Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations
John M. Ringman,Howard Schulman,Chris Becker,Ted Jones,Yuchen Bai,Fred Immermann,Gregory M. Cole,Sophie Sokolow,Karen H. Gylys,Daniel H. Geschwind,Jeffrey L. Cummings,Hong I. Wan +11 more
TL;DR: Much overlap is found in CSF protein changes between individuals with presymptomatic and symptomatic FAD and those with late-onset AD, which is consistent with inflammation and synaptic loss early in Fad and suggest new presymPTomatic biomarkers of potential usefulness in drug development.
Journal ArticleDOI
PPARγ Agonist Curcumin Reduces the Amyloid-β-Stimulated Inflammatory Responses in Primary Astrocytes
Hong-Mei Wang,Yan-Xin Zhao,Shi Zhang,Gui-Dong Liu,Wenyan Kang,Hui-Dong Tang,Jianqing Ding,Sheng-Di Chen +7 more
TL;DR: Results show that curcumin might act as a PPARgamma agonist to inhibit the inflammation in Abeta-treated astrocytes and abolish the anti-inflammatory effect ofCurcumin.
Journal ArticleDOI
Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.
Brittany L. Adler,Mark Yarchoan,Hae Min Hwang,Natalia Louneva,Jeffrey A. Blair,Russell Palm,Mark A. Smith,Hyoung Gon Lee,Steven E. Arnold,Gemma Casadesus +9 more
TL;DR: Results suggest that amylin analogs have neuroprotective properties and might be of therapeutic benefit in AD.
Journal ArticleDOI
Immune profiling of Alzheimer patients
Mariavaleria Pellicanò,Anis Larbi,David Goldeck,Giuseppina Colonna-Romano,Silvio Buffa,Matteo Bulati,Graziella Rubino,Francesco Iemolo,Giuseppina Candore,Calogero Caruso,Evelyna Derhovanessian,Graham Pawelec +11 more
TL;DR: Immunological differences between AD patients and age-matched controls greater than those related to age itself are identified, resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients.
Journal ArticleDOI
Raging the War Against Inflammation With Natural Products.
TL;DR: This review has highlighted the potential lead compounds including berberine, kaurenoic acid, α-cyperone, curcumin, and zedoarondiol for further development with the help of structure–activity relationship (SAR) studies and their current status.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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An endotoxin-induced serum factor that causes necrosis of tumors
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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