Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
Mechanisms underlying inflammation in neurodegeneration.
TL;DR: There is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators in neurodegenerative diseases.
Journal ArticleDOI
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Holly Oakley,Sarah L. Cole,Sreemathi Logan,Erika Maus,Pei Shao,Jeffery Craft,Angela L. Guillozet-Bongaarts,Masuo Ohno,John F. Disterhoft,Linda J. Van Eldik,Robert W. Berry,Robert Vassar +11 more
TL;DR: 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Aβ42-induced neurodegeneration and amyloids plaque formation.
Journal ArticleDOI
Variant of TREM2 associated with the risk of Alzheimer's disease
Thorlakur Jonsson,Hreinn Stefansson,Stacy Steinberg,Ingileif Jonsdottir,Palmi V. Jonsson,Jon Snaedal,Sigurbjorn Bjornsson,Johanna Huttenlocher,Allan I. Levey,James J. Lah,Dan Rujescu,Harald Hampel,Ina Giegling,Ole A. Andreassen,Knut Engedal,Ingun Ulstein,Srdjan Djurovic,Carla A. Ibrahim-Verbaas,Albert Hofman,M. Arfan Ikram,Cornelia M. van Duijn,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +23 more
TL;DR: These findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease and find that carriers of rs75932628-T between the ages of 80 and 100 years without Alzheimer’s disease had poorer cognitive function than noncarriers.
References
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Journal ArticleDOI
Rodent models of Alzheimer's disease: Rat aβ infusion approaches to amyloid deposits
Sally A. Frautschy,Fusheng Yang,Fusheng Yang,Leticia Calderón,Leticia Calderón,Greg M. Cole,Greg M. Cole +6 more
TL;DR: A beta infusion models will be a useful complement to transgenic approaches to Alzheimer's pathology by allowing one to introduce A beta and other plaque-associated factors without overexpression of potentially confounding APP domains.
Journal ArticleDOI
Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex
TL;DR: Results indicate that TGF-β1 may be induced by IL-1 in all glial cells of the frontal cortex, by both autocrine and paracrine mechanisms.
Journal ArticleDOI
Brain Uptake of Circulating Apolipoproteins J and E Complexed to Alzheimer′s Amyloid β
Berislav V. Zlokovic,C. L. Martel,J. B. Mackic,E. Matsubara,Thomas Wisniewski,J G McComb,B. Frangione,Jorge Ghiso +7 more
TL;DR: It is concluded that sA beta 1-40 binding to apo J and apo E results in significant (> 100-fold) difference in brain uptake of their respective complexes, and it is hypothesize that in normal brain apoJ facilitates sAbeta transport.
Journal Article
Glucocorticoids induce apoptosis in human monocytes: potential role of IL-1 beta.
Michael Schmidt,Hans-Gerd Pauels,Norbert Lügering,Andreas Lügering,Wolfram Domschke,Torsten Kucharzik +5 more
TL;DR: This is the first study to demonstrate induction of apoptosis by GC in human monocytes, and it is conceivable that GC exert their anti-inflammatory capacity in various diseases, at least in part, by the inductionof apoptosis in monocytes.
Journal ArticleDOI
Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.
S L Wagner,James W. Geddes,Carl W. Cotman,Alice L. Lau,David Gurwitz,Paul J. Isackson,Dennis D. Cunningham +6 more
TL;DR: It is shown that human brain contains PN-1 and that Pn-1 activity in brains of individuals with Alzheimer disease (AD) was only 14% of control values, and results suggest that the decreases in P nxin activity and free P nXin protein are due to formation of PN -1-protease complexes.
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