Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
Citations
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Journal ArticleDOI
Local neuroinflammation and the progression of Alzheimer’s disease
TL;DR: Much epidemiological and limited clinical evidence suggests that nonsteroidal anti-inflammatory drugs may impede the onset and slow the progression of Alzheimer’s disease, but these drugs strike at the periphery of the inflammatory reaction.
Journal ArticleDOI
Parallel findings in age-related macular degeneration and Alzheimer's disease.
TL;DR: Recent findings on the shared characteristics and perspectives between AMD and AD are summarized, beginning with the mechanism of Aβ deposition and including a discussion of A β-targeted therapeutic approaches for both AD and AMD.
Journal ArticleDOI
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Symen Ligthart,Ahmad Vaez,Urmo Võsa,Maria G. Stathopoulou,P. De Vries,Bram P. Prins,P. J. van der Most,Toshiko Tanaka,Elnaz Naderi,Lynda M. Rose,Ying Wu,Robert Karlsson,Maja Barbalić,Honghuang Lin,René Pool,Gu Zhu,Aurélien Macé,C Sidore,Stella Trompet,Massimo Mangino,Maria Sabater-Lleal,John P. Kemp,Ali Abbasi,Tim Kacprowski,Niek Verweij,Albert V. Smith,Tao Huang,Carola Marzi,Mary F. Feitosa,Kurt Lohman,Marcus E. Kleber,Yuri Milaneschi,Christine M. Mueller,M Huq,Efthymia Vlachopoulou,Lyytikäinen L-P.,Christopher Oldmeadow,Joris Deelen,Markus Perola,Jing Hua Zhao,Bjarke Feenstra,Marzyeh Amini,Jari Lahti,Katharina E. Schraut,Myriam Fornage,Bhoom Suktitipat,Chen W-M.,Xiaohui Li,Teresa Nutile,Giovanni Malerba,Jian'an Luan,Tom Bak,Nicholas J. Schork,Elisabeth Thiering,Anubha Mahajan,Riccardo E. Marioni,Evelin Mihailov,Joel Eriksson,Ayse Bilge Ozel,Weihua Zhang,Maria Nethander,Cheng Y-C.,Stella Aslibekyan,Wei Ang,Ilaria Gandin,Loic Yengo,Laura Portas,Charles Kooperberg,Edith Hofer,Kumar B. Rajan,Claudia Schurmann,W. den Hollander,Tarunveer S. Ahluwalia,Jing Zhao,Draisma Hhm.,Ian Ford,Nicholas J. Timpson,Alexander Teumer,Hongyan Huang,Simone Wahl,Yongmei Liu,Jinyan Huang,Uh H-W.,Frank Geller,Peter K. Joshi,Lisa R. Yanek,Elisabetta Trabetti,Benjamin Lehne,Diego Vozzi,M Verbanck,Ginevra Biino,Yasaman Saba,Ingrid Meulenbelt,Jeffery R. O'Connell,Markku Laakso,Franco Giulianini,Magnusson Pke.,Christie M. Ballantyne,J-J Hottenga,Grant W. Montgomery,Fernando Rivadineira,Rico Rueedi,Maristella Steri,Herzig K-H.,David J. Stott,Cristina Menni,Mattias Frånberg,B. St Pourcain,Stephan B. Felix,Tune H. Pers,Bakker Sjl.,Peter Kraft,Annette Peters,Dhananjay Vaidya,Graciela Delgado,Jan H. Smit,V Großmann,Juha Sinisalo,Ilkka Seppälä,Stephen R. Williams,Elizabeth G. Holliday,Matthijs Moed,Claudia Langenberg,Katri Räikkönen,Jun Ding,Harry Campbell,Michèle M. Sale,Chen Y-Di.,Chen Y-Di.,Alan James,Daniela Ruggiero,Nicole Soranzo,Catharina A. Hartman,Erin N. Smith,Gerald S. Berenson,Christian Fuchsberger,Dena G. Hernandez,Tiesler Cmt.,Vilmantas Giedraitis,D C Liewald,Krista Fischer,Dan Mellström,Anders Larsson,Yajuan Wang,William R. Scott,Mattias Lorentzon,John Beilby,Kathleen