Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Inflammation and depression: a causal or coincidental link to the pathophysiology?
TL;DR: The preliminary clinical evidence that some non-steroidal anti-inflammatory drugs, such as the cyclooxygenase 2 inhibitor celecoxib, can enhance the response to standard antidepressant treatment is considered and a critical assessment made of the possible limitations of such an approach to novel antidepressant development is made.
Journal ArticleDOI
Neuroglia in neurodegeneration.
TL;DR: The complex of recently acquired knowledge allows us to regard the neurodegenerative diseases as primarily gliodegenerative processes, in which glial cells determine the progression and outcome of neuropathological process.
Journal ArticleDOI
Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
Jennifer L. Furman,Diana M. Sama,John C. Gant,Tina L. Beckett,M. Paul Murphy,Adam D. Bachstetter,Linda J. Van Eldik,Christopher M. Norris +7 more
TL;DR: A deleterious role for activated astrocytes in AD is confirmed and the groundwork for exploration of other novelAstrocyte-targeted therapeutics in an intact animal model of AD is laid for exploration.
Journal ArticleDOI
Microglia actions in Alzheimer’s disease
TL;DR: Current evidence suggests that microglia lose their intrinsic beneficial function during the course of AD and may even acquire a “toxic” phenotype over time, but Aβ may also simply not be an appropriate trigger to induce phagocytosis and degradation by microglIA in vivo.
Journal ArticleDOI
Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
Amanda L. Wright,Raphael Zinn,Raphael Zinn,Barbara Hohensinn,Barbara Hohensinn,Lyndsey M. Konen,Sarah B. Beynon,Richard P. Tan,Ian A. Clark,Andrea Abdipranoto,Bryce Vissel,Bryce Vissel +11 more
TL;DR: The possibility that plaque load may not be the best marker for early AD is raised and it is suggested that activated microglia could be a valuable marker to track disease progression.
References
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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