Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Immunology and immunotherapy of Alzheimer's disease
Howard L. Weiner,Dan Frenkel +1 more
TL;DR: Clinical trials of active amyloid-β vaccination of patients with Alzheimer's disease were discontinued after some patients developed meningoencephalitis, and new immunotherapies using humoral and cell-based approaches are currently being investigated for the treatment and prevention of Alzheimer's Disease.
Journal ArticleDOI
Vascular risk factors, cognitve decline, and dementia
Emmanuelle Duron,Olivier Hanon +1 more
TL;DR: Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed.
Journal ArticleDOI
Microglia and Alzheimer's disease pathogenesis.
TL;DR: A comprehensive and critical look at the overall evidence supporting the neuroinflammation hypothesis and points out some weaknesses is taken, and evidence for an alternative theory, the microglial dysfunction hypothesis, is reviewed, which offers a different perspective on the identity of activated microglia and their role in AD pathogenesis.
Journal ArticleDOI
Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
Alon Monsonego,Victor Zota,Arnon Karni,Jeffery I. Krieger,Amit Bar-Or,Gal Bitan,Andrew E. Budson,Reisa A. Sperling,Dennis J. Selkoe,Howard L. Weiner +9 more
TL;DR: The occurrence of intrinsic T cell reactivity to the self-antigen Abeta in humans has implications for the design of Abeta vaccines, may itself be linked to AD susceptibility and course, and appears to be associated with the aging process.
Journal ArticleDOI
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics
Leslie M. Shaw,Magdalena Korecka,Christopher M. Clark,Virginia M.-Y. Lee,John Q. Trojanowski +4 more
TL;DR: Progress in the development and validation of biomarkers to improve the diagnosis and treatment of Alzheimer's disease and related disorders is focused on.
References
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Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Journal ArticleDOI
TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
Journal ArticleDOI
Chemokines — Chemotactic Cytokines That Mediate Inflammation
TL;DR: This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
Journal ArticleDOI
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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