Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
Mechanisms underlying inflammation in neurodegeneration.
TL;DR: There is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators in neurodegenerative diseases.
Journal ArticleDOI
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Holly Oakley,Sarah L. Cole,Sreemathi Logan,Erika Maus,Pei Shao,Jeffery Craft,Angela L. Guillozet-Bongaarts,Masuo Ohno,John F. Disterhoft,Linda J. Van Eldik,Robert W. Berry,Robert Vassar +11 more
TL;DR: 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Aβ42-induced neurodegeneration and amyloids plaque formation.
Journal ArticleDOI
Variant of TREM2 associated with the risk of Alzheimer's disease
Thorlakur Jonsson,Hreinn Stefansson,Stacy Steinberg,Ingileif Jonsdottir,Palmi V. Jonsson,Jon Snaedal,Sigurbjorn Bjornsson,Johanna Huttenlocher,Allan I. Levey,James J. Lah,Dan Rujescu,Harald Hampel,Ina Giegling,Ole A. Andreassen,Knut Engedal,Ingun Ulstein,Srdjan Djurovic,Carla A. Ibrahim-Verbaas,Albert Hofman,M. Arfan Ikram,Cornelia M. van Duijn,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +23 more
TL;DR: These findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease and find that carriers of rs75932628-T between the ages of 80 and 100 years without Alzheimer’s disease had poorer cognitive function than noncarriers.
References
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Journal ArticleDOI
Interleukin-1 Expression in Different Plaque Types in Alzheimer's Disease: Significance in Plaque Evolution
TL;DR: The results suggest an important immunological component in the evolution of amyloid-contining plaques in Alzheimer's disease and suggest that IL-1-expressing cells are necessary to intitiate dystrophic neurite formation in diffuse β-amyloid deposits.
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Latent transforming growth factor-β: Structural features and mechanisms of activation
John S. Munger,John G. Harpel,Pierre-Emmanuel Gleizes,Roberta Mazzieri,Irene Nunes,Daniel B. Rifkin +5 more
TL;DR: A general model of activation is proposed in which latent TGF-beta is released from the extracellular matrix by proteases, localized to cell surfaces, and activated by cell-associated plasmin.
Journal ArticleDOI
The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease
TL;DR: There is a small but significant effect of 3- to 6-month treatment with 120 to 240 mg of G. biloba extract on objective measures of cognitive function in patients with Alzheimer disease.
Journal ArticleDOI
Alzheimer's disease: A study of epidemiological aspects
Albert Heyman,William E. Wilkinson,Judith A. Stafford,Michael J. Helms,Alverta H. Sigmon,Tina Weinberg +5 more
TL;DR: There appeared to be no major premorbid demographic or clinical factors associated with this form of dementia, and there was evidence, however, of a genetic factor that was manifested in an excess of dementia and mental retardation in families of patients with Alzheimer's disease.
Journal ArticleDOI
Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
Joachim Bauer,S. Strauss,Ursula Schreiter-Gasser,Ursula Ganter,Petra Schlegel,Irene Witt,Benedikt Yolk,Mathias Berger +7 more
TL;DR: Strong perinuclear α2M immunoreactivity in hippocampal CAI neurons of Alzheimer's disease brains indicates that neuronal cells are the site of βA4‐peptide synthesis in AD brains.
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