Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
Mechanisms underlying inflammation in neurodegeneration.
TL;DR: There is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators in neurodegenerative diseases.
Journal ArticleDOI
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Holly Oakley,Sarah L. Cole,Sreemathi Logan,Erika Maus,Pei Shao,Jeffery Craft,Angela L. Guillozet-Bongaarts,Masuo Ohno,John F. Disterhoft,Linda J. Van Eldik,Robert W. Berry,Robert Vassar +11 more
TL;DR: 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Aβ42-induced neurodegeneration and amyloids plaque formation.
Journal ArticleDOI
Variant of TREM2 associated with the risk of Alzheimer's disease
Thorlakur Jonsson,Hreinn Stefansson,Stacy Steinberg,Ingileif Jonsdottir,Palmi V. Jonsson,Jon Snaedal,Sigurbjorn Bjornsson,Johanna Huttenlocher,Allan I. Levey,James J. Lah,Dan Rujescu,Harald Hampel,Ina Giegling,Ole A. Andreassen,Knut Engedal,Ingun Ulstein,Srdjan Djurovic,Carla A. Ibrahim-Verbaas,Albert Hofman,M. Arfan Ikram,Cornelia M. van Duijn,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +23 more
TL;DR: These findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease and find that carriers of rs75932628-T between the ages of 80 and 100 years without Alzheimer’s disease had poorer cognitive function than noncarriers.
References
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Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction
Jeffrey N. Keller,Mark S. Kindy,Fredrick W. Holtsberg,Daret K. St. Clair,Hsiu-Chuan Yen,Arriane Germeyer,Sheldon M. Steiner,Annadora J. Bruce-Keller,James B. Hutchins,Mark P. Mattson +9 more
TL;DR: The data suggest that mitochondrial superoxide accumulation and consequent peroxynitrite production and mitochondrial dysfunction play pivotal roles in neuronal apoptosis induced by diverse insults in cell culture and in vivo.
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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.
Marisol Corral-Debrinski,Terzah M. Horton,Marie T. Lott,John M. Shoffner,M F Beal,Douglas C. Wallace +5 more
TL;DR: Changes in the accumulation of the common 4977 nucleotide pair (np) deletion in the cortex, putamen and cerebellum suggest that somatic mtDNA deletions might contribute to the neurological impairment often associated with ageing.
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Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
TL;DR: The results suggest that microglial activation in AD may be secondary to neurodegeneration and that, once activated, microglia may participate in a local inflammatory cascade that promotes tissue damage and contributes to amyloid formation.
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Interleukin 1 of the central nervous system is produced by ameboid microglia.
TL;DR: It is proposed that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.
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MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease.
TL;DR: The contention that MR-based HF volumetric measurements are accurate in differentiating DAT patients from cognitively normal elderly individuals may be a useful adjunct in making the clinical diagnosis of DAT.
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