Inflammatory bowel disease pathogenesis: Where are we?
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TLDR
An “IBD integrome” approach that takes advantage of all functional information derived from the detailed investigation of each single pathogenic component through the use of systems biology may offer the solution to understand IBD and cure it.Abstract:
Inflammatory bowel disease (IBD) is presently one of the most investigated human disorders. Expansion of knowledge of its pathophysiology has helped in developing novel medications to combat gut inflammation with a considerably degree of success. Despite this progress, much more remains to be done in regard to gaining a more profound understanding of IBD pathogenesis, detecting inflammation before it clinically manifests, implementing lifestyle modifications, and developing agents that can modify the natural course of the disease. One of the limitations to achieve these goals is the lack of integration of the major components of IBD pathogenesis, that is the exposome, the genome, the gut microbiome, and the immunome. An “IBD integrome” approach that takes advantage of all functional information derived from the detailed investigation of each single pathogenic component through the use of systems biology may offer the solution to understand IBD and cure it.read more
Citations
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Advances in nutritional therapy in inflammatory bowel diseases: Review.
TL;DR: The role of nutrition in the etiopathogenesis of inflammatory bowel diseases (IBD) is discussed in this article, where the authors present the actual data from research studies on the influence of nutrition on IBD and the latest findings regarding its mechanisms of action.
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Clinical Pharmacokinetics and Pharmacodynamics of Infliximab in the Treatment of Inflammatory Bowel Disease.
TL;DR: A comprehensive review of the clinical pharmacokinetics and pharmacodynamics of infliximab, as well as the role of therapeutic drug monitoring in the treatment of IBD, is provided.
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The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review
Amber L. MacLellan,Jessica Connors,Jessica Connors,Shannan Grant,Leah E. Cahill,Morgan G. I. Langille,Johan Van Limbergen,Johan Van Limbergen +7 more
TL;DR: Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission.
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Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art
TL;DR: A bird’s eye view account on the success of liposome-based therapeutic systems in the management of dreadful inflammatory disorders along with updated knowledge to pharmaceutical scientists in the field is provided.
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Extraintestinal Manifestations of Inflammatory Bowel Disease: Epidemiology, Etiopathogenesis, and Management.
Ari Garber,Miguel Regueiro +1 more
TL;DR: EIMs are an increasingly recognized complication of IBD that require prompt recognition, multidisciplinary management, and a multifaceted therapeutic approach and this review highlights the complexities and ramifications of EIM management and offers therapeutic guidance.
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TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.