Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF
Roman Fischer,Olaf Maier +1 more
TL;DR: The dual role of TNF in promoting neurodegeneration and tissue regeneration via its two receptors is discussed, since stimulation via its second receptor, TNFR2, is neuroprotective and promotes tissue regeneration.
Journal ArticleDOI
Inflammation, autotoxicity and Alzheimer disease
TL;DR: In this paper, the effects of inflammatory stimulators in Alzheimer's disease (AD) have been investigated and some theoretical opportunities are suggested, based on intervention in the action of the above mentioned mediators.
Journal ArticleDOI
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.
Paul Edison,Hilary Archer,Alexander Gerhard,Alexander Gerhard,Rainer Hinz,Rainer Hinz,Nicola Pavese,Federico Turkheimer,Alexander Hammers,Yen F. Tai,Nick C. Fox,A. M. Kennedy,Martin N. Rossor,Martin N. Rossor,David J. Brooks,David J. Brooks +15 more
TL;DR: The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage and the localisation of these increases to association areas is confirmed.
Journal ArticleDOI
A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease
TL;DR: A study of curcumin in patients with AD is performed to gather information on the bioavailability, safety and tolerability of this promising agent in the treatment and/or prevention of AD.
Journal ArticleDOI
Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease
Qiao Yan,Jianhua Zhang,Hantao Liu,Safura Babu-Khan,Robert Vassar,Anja Leona Biere,Martin Citron,Gary E. Landreth +7 more
TL;DR: Data show that chronic NSAID treatment can reduce brain Aβ levels, amyloid plaque burden, and microglial activation in an animal model of Alzheimer's disease.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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