Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
Nilay V. Patel,Marcia N. Gordon,Karen E. Connor,Robert A. Good,Robert W. Engelman,Jerimiah E. Mason,David G. Morgan,Todd E. Morgan,Caleb E. Finch +8 more
TL;DR: The influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression.
Journal ArticleDOI
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.
Sarah L. DeVos,Rebecca L. Miller,Kathleen M. Schoch,Brandon B. Holmes,Carey S. Kebodeaux,Amy J. Wegener,Guo Chen,Tao Shen,Hien Tran,Brandon S. Nichols,Tom A. Zanardi,Holly B. Kordasiewicz,Eric E. Swayze,C. Frank Bennett,Marc I. Diamond,Timothy M. Miller +15 more
TL;DR: Data from a mouse model of tauopathy and antisense oligonucleotides that reduce tau prevent neuronal loss and reverse tau deposition and seeding and support investigation of a tau-lowering therapy in human patients who have t Tau-positive inclusions even after pathological t Tau deposition has begun.
Journal ArticleDOI
Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy.
TL;DR: Recent evidence indicates that microglia can be stimulated to assume an antiinflammatory state rather than a proinflammatory state which may have therapeutic potential, and one example is hydrogen sulfide which appears to be an endogenous antiinflammatory agent.
Journal ArticleDOI
Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism
Ke-Jie Yin,John R. Cirrito,Ping Yan,Xiaoyan Hu,Qingli Xiao,Xiaoou Pan,Randall J. Bateman,Haowei Song,Fong-Fu Hsu,John Turk,Jan Xu,Chung Y. Hsu,Jason C. Mills,David M. Holtzman,Jin-Moo Lee +14 more
TL;DR: Results suggest that matrix metalloproteinases (MMPs) may contribute to extracellular brain Aβ clearance by promoting Aβ catabolism.
Journal ArticleDOI
Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.
TL;DR: The data obtained using validated methodology in a well-characterized, presenile cohort reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
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TGF-beta signal transduction.
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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