Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
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Journal ArticleDOI
Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders.
Yu Chang Chen,Jui Sheng Wu,Hsin Da Tsai,Chien Yu Huang,Jin Jer Chen,Grace Y. Sun,Teng-Nan Lin +6 more
TL;DR: Current knowledge on mechanisms underlying the beneficial effect of PPAR-γ in different neurodegenerative diseases are reviewed, and it is concluded that PPar-γ agonists represent a novel class of drugs for treating neuroinflammatory diseases.
Journal ArticleDOI
Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease.
Mayara Chaves Faria,Gisele Santos Gonçalves,Natalia Pessoa Rocha,Edgar Nunes de Moraes,Edgar Nunes de Moraes,Maria Aparecida Camargos Bicalho,Maria Aparecida Camargos Bicalho,Marco Túlio Gualberto Cintra,Jonas Jardim de Paula,Luís Felipe José Ravic de Miranda,Alessandro C. S. Ferreira,Antônio Lúcio Teixeira,Antônio Lúcio Teixeira,Karina Braga Gomes,Maria das Graças Carvalho,Lirlândia P. Sousa +15 more
TL;DR: The increase in BDNF levels might reflect a compensatory mechanism against early neurodegeneration and seems to be related to inflammation, and sTNFR1 appears to mark not only the inflammatory state but also differentiates between MCI and AD, which may be an additional tool for differentiating degrees of cognitive impairment.
Journal ArticleDOI
Statins--a cure-all for the brain?
TL;DR: Animal studies and observational clinical studies have indicated that statins might also be effective in treating certain neurological diseases — in particular, multiple sclerosis, Alzheimer's disease and ischaemic stroke; however, results from ongoing prospective, randomized clinical trials are not available.
Journal ArticleDOI
Microglial transplantation increases amyloid-β clearance in Alzheimer model rats
Kazuyuki Takata,Yoshihisa Kitamura,Daijiro Yanagisawa,Shigehiro Morikawa,Masahito Morita,Masahito Morita,Toshiro Inubushi,Daiju Tsuchiya,Saori Chishiro,Mana Saeki,Takashi Taniguchi,Shun Shimohama,Ikuo Tooyama +12 more
TL;DR: The transplanted rat microglia into the rat lateral ventricle just after intra‐hippocampal Aβ injection, and the contribution of exogenousmicroglia to Aβ clearance were investigated, suggesting the possible usefulness of exogeneous microglias to the therapeutic approach in AD.
Journal ArticleDOI
Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
Rik Ossenkoppele,W.M. van der Flier,Marissa D. Zwan,Sofie F. Adriaanse,Ronald Boellaard,Albert D. Windhorst,Frederik Barkhof,Adriaan A. Lammertsma,Philip Scheltens,B.N.M. van Berckel +9 more
TL;DR: Findings suggest that APOE genotype has a differential effect on the distribution of amyloid plaques and glucose metabolism in the same Alzheimer disease dementia patients, which may have important implications for emerging therapies that aim to directly intervene in the disease process.
References
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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