A. Ryan,Craig E. Pennell,Dragana Vuckovic,Beverley Balkau,Maria Pina Concas,Reinhold Schmidt,C. F. Mendes de Leon,C. F. Mendes de Leon,Erwin P. Bottinger,Margreet Kloppenburg,Lavinia Paternoster,Michael Boehnke,Arthur W. Musk,Gonneke Willemsen,David M. Evans,Madden Paf.,Mika Kähönen,Zoltán Kutalik,Magdalena Zoledziewska,Ville Karhunen,Stephen B. Kritchevsky,Naveed Sattar,Genevieve Lachance,Robert Clarke,T.B. Harris,Olli T. Raitakari,John Attia,D. van Heemst,Eero Kajantie,Rossella Sorice,Giovanni Gambaro,Robert A. Scott,Andrew A. Hicks,Luigi Ferrucci,M. Standl,Cecilia M. Lindgren,John M. Starr,Magnus Karlsson,Lars Lind,Jun Li,John C. Chambers,Trevor A. Mori,de Geus Ejcn.,A. C. Heath,Nicholas G. Martin,Juha Auvinen,Brendan M. Buckley,de Craen Ajm.,M. Waldenberger,Konstantin Strauch,Thomas Meitinger,R. J. Scott,Mark McEvoy,Marian Beekman,Cristina Bombieri,Paul M. Ridker,Karen L. Mohlke,Nancy L. Pedersen,A C Morrison,Dorret I. Boomsma,John Whitfield,David P. Strachan,Albert Hofman,Peter Vollenweider,Francesco Cucca,Jarvelin M-R.,Joop Jukema,Tim D. Spector,Anders Hamsten,Tanja Zeller,André G. Uitterlinden,Matthias Nauck,Vilmundur Gudnason,Lu Qi,H Grallert,Ingrid B. Borecki,Jerome I. Rotter,W. März,Philipp S. Wild,Lokki M-L.,Michael Boyle,Veikko Salomaa,Mads Melbye,Johan G. Eriksson,James F. Wilson,Penninx Bwjh.,Diane M. Becker,B. B. Worrall,Greg Gibson,Ronald M. Krauss,Marina Ciullo,Gianluigi Zaza,Nicholas J. Wareham,Albertine J. Oldehinkel,Lyle J. Palmer,Sarah S. Murray,Peter P. Pramstaller,Stefania Bandinelli,Joachim Heinrich,Erik Ingelsson,Ian J. Deary,Reedik Mägi,Liesbeth Vandenput,P. van der Harst,Karl C. Desch,Jaspal S. Kooner,Claes Ohlsson,Caroline Hayward,Terho Lehtimäki,Alan R. Shuldiner,Donna K. Arnett,Lawrie J. Beilin,Antonietta Robino,Philippe Froguel,Mario Pirastu,T. Jess,Wolfgang Koenig,Loos Rjf.,Denis A. Evans,Helena Schmidt,George Davey Smith,P E Slagboom,Gudny Eiriksdottir,Andrew P. Morris,Bruce M. Psaty,Russel Tracy,Ilja M. Nolte,Eric Boerwinkle,Sophie Visvikis-Siest,Alexander P. Reiner,Myron D. Gross,J. C. Bis,Lude Franke,Oscar H. Franco,E J Benjamin,Daniel I. Chasman,Josée Dupuis,Harold Snieder,Abbas Dehghan,Behrooz Z. Alizadeh +286 more
TL;DR: In this article, the authors performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals.
Journal ArticleDOI
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration.
Edward L Tobinick,Hyman Gross +1 more
TL;DR: Rapid cognitive improvement following perispinal etanercept may be related to amelioration of the effects of excess TNF-alpha on synaptic mechanisms in Alzheimer's disease and provides a promising area for additional investigation and therapeutic intervention.
Journal ArticleDOI
The role of astrocytes in amyloid production and Alzheimer's disease
Georgia R. Frost,Yue-Ming Li +1 more
TL;DR: Mounting evidence suggests that astrocytes may play an additional role in AD by secreting significant quantities of Aβ and contributing to overall amyloid burden in the brain.
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