,Maj Linda B. Selenica,Justin Rizer,Jerry B. Hunt,Rahil Rojiani,Patrick Reid,Sidharth Kammath,Kevin Nash,Chad A. Dickey,Marcia N. Gordon,Dave Morgan +12 more
TL;DR: Selective transcripts were induced at all ages by C KT-1, whereas selective gene transcripts induced by CKT-2 decreased with age suggesting an age-related reduction in the IL-4/ IL-13 signaling pathway.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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