Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis–mass spectrometry
Raúl González-Domínguez,Antonia García,Tamara García-Barrera,Coral Barbas,José Luis Gómez-Ariza +4 more
TL;DR: A metabolomic approach based on ultrafiltration and analysis by CE‐MS has been used to obtain representative fingerprints of polar metabolites from serum samples in order to distinguish between patients with Alzheimer's disease, mild cognitive impairment, and healthy controls.
Journal ArticleDOI
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
Sara L. Montgomery,Michael A. Mastrangelo,Diala Habib,Wade C. Narrow,Sara A. Knowlden,Terry W. Wright,William J. Bowers +6 more
TL;DR: It is demonstrated that globally ablated TNF receptor signaling exacerbates pathogenesis and argues against long-term use of pan-anti-TNF-α inhibitors for the treatment of AD.
Journal ArticleDOI
Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease.
Stephen W. Scheff,Douglas A. Price,Mubeen A. Ansari,Kelly N. Roberts,Frederick A. Schmitt,Milos D. Ikonomovic,Elliott J. Mufson +6 more
TL;DR: The idea that the PostC synaptic function is affected during the prodromal stage of the disease and may underlie some of the early clinical sequelae associated with AD is supported.
Journal ArticleDOI
Periodontitis and Alzheimer's Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation.
Francisco Bruno Teixeira,Miki Taketomi Saito,Filipe C. Matheus,Rui Daniel Prediger,Elizabeth Sumi Yamada,Cristiane Socorro Ferraz Maia,Rafael Rodrigues Lima +6 more
TL;DR: The inflammatory aspects of periodontitis are discussed, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.
Journal ArticleDOI
Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice.
Eun-Bum Kang,Insu Kwon,Jung-Hoon Koo,Eung-Joon Kim,Chul-Hyun Kim,Jin Lee,Choon-Ho Yang,Youngil Lee,In-Ho Cho,Joon-Yong Cho +9 more
TL;DR: T treadmill exercise prevented PS2 mutation-induced memory impairment and reduced Aβ-42 deposition through the inhibition of β-secretase and its product, C-99 in cortex and/or hippocampus of aged PS2 mutant mice and showed that TE suppressed the activation of UPR signaling pathways as well as inhibited the apoptotic pathways of the UPR and inflammatory response following A β-induced ER stress.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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