Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TLDR
By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.About:
This article is published in Neurobiology of Aging.The article was published on 2000-05-01. It has received 4319 citations till now. The article focuses on the topics: Alzheimer's disease & Neuroinflammation.read more
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Journal ArticleDOI
Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer’s disease
Yosef Koronyo,Brenda C. Salumbides,Julia Sheyn,Lindsey Pelissier,Songlin Li,Vladimir A. Ljubimov,Michelle Moyseyev,David A. Daley,Dieu-Trang Fuchs,Michael Pham,Keith L. Black,Altan Rentsendorj,Maya Koronyo-Hamaoui +12 more
TL;DR: Increased cerebral infiltration of monocytes, either by enrichment of their levels in the circulation or by weekly immunization with glatiramer acetate, resulted in substantial attenuation of disease progression in murine Alzheimer's models by mechanisms that involved enhanced cellular uptake and enzymatic degradation of toxic amyloid-β as well as regulation of brain inflammation.
Journal ArticleDOI
Antibody-Mediated Phagocytosis of the Amyloid β-Peptide in Microglia Is Differentially Modulated by C1q
Scott D. Webster,Manuel D. Galvan,Erick Ferran,William Garzon-Rodriguez,Charles G. Glabe,Andrea J. Tenner +5 more
TL;DR: FcR-dependent ingestion of Aβ-anti-Aβ complexes (IgG-fAβ) by microglia is demonstrated that is a function of the amount of Ab used to form immune complexes, and this may be beneficial in paradigms that seek to clear amyloid via F cR-mediated mechanisms by minimizing the potential for destructive Ab-induced complement-mediated processes.
Journal ArticleDOI
Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists.
TL;DR: The results identify two classes of receptors that cooperatively regulate the internalization of Abeta1-42 and support the hypothesis that characteristic pathologies of Alzheimer's disease occur once critical intraneuronal Abeta concentrations are reached.
Journal ArticleDOI
1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients
Mathew T Mizwicki,Guanghao Liu,Milan Fiala,Larry Magpantay,James Sayre,Avi Siani,Michelle Mahanian,Rachel Weitzman,Eric Y. Hayden,Mark J. Rosenthal,Ilka Nemere,John M. Ringman,David B. Teplow +12 more
TL;DR: In vitro, 1,25D3 and RvD1 rebalance inflammation to promote Aβ phagocytosis, and it is suggested that low vitamin D3 and docosahexaenoic acid intake and/or poor anabolic production of 1, 25D3/Rv D1 in PBMCs could contribute to AD onset/pathology.
Journal ArticleDOI
Nuclear receptors as therapeutic targets for Alzheimer's disease
TL;DR: It is the view that PPAR-γ activation remains a promising avenue for the treatment for AD; however, the poor BBB permeability of the currently available agonists and the negative outcome of the Phase III clinical trials are likely to diminish interest in pursuing this target.
References
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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