Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
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Journal ArticleDOI
Stress, PTSD, and dementia.
TL;DR: More well‐controlled, carefully executed longitudinal studies are needed to confirm the apparent association between stress and dementia, clarify causal relationships, develop reliable antemortem markers, and delineate distinct patterns of risk in subsets of individuals.
Journal ArticleDOI
The probabilistic model of Alzheimer disease: the amyloid hypothesis revised.
Giovanni B. Frisoni,Giovanni B. Frisoni,Daniele Altomare,Daniele Altomare,Dietmar Rudolf Thal,Federica Ribaldi,Rik van der Kant,Rik Ossenkoppele,Kaj Blennow,Jeffrey L. Cummings,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Nilsson,Pierre-Yves Dietrich,Philip Scheltens,Bruno Dubois,Bruno Dubois +16 more
TL;DR: Frisoni et al. as mentioned in this paper proposed a probabilistic model of Alzheimer disease in which three variants of AD (autosomal dominant AD, APOE e4-related sporadic AD and APOE-e4-unrelated AD) feature decreasing penetrance and decreasing weight of the amyloid pathophysiological cascade, and increasing weight of stochastic factors.
Journal ArticleDOI
Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus
Ana M. Espinosa-Oliva,R. M. de Pablos,Ruth F. Villarán,Sandro Argüelles,José L. Venero,Alberto Machado,Josefina Cano +6 more
TL;DR: The hippocampus is insensitive to strong inflammatory stimulus under normal conditions and one of the most severely affected areas in Alzheimer's disease as mentioned in this paper, and the effect of chronic stress for 9 days in the hippocampus unilaterally injected with LPS was analyzed.
Journal ArticleDOI
Novel Panel of Cerebrospinal Fluid Biomarkers for the Prediction of Progression to Alzheimer Dementia in Patients With Mild Cognitive Impairment
Anja Hviid Simonsen,James Mcguire,Oskar Hansson,Henrik Zetterberg,Vladimir N. Podust,Huw Alun Davies,Gunhild Waldemar,Lennart Minthon,Kaj Blennow +8 more
TL;DR: Proteomic profiling of cerebrospinal fluid provided a novel panel of 17 potential biomarkers for prediction of MCI progression to AD and the 5 identified biomarkers are relevant to the pathogenesis of AD and could help gain an understanding of the molecular pathways in which they may function.
Journal ArticleDOI
Can oral infection be a risk factor for Alzheimer's disease?
TL;DR: Oral infection is addressed as the plausible etiology of late-onset AD (LOAD) and periodontitis constitutes a peripheral oral infection that can provide the brain with intact bacteria and virulence factors and inflammatory mediators due to daily, transient bacteremias.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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