Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
Andrew G. Horti,Yongjun Gao,Hayden T. Ravert,Paige Finley,Heather Valentine,Dean F. Wong,Christopher J. Endres,Alena Savonenko,Robert F. Dannals +8 more
TL;DR: The radiosynthesis of [11C]A-836339 via its desmethyl precursor as a candidate radioligand for imaging CB2 receptors with positron-emission tomography (PET) establishes a proof of principle thatCB2 receptors binding in the neuro inflammation and related disorders can be measured in vivo.
Journal ArticleDOI
Salvia miltiorrhiza: A source for anti-Alzheimer's disease drugs.
TL;DR: The properties of S. miltiorrhiza indicate their therapeutic potential in AD via multiple mechanisms, including anti-amyloid-β, antioxidant, anti-apoptosis, acetylcholinesterase inhibition, and anti- inflammation.
Journal ArticleDOI
In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA.
Ivonne Suridjan,Bruce G. Pollock,Nicolaas Paul L.G. Verhoeff,Nicolaas Paul L.G. Verhoeff,Aristotle N. Voineskos,T Chow,Pablo Rusjan,Nancy J. Lobaugh,Nancy J. Lobaugh,Sylvain Houle,Sylvain Houle,Benoit H. Mulsant,Romina Mizrahi,Romina Mizrahi +13 more
TL;DR: The results suggest that neuroinflammation is associated with some cognitive deficits in patients with Alzheimer’s disease and can be detected in AD patients throughout the brain grey and white matter by using [18F]-FEPPA PET.
Book ChapterDOI
Interleukins, Inflammation, and Mechanisms of Alzheimer's Disease
TL;DR: Inflammatory pathways involving interleukin and cytokine signaling might suggest potential targets for intervention and influence the development of novel therapies to circumvent synaptic and neuronal dysfunction ultimately leading to AD neurodegeneration.
Journal ArticleDOI
Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
Koichi Kawahara,Michita Suenobu,Akira Yoshida,Kiyohiro Koga,Atsushi Hyodo,Hideyuki Ohtsuka,Akihiko Kuniyasu,Nobuaki Tamamaki,Yukihiko Sugimoto,Hitoshi Nakayama +9 more
TL;DR: A unique mechanism of IL-4/IL-13-induced clearance of Aβ may provide an additional strategy to prevent and/or cure Alzheimer's disease at early stage.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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An endotoxin-induced serum factor that causes necrosis of tumors
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Journal ArticleDOI
Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
Journal ArticleDOI
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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